Results 71 to 80 of about 416,668 (254)

Molecular and cellular mechanisms of the age-dependency of opioid analgesia and tolerance

Molecular Pain, 2012
The age-dependency of opioid analgesia and tolerance has been noticed in both clinical observation and laboratory studies. Evidence shows that many molecular and cellular events that play essential roles in opioid analgesia and tolerance are actually age-
Zhao Jing, Xin Xin, Xie Guo-xi, Palmer Pamela, Huang Yu-guang   +4 more
doaj   +1 more source

National opioid pharmacotherapy statistics 2014 [PDF]

, 2015
Summary Dependence on opioid drugs is associated with a range of health and social problems that affect individual drug users, their family and friends, and the wider public.
Australian Institute of Health and Welfare
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Opiate agonists and antagonists modulate taste perception in opiate-maintained, and recently detoxified subjects. [PDF]

, 2013
Heroin addicts consume large quantities of refined sugars. This study investigated the effect of opiate use and antagonism on sweet taste in opiate-maintained drug users and detoxified former chronic opiate users, using a within-subject design.
Green, Amy, Mullings, Emma L, Sharma, Ekta, Nutt, David J, Melichar, Jan K, O’Shea, Jacinta, Munafò, Marcus R., Bennett, Lisa, Donaldson, Lucy F., Nutt, David J., Donaldson, Lucy F, O'Shea, Jacinta, Munafò, Marcus R, Melichar, Jan K., Kaul, Arun   +14 more
core   +1 more source

Chronic Disease and Disability in the United States: Trends, Inequities, and Imperatives for Policy Reform

The Milbank Quarterly, EarlyView.
Policy Points Position Universal, High‐Quality Education as a Foundational Public Health Strategy. Long‐term health and life expectancy in the United States are shaped more by educational attainment than by any other single factor. Disparities in access to early childhood, K‐12, and higher education perpetuate cycles of chronic disease, economic ...
ALI H. MOKDAD, LAURA DWYER‐LINDGREN, CHRISTOPHER J.L. MURRAY   +2 more
wiley   +1 more source

Hepatoprotective effect of opioid peptides in stress [PDF]

Research Results in Pharmacology, 2019
Introduction: Influence of the endogenous opioid system on the liver has not been studied enough. To understand the damaging effects of stress on the liver and the hepatoprotective effects of opioids, a study was performed on stress-resistant and stress ...
Alexey V. Solin, Yury D. Lyashev, Nikolay V. Tsygan   +2 more
doaj   +3 more sources

Smoking Abstinence Elicits Hyperalgesia: Neural Mechanism, Clinical Implications, and Pharmacological Managements. [PDF]

CNS Neurosci Ther
The cycle between nicotine use and pain modulation. Cigarette smoking leads to nicotine entering the body, which binds to nicotinic acetylcholine receptors (nAChRs) in the brain, triggering the release of different neurotransmitters, including dopamine (DA), norepinephrine (NE), serotonin (5‐HT), and GABA.
Hu SS, Zhang CF, Lkhagvasuren B, Wang D.
europepmc   +2 more sources

Naloxone antagonizes the local antihyperalgesic effect of fentanyl in burnt skin of healthy humans [PDF]

, 2007
The aim of this study was to investigate local opioid effects in the inflamed skin of healthy human volunteers. To induce inflammation, the circular tip of a 10-mm-diameter probe was heated to 48°C and applied for 120 seconds to a site on each forearm of
Hammond, G.R., Drummond, P.D., Robertson, L.   +2 more
core  

Opioid peptides in the female reproductive system: physiological implications [PDF]

, 1995
All endogenous opioid peptides derive from three precursor molecules i.e. proopiomelanocortin, proenkephalin and prodynorphin. The endogenous opioid peptides exert their biological effects through opioid receptors. Each endogenous opioid peptide exhibits
Makrigiannakis, Antonis; University of Crete, Gravanis, Achille; University of Crete, Margioris, Andrew N.; University of Crete, Stournaras, Christos; University of Crete   +3 more
core   +1 more source

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean‐Christoph Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

The Role of Opioids on Motor Activity in Physio-pathological Conditions [PDF]

, 2009
To date, four principal classes of opioid peptide receptors, μ (MOP), κ (KOP), δ (DOP) and ORL- 1 (NOP) have been identified and cloned. The experimental and clinical importance of this receptor family has been amply demonstrated in many diseases ...
Mabrouk, Omar Sharif
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