Results 91 to 100 of about 21,048 (272)

Opioid receptors in cardiovascular function

open access: yesBritish Journal of Pharmacology, EarlyView.
Opioid receptors are G protein‐coupled receptors expressed by various cells in the heart, including myocytes and nerve fibres, and play a crucial role in modulating cardiac function. These receptors influence neural transmission, heart rate and myocyte contractility, offering cardioprotection.
Venkatesh Katari   +4 more
wiley   +1 more source

GPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger

open access: yesBritish Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.
Chenlin Feng   +3 more
wiley   +1 more source

Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
This consensus highlights critical research gaps in obesity epidemiology, phenotypic heterogeneity and clinical management, calling for advanced methodologies, collaborative strategies and innovative policies to mitigate the global obesity epidemic and its socio‐economic impacts.
Federico Carbone   +28 more
wiley   +1 more source

Autoimmunity in MASLD: Focus on autoantibodies, anti‐apolipoprotein A1 IgG and G protein‐coupled receptors

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
This review outlines the potential role of anti‐GPCR autoantibodies in MASLD/MASH, given their involvement in a wide range of diseases and their possible contribution to MASLD/MASH pathophysiology. We also focused on anti‐ApoA1 autoantibodies, sharing functional features with anti‐GPCR autoantibodies and have been shown to promote liver steatosis in ...
Sabrina Pagano   +3 more
wiley   +1 more source

In Vitro Analyses of Spinach-Derived Opioid Peptides, Rubiscolins: Receptor Selectivity and Intracellular Activities through G Protein- and β-Arrestin-Mediated Pathways. [PDF]

open access: yesMolecules, 2021
Karasawa Y   +12 more
europepmc   +1 more source

Survey on 9 years of anti‐doping controls in horse races in Italy

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Doping in racehorses is a threat to horse welfare and the integrity of the sport. Despite its relevance, the literature on the prevalence of anti‐doping violations worldwide is limited. Objectives To analyse anti‐doping violations in racehorses in Italy. Study Design Retrospective observational study.
Mariana Roccaro   +5 more
wiley   +1 more source

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