Results 51 to 60 of about 22,201 (271)

Confounding of the Comparative Safety of Prenatal Opioid Agonist Therapy

Journal of Addiction Research & Therapy, 2015
Prenatal opioid agonist therapy with methadone or buprenorphine prevents maternal illicit opioid use and withdrawal and improves pregnancy outcomes compared to heroin use alone. Historically, methadone has been the first-line opioid agonist therapy for pregnant opioid dependent women; in recent years buprenorphine has become first-line treatment for ...
Susan B, Brogly, Kristen A, Hahn, Sonia Hernandez, Diaz, Martha, Werler   +3 more
openaire   +2 more sources

Suicide in people prescribed opioid-agonist therapy in Scotland, United Kingdom, 2011-2020: A national retrospective cohort study. [PDF]

Addiction
BACKGROUND AND AIMS Opioid dependence is associated with an increased risk of suicide. Drug-related mortality among people with opioid dependence in Scotland has more than tripled since 2010; less is known about changes in suicide risk.
Fraser R, Yeung A, Glancy M, Hickman M, Jones HE, Priyadarshi S, Horsburgh K, Hutchinson SJ, McAuley A.   +8 more
europepmc   +3 more sources

The journey of opioid substitution therapy in India: Achievements and challenges

Indian Journal of Psychiatry, 2017
Opioids are one of the most problematic illegal substances globally. Opioid abuse is associated with complications in various spheres of the user's life, his/her family, and the society.
Ravindra Rao
doaj   +1 more source

Impact of the Russian invasion on opioid agonist therapy programs in Ukraine: A qualitative study. [PDF]

Drug Alcohol Depend
BACKGROUND: Opioid Agonist Treatment (OAT) combines opioid agonist medications with counseling and therapy for a whole-patient approach to treating opioid use disorder.
Dubov A, Basenko A, Dymaretskyi O, Shoptaw S.   +3 more
europepmc   +2 more sources

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Characteristics of admitted patients either receiving or not receiving opioid agonist therapy for opioid use disorder, 2014–17.

, 2019
Characteristics of admitted patients either receiving or not receiving opioid agonist therapy for opioid use disorder, 2014–17.
Justin C. Yang (6882941), Carol Brayne (17434), Andres Roman-Urrestarazu (5447288)   +2 more
core   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Evaluating the feasibility of prolonged-release buprenorphine formulations as an alternative to daily opioid agonist therapy regardless of prior treatment adherence: a pilot study

Pilot and Feasibility Studies, 2023
Background Effective opioid agonist therapy (OAT) depends on good patient adherence. However, the daily, supervised administration of standard OAT represents a significant burden to patients and often drives poor adherence.
Bernadette Hard, Mohan DeSilva
doaj   +1 more source

Logistic regression estimates for receipt of opioid agonist therapy for opioid use disorder among admitted patients, 2014–17.

, 2019
Logistic regression estimates for receipt of opioid agonist therapy for opioid use disorder among admitted patients, 2014–17.
Justin C. Yang (6882941), Carol Brayne (17434), Andres Roman-Urrestarazu (5447288)   +2 more
core   +1 more source

GLP‐1 Receptor Agonists and Endoscopy: Understanding Gastric Stasis, Aspiration Risk, and Contemporary Peri‐Procedural Guidance

Chronic Diseases and Translational Medicine, EarlyView.
Pharmacological mechanisms and physiologic effects of GLP‐1 receptor agonists relevant to peri‐endoscopic risk. ABSTRACT The global increase in obesity, type 2 diabetes mellitus (T2DM), and metabolic dysfunction‐associated steatotic liver disease (MASLD) has led to a higher use of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) among patients ...
Junaid Beig, Jason Ta, Sophie Jones, Emily Scott, Khalid Sofi, Frances Osler, Marije Jansen, Puneet Chhabra   +7 more
wiley   +1 more source