Results 71 to 80 of about 57,069 (292)

Research progress on biased μ-opioid receptor agonists

open access: yes徐州医科大学学报
Opioid analgesics, which primarily exert their effects through μ-opioid receptors, have long been valuable choices in pain management. However, opioid analgesics often cause various adverse reactions that are common to traditional opioids, especially ...
LI Ning, LIU Cunming
doaj   +1 more source

Long-Term Medicare Costs Associated With Opioid Analgesic Therapy vs Spinal Manipulative Therapy for Chronic Low Back Pain in a Cohort of Older Adults

open access: green, 2021
James M. Whedon   +8 more
openalex   +2 more sources

Multimodal Pain Management in Older Elective Arthroplasty Patients

open access: yesGeriatric Orthopaedic Surgery & Rehabilitation, 2017
Background: Pain management after elective arthroplasty in older adults is complicated due to the risk of undertreatment of postoperative pain and potential adverse effects from analgesics, notably opioids.
Elaine Brooks MN   +3 more
doaj   +1 more source

Research progress on the depth of anesthesia monitoring based on the electroencephalogram

open access: yesIbrain, Volume 11, Issue 1, Page 32-43, Spring 2025.
Electroencephalogram (EEG) can noninvasive, continuous, and real‐time monitor the state of brain electrical activity, and the monitoring of EEG can reflect changes in the depth of anesthesia (DOA). The development of artificial intelligence can enable anesthesiologists to extract, analyze, and quantify DOA from complex EEG data.
Xiaolan He, Tingting Li, Xiao Wang
wiley   +1 more source

The changing landscape of opioid prescribing: long-acting and extended-release opioid class-wide Risk Evaluation and Mitigation Strategy

open access: yesTherapeutics and Clinical Risk Management, 2012
Jeffrey A GudinEnglewood Hospital and Medical Center, Englewood, NJ, USAAbstract: Prescriptions for opioid analgesics to manage moderate-to-severe chronic noncancer pain have increased markedly over the last decade, as have postmarketing reports of ...
Gudin JA
doaj  

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

open access: yesIbrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

The Influence of Gene Polymorphism OPRM1 118A/G on the Perception of Pain and Pharmacodynamics of Narcotic Analgesics

open access: yesОбщая реаниматология, 2014
The polymorphism of μ-opioid receptor is one of the most studied polymorphisms that affect the activity of narcotic analgesics. Despite that there are a large number of publications dealing with the problem, the obtained results are not being currently ...
V. M. Zhenilo, O. A. Makharin
doaj   +1 more source

Efficacy of energy‐based devices on episiotomy pain and healing: A systematic review and meta‐analysis

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Episiotomy is a common obstetric procedure often associated with significant postpartum pain and delayed wound healing. Conventional treatments provide limited relief and might not be suitable for all women. Energy‐based therapies, including infrared irradiation and low‐level laser therapy (LLLT), a non‐thermal photo biomodulation ...
Shira Regev‐Sadeh   +4 more
wiley   +1 more source

BIOME cohort: Multi‐system microbiome dynamics and clinical outcomes in massive burn injury patients

open access: yesiMeta, EarlyView.
Massive burn injuries (MBIs) are associated with high mortality and disability rates, primarily due to microbial‐driven sepsis from extensive skin barrier loss and subsequent scar formation. This makes MBI a compelling model for studying multi‐system microbial dysbiosis following skin barrier destruction.
Runzhi Huang   +72 more
wiley   +1 more source

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