Results 81 to 90 of about 2,872,365 (306)

Evaluating the feasibility of prolonged-release buprenorphine formulations as an alternative to daily opioid agonist therapy regardless of prior treatment adherence: a pilot study

Pilot and Feasibility Studies, 2023
Background Effective opioid agonist therapy (OAT) depends on good patient adherence. However, the daily, supervised administration of standard OAT represents a significant burden to patients and often drives poor adherence.
Bernadette Hard, Mohan DeSilva
doaj   +1 more source

Opioid Agonist Therapy: Medication Barriers and Predicting Successful Retention

, 2023
Canada is currently experiencing an opioid crisis of an unprecedented magnitude. Opioid agonist therapy (OAT) medications are the first-line intervention for opioid use disorder.

core  

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

Advanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen, Jianhua Lv, Yuanqing Cai, Xuhui Yuan, Hongxin Hu, Jiayu Li, Yiming Lin, Hongyan Li, Lan Lin, Huangfeng Lin, Chaofan Zhang, Qijin Wang, Ying Huang, Zida Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Xinyu Fang, Wenming Zhang   +19 more
wiley   +1 more source

Factors that impact opioid agonist therapy in Northern and Rural Ontario [PDF]

, 2016
Opioid agonist therapy is the gold standard of care for opioid dependence. However, the efficacy of treatment may be hindered by concurrent drug use, including cocaine and benzodiazepines.
Franklyn, Alexandra Michelle
core   +1 more source

Rationale, design, and methodology of a trial evaluating three models of care for HCV treatment among injection drug users on opioid agonist therapy

BMC Infectious Diseases, 2018
Background People who inject drugs (PWID) constitute 60% of the approximately 5 million people in the U.S. infected with hepatitis C virus (HCV). Treatment of PWID is complex due to addiction, mental illness, poverty, homelessness, lack of positive ...
Matthew J. Akiyama, Linda Agyemang, Julia H. Arnsten, Moonseong Heo, Brianna L. Norton, Bruce R. Schackman, Benjamin P. Linas, Alain H. Litwin   +7 more
doaj   +1 more source

The opioid crisis in North America: facts and future lessons for Europe

Anaesthesiology Intensive Therapy, 2020
Over the past two decades, opioid-related hospitalizations and deaths in North America have reached the level of a public health emergency. Initially, the epidemic of opioid misuse was largely driven by pharmaceutical companies and initiated by their ...
Kennedy Ayoo, John Mikhaeil, Alexander Huang, Marcin Wąsowicz   +3 more
doaj   +1 more source

Facilitators of initiating opioid agonist treatments reported by physicians working in provincial correctional facilities for adults in Ontario, Canada, % of N = 27.

, 2018
*OST = opioid substitution therapy, which includes opioid agonist treatments methadone and buprenorphine/naloxone.
Alexandra Patel (4856797), Lori Kiefer (3157992), Matthew J. To (504576), Leonora Regenstreif (4856794), Fiona G. Kouyoumdjian (489495)   +4 more
core   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

Barriers to initiating opioid agonist treatments reported by physicians working in provincial correctional facilities for adults in Ontario, Canada, % of N = 27.

, 2018
*OST = opioid substitution therapy, which includes opioid agonist treatments methadone and buprenorphine/naloxone.
Alexandra Patel (4856797), Lori Kiefer (3157992), Matthew J. To (504576), Leonora Regenstreif (4856794), Fiona G. Kouyoumdjian (489495)   +4 more
core   +1 more source

Innovative Approach Reveals How Receptors Control G Protein State Equilibria

Advanced Science, EarlyView.
Using conformational specific trFRET biosensors of the Gi protein (depicted at the bottom), the authors show that receptor activation can not only release GDP from the inactive G protein, but can also release GTP from the activated G protein, leading to the reformation of the RG ternary complex.
Alexandre Bouyssou, Mélanie Da Silva, Julien Soulé, Ludovic Fabre, Laurent Lamarque, Rémy Sounier, Thierry Durroux, Sébastien Granier, Thomas Roux, Elodie Dupuis, Eric Trinquet, Philippe Rondard, Jean‐Philippe Pin   +12 more
wiley   +1 more source