Results 1 to 10 of about 424,484 (215)
Pain, Opioid Analgesics, and Cognition: A Conceptual Framework in Older Adults. [PDF]
Pain Med, 2023 Chronic pain is highly prevalent in older adults and is associated with poor functional outcomes. Further, opioid analgesics are commonly utilized for the treatment of pain in older adults despite well-described adverse effects. Importantly, both chronic
Warner NS +6 more
europepmc +2 more sources
Structure-based discovery of opioid analgesics with reduced side effects
Nature, 2016 Aashish Manglik +2 more
exaly +2 more sources
Clinical practice guideline for deprescribing opioid analgesics: summary of recommendations
Medical Journal of Australia, 2023 Long term opioids are commonly prescribed to manage pain. Dose reduction or discontinuation (deprescribing) can be challenging, even when the potential harms of continuation outweigh the perceived benefits.
A. Langford +16 more
semanticscholar +1 more source
Opioid analgesics for nociceptive cancer pain: A comprehensive review
Ca, 2023 Pain is one of the most burdensome symptoms in people with cancer, and opioid analgesics are considered the mainstay of cancer pain management. For this review, the authors evaluated the efficacy and toxicities of opioid analgesics compared with placebo,
Christina Abdel Shaheed +8 more
semanticscholar +1 more source
JAMA Network Open, 2021 Key Points Question How has prescribing of opioid analgesics and buprenorphine for opioid use disorder changed throughout the COVID-19 pandemic? Findings This cross-sectional study analyzed prescriptions from 90 420 353 patients and found that from March
J. Currie +3 more
semanticscholar +1 more source
Strategies towards safer opioid analgesics—A review of old and upcoming targets
British Journal of Pharmacology, 2021 Opioids continue to be of use for the treatment of pain. Most clinically used analgesics target the μ opioid receptor whose activation results in adverse effects like respiratory depression, addiction and abuse liability.
Balazs R. Varga +2 more
semanticscholar +1 more source
Prenatal Opioid Analgesics and the Risk of Adverse Birth Outcomes
Epidemiology, 2021 Supplemental Digital Content is available in the text. Background: It is unclear whether confounding accounts for the increased risk of preterm birth and small for gestational age (SGA) birth in opioid analgesic exposed pregnancies.
Susan B. Brogly +5 more
semanticscholar +1 more source
BMC Public Health, 2021 Physicians do not prescribe opioid analgesics for pain treatment equally across groups, and such disparities may pose significant public health concerns. Although research suggests that institutional constraints and cultural stereotypes influence doctors’
L. Keister +5 more
semanticscholar +1 more source
Efficacy of non-opioid analgesics to control postoperative pain: a network meta-analysis
BMC Anesthesiology, 2020 Background The aim of this network meta-analysis (NMA) was to evaluate the safety and efficacy of intravenous (IV) Meloxicam 30 mg (MIV), an investigational non-steroidal anti-inflammatory drug (NSAID), and certain other IV non-opioid analgesics for ...
J. Carter +4 more
semanticscholar +1 more source
Non-opioid Analgesics and the Endocannabinoid System
Balkan Medical Journal, 2020 Non-steroidal anti-inflammatory drugs produce antinociceptive effects mainly through peripheral cyclooxygenase inhibition. In opposition to the classical non-steroidal anti-inflammatory drugs, paracetamol and dipyrone exert weak anti-inflammatory ...
R. Topuz +3 more
semanticscholar +1 more source