Results 151 to 160 of about 448,610 (243)
Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1389-1401, November 2026.A mechanistic CNS PBPK model framework was applied to eight antipsychotic D2 receptor ligands, comparing brain extracellular fluid (brainECF) and brain cell membrane (brainM) as biophase for predicting human receptor occupancy compared against PET neuroimaging data. BrainM concentrations showed improved agreement with PET‐derived receptor occupancy for
Divakar Budda +2 more
wiley +1 more source
Antinociceptive and Cytotoxic Activity of Opioid Peptides with Hydrazone and Hydrazide Moieties at the C-Terminus. [PDF]
Molecules, 2020 Dyniewicz J +5 more
europepmc +1 more source
GLP‐1 Receptor Agonism Exacerbates Activity‐Based Anorexia in Mice
International Journal of Eating Disorders, Volume 59, Issue 11, Page 2549-2554, November 2026.ABSTRACT Objective Glucagon‐like peptide‐1 receptor (GLP‐1R) agonists reduce food intake and body weight, suggesting they should be avoided in anorexia nervosa. However, preclinical evidence that these drugs reduce activity and reward‐seeking behavior raises the possibility that they might attenuate the compulsive‐like hyperactivity central to ABA ...
Amit Thakar +2 more
wiley +1 more source
The Role of Astrocytes in the Inflammatory Response in Neurodiseases
MedComm, Volume 7, Issue 11, November 2026.Reactive astrocyte‐mediated pathogenic mechanisms in neurodegenerative diseases Schematic representation of key astrocytic pathways contributing to pathology in the pathogenesis of AD, PD, ALS, and HD. In AD, astrocytes exhibit Aβ plaque‐associated activation characterized by GFAP/S100β upregulation, accompanied by impaired EAAT2‐mediated glutamate ...
Shijun Peng +3 more
wiley +1 more source
MedComm, Volume 7, Issue 11, November 2026.This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin +6 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11971-11977, December 2026.
Bingyu Zhang +9 more
wiley +1 more source
Pharmacoepidemiology and Drug Safety, Volume 35, Issue 11, November 2026.ABSTRACT Purpose SGLT2 inhibitors (SGLT2i) and GLP‐1 receptor agonists (GLP‐1 RA) provide cardiovascular (CV) benefits, but their first‐line use among adults with severe mental illness (SMI) is not well characterized. We evaluated selective prescribing of SGLT2i, GLP‐1 RA, and metformin among adults with SMI and type 2 diabetes (T2D).
Yueh‐Yi Chiang +5 more
wiley +1 more source
Enhancement of hippocampal synaptic AMPA receptor function by the antidepressant tianeptine and by opioid peptides. [PDF]
Proc Natl Acad Sci U S AMariano A +10 more
europepmc +1 more source
Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects
European Journal of Neuroscience, Volume 64, Issue 9, November 2026.Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Daniela Novakova +2 more
wiley +1 more source
Opioid peptides in autism spectrum disorder and gluten-free casein-free diet as a therapeutic approach. [PDF]
Metab Brain DisÖztürk E +3 more
europepmc +1 more source