Results 91 to 100 of about 2,872,365 (306)

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

Systemic administration of a delta opioid receptor agonist, KNT-127, facilitates extinction learning of fear memory in rats

Journal of Pharmacological Sciences, 2019
Strategies to facilitate extinction of fear memory have attracted increasing attention for enhancing the effectiveness of exposure therapy for anxiety disorders. Previously, we demonstrated that systemic administration of a delta opioid receptor agonist,
Azusa Sugiyama, Misa Yamada, Hiroki Furuie, Leo Gotoh, Akiyoshi Saitoh, Hiroshi Nagase, Jun-Ichiro Oka, Mitsuhiko Yamada   +7 more
doaj   +1 more source

Kappa Opioid Regulation of Stress-Related Behavior [PDF]

, 2010
Anxiety disorders affect roughly 40 million American adults in a given year. Those suffering from anxiety disorders often experience additional stress-linked illnesses, such as depression.
Harshberger, Erin
core  

Cannabis use and opioid relapse: An exploratory survival analysis of prospectively collected data

Frontiers in Psychiatry, 2022
ImportanceIt is known that only minority of patients with opioid use disorder (OUD) receive treatment, of which only a fraction successfully complete treatment as intended.
Leen Naji, Leen Naji, Tea Rosic, Tea Rosic, Nitika Sanger, Brittany Dennis, Alannah Hillmer, Jacqueline Hudson, Andrew Worster, Andrew Worster, James Paul, David C. Marsh, Lehana Thabane, Lehana Thabane, Zainab Samaan, Zainab Samaan   +15 more
doaj   +1 more source

sj-png-1-cpa-10.1177_07067437231194385 - Supplemental material for The Association Between Self-Reported Anxiety and Retention in Opioid Agonist Therapy: Findings From a Canadian Pragmatic Trial

, 2023
Supplemental material, sj-png-1-cpa-10.1177_07067437231194385 for The Association Between Self-Reported Anxiety and Retention in Opioid Agonist Therapy: Findings From a Canadian Pragmatic Trial by Anees Bahji, Gabriel Bastien, Paxton Bach, JinCheol Choi,
Paxton Bach (14767121), Gabriel Bastien (13928931), Ron Lim (14267577), Didier Jutras-Aswad (318243), Bernard Le Foll (68408), JinCheol Choi (11268357), M. Eugenia Socias (14267574), Anees Bahji (7438085)   +7 more
core   +1 more source

Low-dose Initiation of Buprenorphine/naloxone for the Management of Chronic Non-cancer Pain in Patients on Long-term Opioid Therapy: A Case Series

Canadian Journal of Pain
Background Buprenorphine may provide superior analgesia to full opioid agonist therapy and reverse the effects of opioid-induced hyperalgesia, while having a favorable safety profile and fewer adverse effects, in chronic non-cancer pain treatment.
Maya Rattanavong, Donica Kwan, Derek Jorgenson, Eric Landry, Radhika Marwah, Katelyn Halpape   +5 more
doaj   +1 more source

Health-related quality of life of long-term patients receiving opioid agonist therapy: a nested prospective cohort study in Norway

Substance Abuse Treatment, Prevention, and Policy, 2020
Background Opioid dependence carries the highest disease burden of all illicit drugs. Opioid agonist therapy (OAT) is an evidence-based medical intervention that reduces morbidity and mortality. There is limited knowledge on the health-related quality of
C. Aas, J. Vold, S. Skurtveit, A. Lim, S. Ruths, K. Islam, J. Askildsen, E. Løberg, L. Fadnes, K. Johansson   +9 more
semanticscholar   +1 more source

Paediatric clonidine medication errors: Findings from a multicentre French study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to describe the characteristics of medication errors involving clonidine in paediatric patients and reported to French Network of Pharmacovigilance and Poison Control Centres. Methods This retrospective observational study analysed clonidine‐related medication errors reported between 1985 and June 2024 in patients under 12 years ...
Eve‐Marie Thillard, Anthony Facile, Marion Lepelley, Morgane Cellier, Laurent Chouchana, Sophie Gautier, Ramy Azzouz, Thierry Vial, Annie‐Pierre Jonville‐Bera   +8 more
wiley   +1 more source

Buprenorphine is a weak dopamine releaser relative to heroin, but its pretreatment attenuates heroin‐evoked dopamine release in rats

Neuropsychopharmacology Reports, 2020
Aims The United States of America is currently in an opioid epidemic. Heroin remains the most lethal opioid option with its death rate increasing by over 500% in the last decade.
Dominic P. Isaacs, Ryan P. Leman, Thomas J. Everett, Hendrick Lopez‐Beltran, Lindsey R. Hamilton, Erik B. Oleson   +5 more
doaj   +1 more source

Changes and trends in medication-assisted treatment in Israel

Israel Journal of Health Policy Research, 2023
Background As opioid prescription in Israel is increasing, there is a growing need for monitoring opioid use disorder and providing opioid agonist therapy.
Adi Marom, Iris Levy, Paola Rosca
doaj   +1 more source