Results 1 to 10 of about 87,811 (348)
Opioid analgesics for chronic noncancer pain in patients prescribed opioid agonist therapy or with opioid use disorder: A systematic review [PDF]
Canadian Journal of PainBackground Opioid use disorder (OUD) is a growing public health concern in North America, often coexisting with chronic noncancer pain (CNCP). Managing both conditions presents unique challenges, highlighting the need for evidence to guide decision ...
Vahid Ashoorion +9 more
doaj +2 more sources
Prescribing databases can be used to monitor trends in opioid analgesic prescribing in Australia [PDF]
Australian and New Zealand Journal of Public Health, 2013 Objective: There has been increased use of prescription opioid analgesics in Australia in the past 20 years with increasing evidence of related problems. A number of data sources collect information about the dispensed prescribing for opioid medications,
Samantha A. Hollingworth +6 more
doaj +2 more sources
Opioid analgesics: Managing the predictable [PDF]
Clinical MedicineIt is imperative for clinicians to understand the common adverse effects of opioid therapy and ensure patients are properly counselled on them prior to opioid initiation. Predictable adverse effects are wide ranging, and include bowel dysfunction, nausea,
A Barnes +2 more
doaj +2 more sources
Opioid peptide-derived analgesics [PDF]
The AAPS Journal, 2005 Two recent developments of opioid peptide-based analgesics are reviewed. The first part of the review discusses the dermorphin-derived, cationic-aromatic tetrapeptide H-Dmt-D-Arg-Phe-Lys-NH(2) ([Dmt(1)]DALDA, where Dmt indicates 2',6'-dimethyltyrosine), which showed subnanomolar mu receptor binding affinity, extraordinary mu receptor selectivity, and ...
Peter W. Schiller
openaire +5 more sources
Health Promotion and Chronic Disease Prevention in Canada, 2021 IntroductionHarms caused by prescription opioid analgesics (POAs) have been identified as a major international public health concern. Recent statistics show rising numbers of opioid-related deaths across Canada.
Joshua Goodwin, Susan Kirkland
doaj +1 more source
Kidney Diseases, 2023 Introduction: Comprehensive data on the risk of hospital-acquired (HA) acute kidney injury (AKI) among adult users of opioid analgesics are lacking.
Mingjing Pi +27 more
doaj +1 more source
Adverse selection? A multi-dimensional profile of people dispensed opioid analgesics for persistent non-cancer pain. [PDF]
PLoS ONE, 2013 OBJECTIVES: This study investigates utilisation patterns for prescription opioid analgesics in the Australian community and how these are associated with a framework of individual-level factors related to healthcare use.
Kris D Rogers +3 more
doaj +1 more source
IUPHAR Review - Bivalent and bifunctional opioid receptor ligands as novel analgesics
Pharmacological Research, 2023 Though efficacious in managing chronic, severe pain, opioid analgesics are accompanied by significant adverse effects including constipation, tolerance, dependence, and respiratory depression.
Kyle J. Rehrauer +1 more
doaj +1 more source
Pharmaceutics, 2021 The use of opioid analgesics in treating severe pain is frequently associated with putative adverse effects in humans. Topical agents that are shown to have high efficacy with a favorable safety profile in clinical settings are great alternatives for ...
Maksim Khotimchenko +4 more
doaj +1 more source
BMC Health Services Research, 2020 Background Dispensations of opioid analgesics to patients on opioid agonist therapy (OAT) may increase the risk of overdoses. The current study’s objectives are to investigate the dispensation rates and mean daily doses of dispensed opioid analgesics ...
Jørn Henrik Vold +4 more
doaj +1 more source