Results 161 to 170 of about 448,610 (243)

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, Volume 65, Issue 42, 12 October 2026.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Met-enkephalin and other opioid peptides in the stress response of chickens: lessons from laboratory animals and livestock. [PDF]

Front Physiol
Pierzchała-Koziec K, Scanes CG.
europepmc   +1 more source

Fentanyl exposure during preconception and gestation permanently dysregulates endogenous opioid peptides and sympathoadrenal-medullary axis in the offspring. [PDF]

Clin Sci (Lond)
Ahmed N, Dalmasso C, Tavakoli NS, Peñalver Abed P, Turner MB, Czuba LC, Pautassi RM, Ortinski PI, Loria AS.   +8 more
europepmc   +1 more source

Dynorphin and Enkephalin Opioid Peptides and Transcripts in Spinal Cord and Dorsal Root Ganglion During Peripheral Inflammatory Hyperalgesia and Allodynia. [PDF]

J Pain, 2020
Sapio MR, Iadarola MJ, Loydpierson AJ, Kim JJ, Thierry-Mieg D, Thierry-Mieg J, Maric D, Mannes AJ.   +7 more
europepmc   +1 more source

The Expressing Patterns of Opioid Peptides, Anti-opioid Peptides and Their Receptors in the Central Nervous System Are Involved in Electroacupuncture Tolerance in Goats. [PDF]

Front Neurosci, 2018
Wan J, Qiu Z, Ding Y, Nan S, Ding M.
europepmc   +1 more source

Endogenous opioid peptides and brain development: Endomorphin-1 and Nociceptin play a sex-specific role in the control of oligodendrocyte maturation and brain myelination. [PDF]

Glia, 2020
Mohamed E, Paisley CE, Meyer LC, Bigbee JW, Sato-Bigbee C.   +4 more
europepmc   +1 more source

Opioid peptides, opioid receptors and mechanism of down regulation

, 2003
5-13Biogenesis of various endogenous opioid peptides, anatomical distribution and the characteristics of multiple receptors with which they interact provides an opportunity for understanding the role of opioid systems and mechanism of opioid ...
Chaturvedi, Kirti
core  

Opioid receptors and opioid peptides in the cardiomyogenesis of mouse embryonic stem cells. [PDF]

J Cell Physiol, 2019
Šínová R, Kudová J, Nešporová K, Nešporová K, Karel S, Šuláková R, Velebný V, Kubala L.   +7 more
europepmc   +1 more source

Equipotent enantiomers of cyclic opioid peptides at μ opioid receptor. [PDF]

Pept Sci (Hoboken), 2019
Weltrowska G, Nguyen TM, Chung NN, Wilkes BC, Schiller PW.   +4 more
europepmc   +1 more source

Role of Milk-Derived Opioid Peptides and Proline Dipeptidyl Peptidase-4 in Autism Spectrum Disorders. [PDF]

Nutrients, 2019
Jarmołowska B, Bukało M, Fiedorowicz E, Cieślińska A, Kordulewska NK, Moszyńska M, Świątecki A, Kostyra E.   +7 more
europepmc   +1 more source