Results 121 to 130 of about 416,668 (254)

Osteoarthritis Therapeutics: From Microenvironment Understanding to Regenerative Intervention—Current Advances and Future Perspectives

Orthopaedic Surgery, EarlyView.
This article outlines a paradigm shift in OA therapeutics, OA as a systemic disease of joint microenvironment imbalance. It synthesizes advances in targeting key pathological hubs—immune, metabolic, and senescent—and details novel regenerative strategies using engineered biomaterials and exosomes.
Yongbiao Meng, Shenghua Wu, Quanchun Liu
wiley   +1 more source

Comparative Effectiveness of GLP‐1RAs, SGLT2is and DPP4is for Cardiovascular Outcomes in Type 2 Diabetes: An Empirically Calibrated Target Trial Emulation Study

Diabetes, Obesity and Metabolism, EarlyView.
Bingyu Zhang, Ting Zhou, Huilin Tang, Yiwen Lu, Dazheng Zhang, Jiajie Chen, Tianchu Lyu, Kai Zheng, David A. Asch, Yong Chen   +9 more
wiley   +1 more source

TRIP8bnano peptide prevents cAMP binding to HCN2 channels alleviating pain‐like behaviors in rats with neuropathic pain

The Journal of Physiology, EarlyView.
Abstract figure legend We tested the hypothesis that cAMP binding to HCN2 channels in nociceptors is a causal driver of neuropathic pain by using TRIP8bnano, a synthetic peptide we previously developed as a selective antagonist of cAMP in HCN channels. TRIP8bnano effectively abolishes cAMP potentiation of HCN2 currents in small‐diameter DRG neurons and
Santiago I. Loya‐Lopez, Kimberly Gomez, Alessandro Porro, Gerhard Thiel, Anna Moroni, Heather N. Allen, Rajesh Khanna, Andrea Saponaro   +7 more
wiley   +1 more source

Degradation of food-derived opioid peptides by bifidobacteria

, 2018
Some food-derived opioid peptides have been reported to cause diseases, such as gastrointestinal inflammation, celiac disease, and mental disorders.
N. Hashikura, J.-Z. Xiao, A. Yamada, T. Sakurai, T. Odamaki   +4 more
core   +1 more source

The last‐step integrator thesis: Heterarchical control of the mammalian gastrointestinal tract

The Journal of Physiology, EarlyView.
Abstract figure legend Heterarchy of control of the gastrointestinal tract. The production mechanisms (i.e. epithelial cells and muscles) are shown at the bottom in green. Above them are some of the many mechanisms that provide control inputs to these production mechanisms.
William Bechtel, Leonardo Bich
wiley   +1 more source

Advances in the Design and Functionality of a Compact Multi‐Reflecting Time‐of‐Flight Mass Spectrometer

Rapid Communications in Mass Spectrometry, Volume 40, Issue 22, 30 November 2026.
ABSTRACT Rationale High‐resolution mass spectrometry is routinely used for the analysis of complex samples in pharmaceutical, environmental, and omics related studies. Such applications demand instrumentation to be capable of combining sub‐ppm mass accuracy, high resolving power, rapid full m/z range acquisition over a wide dynamic range.
Jason Wildgoose, Samantha Ferries, Lee A. Gethings, Matthew E. Daly, Martin E. Palmer, Richard Lock, Johannes P. C. Vissers, James I. Langridge   +7 more
wiley   +1 more source

Social trauma and the mu-opioid system in depression [PDF]

, 2011
The overarching thesis under investigation is that the endogenous opioid system plays a key role in depression subsequent to traumatic childhood social experiences. This is suggested by the fact that animal work indicates that mu-opioids robustly mediate
Malcolm-Smith, Susan
core   +1 more source

Peptidomics and pharmacological profiling of Odontobuthus doriae (Buthidae) scorpion venom at the kappa opioid receptor

Scientific Reports
Scorpion venoms are rich in bioactive peptides, many of which act on ion channels and neurotransmitter systems, yet their capacity to interact with G protein-coupled receptors (GPCRs) has been largely unexplored.
Adel Abdollahnia, Boglarka Blanka Bata, Andreas Fraunhofer, Julius Hermes, Javad Atashi, Alireza Ghassempour, Christian W. Gruber   +6 more
doaj   +1 more source

The Role of Endogenous Beta-Endorphin and Enkephalins in the Crosstalk Between Ethanol and Morphine

Pharmaceuticals
Background: There is clinical concern about the combined use of alcohol and opiates. Several lines of evidence support an interaction between alcohol and the endogenous opioid system.
Andy Tseng, Syed Muzzammil Ahmad, Abdul Hamid, Kabirullah Lutfy   +3 more
doaj   +1 more source

Opioid analgesics, opioid abuse

, 2018
Átfogó irodalmi áttekintésként diplomamunkámban bemutatom az opioid szerek terápiás jelentőségét, az opioid receptorok szerepét és az opiátabúzus hátterében lévő mechanizmusokat.
Burai, Dóra
core