Results 121 to 130 of about 21,347 (246)

TRIP8bnano peptide prevents cAMP binding to HCN2 channels alleviating pain‐like behaviors in rats with neuropathic pain

The Journal of Physiology, EarlyView.
Abstract figure legend We tested the hypothesis that cAMP binding to HCN2 channels in nociceptors is a causal driver of neuropathic pain by using TRIP8bnano, a synthetic peptide we previously developed as a selective antagonist of cAMP in HCN channels. TRIP8bnano effectively abolishes cAMP potentiation of HCN2 currents in small‐diameter DRG neurons and
Santiago I. Loya‐Lopez, Kimberly Gomez, Alessandro Porro, Gerhard Thiel, Anna Moroni, Heather N. Allen, Rajesh Khanna, Andrea Saponaro   +7 more
wiley   +1 more source

Endogenous μ-opioid peptides modulate immune response towards malignant melanoma

, 2010
Opioids exert major effects not only in the central nervous system but also in immune responses. We investigated the effects of mu-opioid peptides, secreted by tumor cells, on anti-tumor immune responses.
Katja Hardt, Duthey, Beatrice, Boehncke, Wolf-Henning, Sandra Boehncke, Beatrice Duthey, Dirk Schadendorf, Hardt, Katja, Reinhard Henschler, Wolf-Henning Boehncke, Henschler, Reinhard, Schadendorf, Dirk, Boehncke, Sandra   +11 more
core   +1 more source

Brain sparing in fetal growth restriction: The double‐edged sword of fetal hypoxaemia

The Journal of Physiology, EarlyView.
Abstract figure legend The double‐edged sword of brain sparing. Fetal hypoxaemia triggers a coordinated adaptive response characterised by redistribution of cardiac output toward essential organs, including the brain, and a reduction in overall metabolic activity to preserve oxygen supply.
Beth J. Allison, Tegan A. White, Emily J. Camm, Suzanne L. Miller   +3 more
wiley   +1 more source

The endogenous antagonists of opioid peptides in the management of hemorrhagic shock.

, 1989
The endogenous antagonists of opioid peptides in the management of hemorrhagic ...
BAZZANI, Carla, GUARINI, Salvatore, FERRARI, William, BERTOLINI, Alfio, S. TAGLIAVINI   +4 more
core  

A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain Via Notochordal Cell Loss and Pain‐Inducing Nucleus Pulposus Cell Emergence

JOR SPINE, Volume 9, Issue 3, September 2026.
A porcine model of disc injury recapitulates key clinical, histological, and molecular features of human discogenic low back pain. Multi‐omics analyses identify a shift from notochordal cells to pain‐associated nucleus pulposus cells as a potential driver of disease progression. ABSTRACT Background Lower back pain (LBP) is one of the most common causes
Giselle Kaneda, Jacob T. Wechsler, Melissa Chavez, Julia Sheyn, Karandeep Cheema, Chushu Shen, Dante Rigo De Righi, Lixia Wang, Yin‐Chen Hsu, Pablo Avalos, Yibin Xie, Wafa Tawackoli, Candace Floyd, Debiao Li, Dmitriy Sheyn   +14 more
wiley   +1 more source

Neuro-physiological characterization of opioid peptide actions on neurohumoral transmission in the mammalian central nervous system [PDF]

, 1986
Mercuri, Nicola, Zieglgänsberger, Walter, Stefano, George B., Stanzione, Paolo, Sutor, Bernd   +4 more
core   +1 more source

OVARIAN SECRETION OF OPIOID-PEPTIDES - EVIDENCE OF A CORRELATION WITH THE OVARIAN-FUNCTION

, 1985
OVARIAN SECRETION OF OPIOID-PEPTIDES - EVIDENCE OF A CORRELATION WITH THE OVARIAN ...
FACCHINETTI, Fabio, PETRAGLIA F., RUSPA M   +2 more
core  

Deciphering the Function and Structure of PA1216 as an S‐Adenosyl‐l‐Methionine Binding Protein Using Differential Scanning Fluorimetry and Circular Dichroism

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Microbes produce bioactive secondary metabolites as toxins, pigments, or virulence factors. These specialized compounds are produced by nonribosomal peptide synthetases (NRPS), polyketide synthases (PKS), or hybrid NRPS/PKS pathways. The genes encoding NRPS and PKS reside in biosynthetic gene clusters (BGCs), some of which have no identified ...
Amaan M. Fruitwala, Jade X. Tiszler, Daniel Watson, Mansi Sinha, Tony D. Davis   +4 more
wiley   +1 more source

The Role of Endogenous Beta-Endorphin and Enkephalins in the Crosstalk Between Ethanol and Morphine

Pharmaceuticals
Background: There is clinical concern about the combined use of alcohol and opiates. Several lines of evidence support an interaction between alcohol and the endogenous opioid system.
Andy Tseng, Syed Muzzammil Ahmad, Abdul Hamid, Kabirullah Lutfy   +3 more
doaj   +1 more source

Peri‐operative management of diabetes mellitus: a multidisciplinary consensus statement from the Association of Anaesthetists and the Joint British Diabetes Societies for Inpatient Care group

Anaesthesia, Volume 81, Issue 8, Page 1116-1131, August 2026.
Summary Introduction Surgery in patients with diabetes mellitus is associated with increased morbidity and mortality compared with those who do not have diabetes mellitus. This is likely multifactorial and could be attributed to organisational issues; dysglycaemia; hospital‐acquired diabetic ketoacidosis; errors with insulin prescribing and ...
Nicholas A. Levy, Kariem El‐Boghdadly, Dileep N. Lobo, Daniel J. Stubbs, Parizad Avari, Donal Buggy, Claire Frank, Kim Howson, Jinty Moffett, Emma Morris, Omar G. Mustafa, Glynn Nash, Pádraig Ó Scanaill, Sarah Procter, Gerry Rayman, Kim Russon, Caroline Thomas, Sarah Tinsley, Allan Xu, Ketan Dhatariya   +19 more
wiley   +1 more source