Results 161 to 170 of about 7,007,196 (291)

Real‐World Evidence for Existing Anti‐Obesity Therapies—The Realities of Treatment Adherence, Tolerability, Access and Patient Satisfaction

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Obesity is associated with substantial cardiometabolic and psychosocial morbidity. Although randomized controlled trials demonstrate the efficacy of anti‐obesity therapies, outcomes in real‐world practice may be attenuated due to limited access, tolerability, adherence and insufficient long‐term support.
Sameer Kassem
wiley   +1 more source

Community Pharmacy-Based Injectable Opioid Agonist Treatment: Findings From a Canadian Pilot Program. [PDF]

Drug Alcohol Rev
Mihic T, Socias ME, McCrae K, Johnson C, Nolan S, Grant C, Sutherland C, Fairbairn N.   +7 more
europepmc   +1 more source

Methylnaltrexone in the treatment of opioid-induced constipation

, 2008
Beverley Greenwood-Van Meerveld1, Kelly M Standifer21Veterans Affairs Medical Center, Oklahoma Center for Neuroscience, Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; 2Department of Pharmaceutical ...
Beverley Greenwood-Van Meerveld, Kelly M Standifer   +1 more
core  

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Factors associated with changes in opioid analgesic prescribing after opioid agonist treatment initiation: A nationwide registry cohort study. [PDF]

Drug Alcohol Depend Rep
Rolova G, Skurtveit S, Bukten A, Odsbu I, Eide D.   +4 more
europepmc   +1 more source

Contributions of Positive Social Interactions to Vocal Learning and Social Cohesion

Ethology, EarlyView.
Birdsong produced in non‐breeding flocks is shaped by a dynamic interplay between intrinsic reward and social feedback. Studies in cowbirds and starlings suggest that positive affective states and opioid‐mediated reward promote song practice, while responses from flock mates, potentially reinforced by dopaminergic mechanisms, refine species‐typical ...
Lauren V. Riters, Alyse N. Maksimoski
wiley   +1 more source

Acceptability of Self-Help Plus and Problem Management Plus interventions among clients and implementation insights from staff of Opioid Agonist Treatment programs in Ukraine. [PDF]

PLOS Ment Health
Klymchuk V, Gorbunova V, Romanchuk V, Ivanchuk I.   +3 more
europepmc   +1 more source

Anaesthetic management of a horse with acute kidney injury

Equine Veterinary Education, EarlyView.
Summary Anaesthetic management of animals with acute kidney injuries (AKI) is complex and poses considerable risk. There are no publications describing management of anaesthetised horses with AKI. Perioperative and anaesthetic care of a Thoroughbred filly presented with traumatic injuries and subsequent AKI is described.
C. T. Quinn, K. J. Hughes, A. N. Walton
wiley   +1 more source

Not all costs are the same: understanding costs of opioid agonist treatment around the world. [PDF]

AIDS
Behrends CN, Schackman BR.
europepmc   +1 more source

Ovarian pain in the mare: Clinical implications of mittelschmerz and oestrus‐related behavioural abnormalities

Equine Veterinary Education, EarlyView.
Summary Mittelschmerz is a well‐recognised benign peri‐ovulatory pain syndrome in women and, by physiological analogy, may also occur in mares. In equine practice, peri‐ovulatory ovarian pain has been associated with transient discomfort, colic‐like signs and behavioural changes, although its true clinical relevance remains poorly defined.
G. Marino, V. Biondi, A. Sfacteria, G. Catone, C. Vullo   +4 more
wiley   +1 more source