Results 141 to 150 of about 448,610 (243)
Leukocyte opioid receptors mediate analgesia via Ca 2+ -regulated release of opioid peptides
, 2016 Opioids are the most powerful analgesics. As pain is driven by sensory transmission and opioid receptors couple to inhibitory G proteins, according to the classical concept, opioids alleviate pain by activating receptors on neurons and blocking the ...
Celik, Melih Ö. +15 more
core +1 more source
British Journal of Pharmacology, Volume 183, Issue 23, Page 6865-6882, December 2026.Background and Purpose G protein‐coupled receptors (GPCRs) are major drug targets, yet many orphan receptors remain poorly characterized. GPR139 has been implicated in CNS disorders, including schizophrenia and depression, but its signalling mechanisms remain unclear.
Boris Trapkov +2 more
wiley +1 more source
Endogenous opioid peptides in the descending pain modulatory circuit. [PDF]
Neuropharmacology, 2020 Bagley EE, Ingram SL.
europepmc +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11143-11177, December 2026.ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding +4 more
wiley +1 more source
Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions. [PDF]
Mol Pharmacol, 2020 Fricker LD +3 more
europepmc +1 more source
Naloxone antagonizes the local antihyperalgesic effect of fentanyl in burnt skin of healthy humans [PDF]
, 2007 The aim of this study was to investigate local opioid effects in the inflamed skin of healthy human volunteers. To induce inflammation, the circular tip of a 10-mm-diameter probe was heated to 48°C and applied for 120 seconds to a site on each forearm of
Hammond, G.R. +2 more
core
Rapid Communications in Mass Spectrometry, Volume 40, Issue 22, 30 November 2026.ABSTRACT Rationale High‐resolution mass spectrometry is routinely used for the analysis of complex samples in pharmaceutical, environmental, and omics related studies. Such applications demand instrumentation to be capable of combining sub‐ppm mass accuracy, high resolving power, rapid full m/z range acquisition over a wide dynamic range.
Jason Wildgoose +7 more
wiley +1 more source
Design, Synthesis and Functional Analysis of Cyclic Opioid Peptides with Dmt-Tic Pharmacophore. [PDF]
Molecules, 2020 Sarkar A +6 more
europepmc +1 more source
THE NEUROENDOCRINOLOGY OF OPIOID PEPTIDES
British Medical Bulletin, 1983 Grossman, A, Rees, L
openaire +3 more sources
Proto‐Panic Modulation by Caffeine‐Proteinoid Complexes
Journal of Applied Polymer Science, Volume 143, Issue 41, November 5, 2026.Caffeine–proteinoid microspheres synthesized by thermal polymerization exhibit compartmentalized drug loading with encapsulation efficiencies of 61%–82% and triphasic release kinetics. Electrochemical monitoring reveals multi‐scale oscillatory dynamics consistent with chaotic and damped harmonic behavior, while Boolean logic operations demonstrate ...
Panagiotis Mougkogiannis +1 more
wiley +1 more source