Chronic stress differentially alters mRNA expression of opioid peptides and receptors in the dorsal hippocampus of female and male rats. [PDF]
J Comp Neurol, 2021 Johnson MA +8 more
europepmc +1 more source
Chronic Diseases and Translational Medicine, Volume 12, Issue 3, Page 183-196, September 2026.Pharmacological mechanisms and physiologic effects of GLP‐1 receptor agonists relevant to peri‐endoscopic risk. ABSTRACT The global increase in obesity, type 2 diabetes mellitus (T2DM), and metabolic dysfunction‐associated steatotic liver disease (MASLD) has led to a higher use of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) among patients ...
Junaid Beig +7 more
wiley +1 more source
Endogenous opioid peptides in the descending pain modulatory circuit. [PDF]
Neuropharmacology, 2020 Bagley EE, Ingram SL.
europepmc +1 more source
Cancer‐related pain: A bidirectional modulator of cancer progression
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.CRP and tumour progression engage in a dynamic, bidirectional circuit mediated by multiple mechanisms involving neuroimmunology and cancer ‐neuroscience. Analgesic interventions may affect tumour progression, while anticancer therapies can influence pain. Targeting pain in cancer may have promising therapeutic value in cancer progression.
Junzhe He +5 more
wiley +1 more source
Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions. [PDF]
Mol Pharmacol, 2020 Fricker LD +3 more
europepmc +1 more source
Observations of the Opioid Workgroup of the Board of Scientific Counselors of the National Center for Injury Prevention and Control on the updated CDC Guideline for prescribing opioids [PDF]
Observations on CDC Guideline for Prescribing Opioids \u2013 United States, 2022This document outlines the observations of the Opioid Workgroup on the updated CDC Guideline for Prescribing Opioids.
core
Combination Pharmacotherapies for Obesity—Current Evidence and Future Directions
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.Combination pharmacotherapy for obesity can enhance weight loss by targeting complementary neuroendocrine and metabolic pathways. Such benefits are largely additive but limited by tolerability, cost and access. This review outlines practical clinical archetypes and a research agenda for safer, more precise and durable combination strategies across ...
A. B. M. Kamrul‐Hasan +6 more
wiley +1 more source
Design, Synthesis and Functional Analysis of Cyclic Opioid Peptides with Dmt-Tic Pharmacophore. [PDF]
Molecules, 2020 Sarkar A +6 more
europepmc +1 more source
The Evolution of Medications for Obesity Management
JGH Open, Volume 10, Issue 9, September 2026.ABSTRACT This narrative review provides an overview of progress in the development of obesity medications, including a synthesis of data describing the efficacy and safety of currently available agents and emerging therapeutic options. Historically, many obesity medications have been withdrawn from the market due to safety concerns.
Jaskirath Gill, Priya Sumithran
wiley +1 more source
JOR SPINE, Volume 9, Issue 3, September 2026.A porcine model of disc injury recapitulates key clinical, histological, and molecular features of human discogenic low back pain. Multi‐omics analyses identify a shift from notochordal cells to pain‐associated nucleus pulposus cells as a potential driver of disease progression. ABSTRACT Background Lower back pain (LBP) is one of the most common causes
Giselle Kaneda +14 more
wiley +1 more source