Results 81 to 90 of about 640,835 (387)

State-Level Economic Costs of Opioid Use Disorder and Fatal Opioid Overdose — United States, 2017

MMWR. Morbidity and mortality weekly report, 2021
Approximately 47,000 persons in the United States died from an opioid-involved overdose in 2018 (1), and 2.0 million persons met the diagnostic criteria for an opioid use disorder in 2017 (2). The economic cost of the U.S.
Feijun Luo, Mengyao Li, C. Florence
semanticscholar   +1 more source

How the presentation of patient information and decision-support advisories influences opioid prescribing behavior: A simulation study [PDF]

, 2020
ObjectiveThe United States faces an opioid crisis. Integrating prescription drug monitoring programs into electronic health records offers promise to improve opioid prescribing practices.
Hussain, Mustafa I, Nelson, Ariana M, Sukumar, Lauren, Yeung, Brent G, Zheng, Kai   +4 more
core  

S‐ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide‐Induced Depression Via Targeting SIRT2

Advanced Science, EarlyView.
S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin, Xiaoxuan Zhou, Mingqi Li, Cong Zhang, Haojiang Zhai, Haohong Li, Hongshuang Wang, Xiaohui Wang   +7 more
wiley   +1 more source

Study assessing the effectiveness of overdose prevention centers through research (SAFER): an overview of the study protocol

Harm Reduction Journal
More than one million people have died from drug overdose in the United States in the past 20 years. The overdose crisis started in the late 1990s with the proliferation of overdoses involving prescription opioids, transitioned to heroin-involved ...
Cerdá Magdalena, L. Allen Bennett, B. Collins Alexandra, N. Behrends Czarina, Santacatterina Michele, Jent Victoria, D. L. Marshall Brandon   +6 more
doaj   +1 more source

Luaran Penggunaan Analgesik Opiat pada Pasien Kanker

Jurnal Manajemen dan Pelayanan Farmasi, 2019
Cancer pain might reduce the quality of life of cancer patients. Opioids are the drug of choice in cancer pain management. Fentanyl and other opioids are often prescribed.
Salma Fajar Puspita, Zullies Ikawati, Apt., Retno Muliawati   +2 more
doaj   +1 more source

Simultaneous brain, brainstem, and spinal cord pharmacological-fMRI reveals involvement of an endogenous opioid network in attentional analgesia

eLife, 2022
Pain perception is decreased by shifting attentional focus away from a threatening event. This attentional analgesia engages parallel descending control pathways from anterior cingulate (ACC) to locus coeruleus, and ACC to periaqueductal grey (PAG ...
Valeria Oliva, Ron Hartley-Davies, Rosalyn Moran, Anthony E Pickering, Jonathan CW Brooks   +4 more
doaj   +1 more source

Nitrous Oxide: Mechanism of Its Antinociceptive Action [PDF]

, 1995
Nitrous oxide (N2O) is an anesthetic gas known to produce an analgesic effect at sub-anesthetic concentrations. This analgesic property of N2O can be clinically exploited in a broad range of conditions where pain relief is indicated.
Quock, Raymond M., Vaughn, Linda K.
core   +1 more source

Locus Coeruleus Noradrenergic‐Spinal Projections Contribute to Electroacupuncture‐Mediated Antinociception in Postoperative Pain in Mice

Advanced Science, EarlyView.
How locus coeruleus noradrenergic‐spinal projections and subsequent α2A adrenoceptors‐CaMKII signaling cascades contribute to electroacupuncture‐induced antinociception in postoperative pain in mice is described. Abstract Postoperative pain remains a significant challenge in healthcare.
Wen‐Guang Chu, Ru Zhang, Hai‐Tao Li, Ying‐Chun Li, Hui Ding, Zhen‐Zhen Li, Wen‐Juan Han, Fei Wang, Xing‐Xing Zheng, Hong‐Hui Mao, Hua Yuan, Sheng‐Xi Wu, Rou‐Gang Xie, Ceng Luo   +13 more
wiley   +1 more source

Hyperpolarization Modulation of the T‐Type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects

Angewandte Chemie, EarlyView.
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka, Yusuke Yano, Nozomi Hara, Chihiro Sadamoto, Andres D. Maturana, Masaki Kita   +5 more
wiley   +2 more sources

A Call for Better Opioid Prescribing Training and Education

Western Journal of Emergency Medicine, 2016
Pain is the most common complaint in the emergency department (ED), and emergency physicians face unique challenges in making opioid-related treatment decisions.
Hazar Khidir, Scott G. Weiner
doaj   +1 more source