Results 71 to 80 of about 640,835 (387)

Chronic, Battery‐Free, Fully Implantable Multimodal Spinal Cord Stimulator for Pain Modulation in Small Animal Models

Advanced Science, EarlyView.
This work introduces wireless‐powered fully implantable spinal cord stimulation (SCS) in freely moving animal models, supporting diverse ethological paradigms. kHz stimulation with real‐time digital programming offers versatile, dynamically optimized therapy. Scalable fabrication ensures high N studies and seamless translation.
Allie J. Widman, Taron Bashar, Alex Burton, David Marshall Clausen, Prashant Gupta, Drew K. Wolf, Jakayla Folarin‐Hines, Maria Payne, John A Rogers, Kathleen W. Meacham, Robert W. Gereau, Philipp Gutruf   +11 more
wiley   +1 more source

Frailty Status, Not Just Age, is Associated With Postoperative Opioid Consumption: A Retrospective, Population-based Analysis

Annals of Surgery Open
Objective:. To assess the relationship between postoperative opioid consumption and frailty status. Background:. Physiologic reserve can be assessed through both chronologic age as well as measures of frailty.
Kyle R. Latack, MD, Ryan Howard, MD, Mark C. Bicket, MD, PhD, Samantha Cooley, MSW, Vidhya Gunaseelan, MBA, MS, MHA, Michael Englesbe, MD, Jennifer Waljee, MD, MPH, MS   +6 more
doaj   +1 more source

Cellular Tolerance Induced by Chronic Opioids in the Central Nervous System

Frontiers in Systems Neuroscience, 2022
Opioids are powerful analgesics that elicit acute antinociceptive effects through their action the mu opioid receptor (MOR). However opioids are ineffective for chronic pain management, in part because continuous activation of MORs induces adaptive ...
Sweta Adhikary, John T. Williams
doaj   +1 more source

Opioid Abuse in Chronic Pain--Misconceptions and Mitigation Strategies.

New England Journal of Medicine, 2016
Chronic pain not caused by cancer is among the most prevalent and debilitating medical conditions but also among the most controversial and complex to manage.
Dan L. Longo, N. Volkow, A. Mclellan
semanticscholar   +1 more source

Discrepancies in Written Versus Calculated Durations in Opioid Prescriptions: Pre-Post Study. [PDF]

, 2020
BACKGROUND: The United States is in the midst of an opioid epidemic. Long-term use of opioid medications is associated with an increased risk of dependence. The US Centers for Disease Control and Prevention makes specific recommendations regarding opioid
Babula, Bracken, Girondo, Melanie, Kairys, John, Martino, Cara, Riggio, Jeffrey, Roke, Lindsey M., Slovis, Benjamin H.   +6 more
core   +1 more source

Opioid Analgesic Prescribing Practices of Dental Professionals in the United States [PDF]

, 2017
The prescription of opioid analgesics by dental professionals is widespread in the United States. Policy makers, government agencies, and professional organizations consider this phenomenon a growing public health concern.
Okunseri, Christopher, Okunseri, Elaye, Steinmetz, C. N., Szabo, Aniko, Zheng, C.   +4 more
core   +2 more sources

The Lung Microbiome Modulates Pain‐Like Behavior Via the Lung–Brain Axis in a Nitroglycerin‐Induced Chronic Migraine Mouse Model

Advanced Science, EarlyView.
Intratracheal neomycin alters pulmonary microbiota, activating the vagus nerve via lung brain‐derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) pathway, further projecting to nucleus of solitary tract (NTS), then dorsal raphe nucleus (DRN), where activated serotoninergic neurons increase brain serotonin, alleviating migraine.
Biying Liu, Chengya Huang, Xin Li, Haonan Yu, Yuefeng Xia, Kun Liu, Xingji You, Jingxiang Wu   +7 more
wiley   +1 more source

Developing a comprehensive inventory to define harm reduction housing

Harm Reduction Journal
Background The City of Boston has faced unprecedented challenges with substance use amidst changes to the illicit drug supply and increased visibility of homelessness.
Sofia Zaragoza, Joseph Silcox, Sabrina Rapisarda, Charlie Summers, Patricia Case, Clara To, Avik Chatterjee, Alexander Y. Walley, Miriam Komaromy, Traci C Green   +9 more
doaj   +1 more source

Incidence of and Risk Factors for Chronic Opioid Use Among Opioid-Naive Patients in the Postoperative Period.

JAMA Internal Medicine, 2016
IMPORTANCE Chronic opioid use imposes a substantial burden in terms of morbidity and economic costs. Whether opioid-naive patients undergoing surgery are at increased risk for chronic opioid use is unknown, as are the potential risk factors for chronic ...
E. Sun, B. Darnall, L. Baker, S. Mackey
semanticscholar   +1 more source

When Epidemics Collide: Coronavirus Disease 2019 (COVID-19) and the Opioid Crisis

Annals of Internal Medicine, 2020
COVID-19 could cause infection in persons with opioid use disorder, increase opioid overdose rates, reverse system-level gains in expanding access to medication for opioid use disorder, halt critical research, and prevent exacting legal reparations ...
W. Becker, D. Fiellin
semanticscholar   +1 more source