Results 61 to 70 of about 22,201 (271)

Rationale, design, and methodology of a trial evaluating three models of care for HCV treatment among injection drug users on opioid agonist therapy

BMC Infectious Diseases, 2018
Background People who inject drugs (PWID) constitute 60% of the approximately 5 million people in the U.S. infected with hepatitis C virus (HCV). Treatment of PWID is complex due to addiction, mental illness, poverty, homelessness, lack of positive ...
Matthew J. Akiyama, Linda Agyemang, Julia H. Arnsten, Moonseong Heo, Brianna L. Norton, Bruce R. Schackman, Benjamin P. Linas, Alain H. Litwin   +7 more
doaj   +1 more source

The opioid crisis in North America: facts and future lessons for Europe

Anaesthesiology Intensive Therapy, 2020
Over the past two decades, opioid-related hospitalizations and deaths in North America have reached the level of a public health emergency. Initially, the epidemic of opioid misuse was largely driven by pharmaceutical companies and initiated by their ...
Kennedy Ayoo, John Mikhaeil, Alexander Huang, Marcin Wąsowicz   +3 more
doaj   +1 more source

Assessment of Abuse Potential‐Related Effects of Oral Dried Kratom Leaf Powder in Healthy Normal Participants Following Single and Multiple Daily Doses

Drug Testing and Analysis, EarlyView.
In a randomized, double‐blind, placebo‐controlled study of oral dried kratom leaf powder in healthy kratom‐naive adults, no participants met the clinically meaningful opioid withdrawal threshold; abuse‐related treatment‐emergent adverse events occurred more frequently at higher doses but were generally mild and resolved without sequelae; and no serious
Marion Coe, Marilyn Huestis, Daniel Wang, Thomas Hudzik, John Bothmer, Jack Henningfield   +5 more
wiley   +1 more source

Opioid Agonist Therapy: Medication Barriers and Predicting Successful Retention

, 2023
Canada is currently experiencing an opioid crisis of an unprecedented magnitude. Opioid agonist therapy (OAT) medications are the first-line intervention for opioid use disorder.

core  

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, EarlyView.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source

Comportamento de coçar e nocicepção evidenciados após a aplicação facial de endotelina-1: um novo teste, uma nova oportunidade farmacológica [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2011O presente trabalho reproduziu o modelo experimental descrito por Shimada e Lamotte, (2008), e o
Gomes, Lenyta Oliveira
core  

Fatalities within seven days after equine standing sedation: A prospective, multicentre study

Equine Veterinary Journal, EarlyView.
Abstract Background Information regarding mortality associated with standing procedures in horses is sparse. Objectives To report data from >12,000 standing sedations. Study Design Confidential, observational, prospective, multicentre, cohort study.
Miguel Gozalo‐Marcilla, José I. Redondo, Polly M. Taylor, Luis Domenech, Javier Doménech, Gordon Mark Johnston, Regula Bettschart‐Wolfensberger   +6 more
wiley   +1 more source

Systemic administration of a delta opioid receptor agonist, KNT-127, facilitates extinction learning of fear memory in rats

Journal of Pharmacological Sciences, 2019
Strategies to facilitate extinction of fear memory have attracted increasing attention for enhancing the effectiveness of exposure therapy for anxiety disorders. Previously, we demonstrated that systemic administration of a delta opioid receptor agonist,
Azusa Sugiyama, Misa Yamada, Hiroki Furuie, Leo Gotoh, Akiyoshi Saitoh, Hiroshi Nagase, Jun-Ichiro Oka, Mitsuhiko Yamada   +7 more
doaj   +1 more source

Providing Mental Health and Substance Use Services to People Released From Custody During the COVID‐19 Pandemic: A Qualitative Study of Service Providers

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT This paper explores the perspectives of mental health and substance use providers who supported people released from custody during the pandemic in Ontario, Canada, with a focus on service disruptions, adaptations, and experiences. We conducted 20 in‐depth qualitative interviews and analysed these using Applied Thematic Analysis.
Lucas M. Seuren, Arthur McLuhan, Madison Ford, Nikoleta Curcin, Angela Mashford‐Pringle, Patricia O'Campo, Flora I. Matheson   +6 more
wiley   +1 more source

Cannabis use and opioid relapse: An exploratory survival analysis of prospectively collected data

Frontiers in Psychiatry, 2022
ImportanceIt is known that only minority of patients with opioid use disorder (OUD) receive treatment, of which only a fraction successfully complete treatment as intended.
Leen Naji, Leen Naji, Tea Rosic, Tea Rosic, Nitika Sanger, Brittany Dennis, Alannah Hillmer, Jacqueline Hudson, Andrew Worster, Andrew Worster, James Paul, David C. Marsh, Lehana Thabane, Lehana Thabane, Zainab Samaan, Zainab Samaan   +15 more
doaj   +1 more source