Results 71 to 80 of about 2,872,365 (306)

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Logistic regression estimates for receipt of opioid agonist therapy for opioid use disorder among admitted patients, 2014–17.

, 2019
Logistic regression estimates for receipt of opioid agonist therapy for opioid use disorder among admitted patients, 2014–17.
Justin C. Yang (6882941), Carol Brayne (17434), Andres Roman-Urrestarazu (5447288)   +2 more
core   +1 more source

Characteristics of admitted patients either receiving or not receiving opioid agonist therapy for opioid use disorder, 2014–17.

, 2019
Characteristics of admitted patients either receiving or not receiving opioid agonist therapy for opioid use disorder, 2014–17.
Justin C. Yang (6882941), Carol Brayne (17434), Andres Roman-Urrestarazu (5447288)   +2 more
core   +1 more source

The journey of opioid substitution therapy in India: Achievements and challenges

Indian Journal of Psychiatry, 2017
Opioids are one of the most problematic illegal substances globally. Opioid abuse is associated with complications in various spheres of the user's life, his/her family, and the society.
Ravindra Rao
doaj   +1 more source

Association between opioid agonist therapy and testing, treatment uptake, and treatment outcomes for hepatitis C infection among people who inject drugs: A systematic review and meta-analysis.

Clinical Infectious Diseases, 2020
BACKGROUND People who inject drugs (PWID) experience barriers to accessing testing and treatment for hepatitis C virus (HCV) infection. Opioid agonist therapy (OAT) may provide an opportunity to improve access to HCV care. This systematic review assessed
J. Grebely, L. Tran, L. Degenhardt, Alexander Dowell-Day, Thomas Santo, S. Larney, M. Hickman, P. Vickerman, C. French, Kerryn Butler, Daisy M. Gibbs, H. Valerio, P. Read, G. Dore, B. Hajarizadeh   +14 more
semanticscholar   +1 more source

Mal/adaptations: A qualitative evidence synthesis of opioid agonist therapy during major disruptions [PDF]

, 2022
Opioid agonist therapy (OAT) has been severely disrupted by the COVID-19 pandemic. The risks of opioid withdrawal, overdose, and diversion have increased, so there is an urgent need to adapt OAT to best support people who use drugs (PWUD).
Sabioni, Pamela, Cheng, Darren K., Salamanca-Buentello, Fabio, Majid, Umair, Upshur, Ross, Sud, Abhimanyu, Pamela Sabioni, Ross Upshur, Fabio Salamanca-Buentello, Darren K. Cheng, Umair Majid, Abhimanyu Sud   +11 more
core   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

Evaluating comparative effectiveness of psychosocial interventions adjunctive to opioid agonist therapy for opioid use disorder: A systematic review with network meta-analyses

PLoS ONE, 2020
Background Guidelines recommend that individuals with opioid use disorder (OUD) receive pharmacological and psychosocial interventions; however, the most appropriate psychosocial intervention is not known.
D. Rice, K. Corace, D. Wolfe, L. Esmaeilisaraji, Alan Michaud, Alicia A Grima, Bradley Austin, R. Douma, P. Barbeau, C. Butler, M. Willows, P. Poulin, B. Sproule, A. Porath, G. Garber, Sheena Taha, Gord Garner, B. Skidmore, D. Moher, K. Thavorn, B. Hutton   +20 more
semanticscholar   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source