Results 131 to 140 of about 416,668 (254)

Determining the impact of opioid substitution therapy upon mortality and recidivism among prisoners: a 22 year data linkage study [PDF]

, 2014
Foreword: Prisoners experience high rates of drug dependence, health problems and premature mortality. Without intervention, they often come into further contact with the criminal justice system, creating further health risk.
Natasa Gisev, Weatherburn, Don J., Burns, L., Lucy Burns, Louisa Degenhardt, Degenhardt, L., Gisev, Natasha, Mattick, R., Tony Butler, Weatherburn, Don, Kimber, J., Don Weatherburn, Kimber, Jo, Degenhardt, Louisa, Amy Gibson, Gisev, N., Larney, S ; https://orcid.org/, Gibson, Amy (R17420), Burns, Lucy, Larney, Sarah, Richard Mattick, Butler, Tony, Weatherburn, D., Dobbins, Tim, Gisev, N ; https://orcid.org/, Degenhardt, L ; https://orcid.org/, Tim Dobbins, Gibson, Amy, Weatherburn, D, Gibson, A., Mattick, RP, Larney, S., Gisev, Natasa, Jo Kimber, Dobbins, T ; https://orcid.org/, Mattick, Richard P., Dobbins, T., Sarah Larney, Kimber, J, Burns, L ; https://orcid.org/, Gibson, A ; https://orcid.org/, Butler, T ; https://orcid.org/, Dobbins, Timothy A., Mattick, Richard   +43 more
core   +1 more source

Prescription Sequence Symmetry Analysis of Glucagon‐Like Peptide‐1 Receptor Agonists and Neuropsychiatric Conditions

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 1092-1100, October 2026.
Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) are increasingly prescribed for type 2 diabetes and weight management. However, conflicting evidence from preclinical, clinical, and pharmacovigilance studies suggests potential neuropsychiatric effects.
Maria J. Alfonso Arvez, Sam Wade, Darshna Goordeen, Jenni Ilomäki, Amanda J. Cross, Monica Langiu, George S. Q. Tan   +6 more
wiley   +1 more source

THE EFFECT OF VASOPRESSIN IN ACUPUNCTURE ANALGESIUA

针刺研究, 1988
Arg-Vasopressin (AVP)has obvious analgesic effect.This effect is not depressed by nalxone (NX),an antagonist of opiate receptor.It was observed that concentration of Leu-enkephalin (LEK) was decreased and catecholamines (CAS) were elevated ...
Liu Qi Han Wei Zhao Jianzhu
doaj  

The influence of discouragement, anxiety and anger on pain: an examination of the role of endogenous opioids [PDF]

, 2005
Animal research suggests that exposure to inescapable stressors can lead to an endogenous opioid-mediated form of pain inhibition, known as stress-induced analgesia (SIA).
Frew, Ashley Kim
core  

Mechanism‐Informed Pharmacotherapy Optimization and Deprescribing: A Redox–Mitochondrial Framework

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
From cumulative drug burden to mitochondrial stress and functional decline. The graphical abstract summarizes the central concept of the review, illustrating how cumulative pharmacotherapy exposure may contribute to redox–mitochondrial stress and thereby reduce biological and functional resilience.
Boštjan Martinc
wiley   +1 more source

Neuro-physiological characterization of opioid peptide actions on neurohumoral transmission in the mammalian central nervous system [PDF]

, 1986
Mercuri, Nicola, Zieglgänsberger, Walter, Stefano, George B., Stanzione, Paolo, Sutor, Bernd   +4 more
core   +1 more source

MDR1 P-glycoprotein transports endogenous opioid peptides

, 2001
MDR1 P-glycoprotein is generally regarded as an efflux pump for amphipathic toxic compounds. The question remains, however, whether certain endogenous compounds are also substrates for this transporter.
Zadina, J., James Zadina, Oude Elferink, R. P., Ronald P.J Oude Elferink   +3 more
core   +1 more source

MCH‐Guard: Multimodal machine learning framework for risk stratification of cerebral microhemorrhage risk in the Alzheimer's Disease Neuroimaging Initiative

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Efficient cerebral microhemorrhage (MCH) monitoring is critical for anti‐amyloid therapy safety due to amyloid‐related imaging abnormalities with hemosiderin deposition (ARIA‐H) risk. We developed MCH‐Guard, a multimodal machine‐learning framework, to stratify MCH risk for Alzheimer's Disease Neuroimaging Initiaitive (ADNI ...
Alper Gel, Eliana Phillips, Isabella Hausle, Pamela Thropp, Duygu Tosun, for the Alzheimer's Disease Neuroimaging Initiative   +5 more
wiley   +1 more source

In Vitro Analyses of Spinach-Derived Opioid Peptides, Rubiscolins: Receptor Selectivity and Intracellular Activities through G Protein- and β-Arrestin-Mediated Pathways. [PDF]

Molecules, 2021
Karasawa Y, Miyano K, Fujii H, Mizuguchi T, Kuroda Y, Nonaka M, Komatsu A, Ohshima K, Yamaguchi M, Yamaguchi K, Iseki M, Uezono Y, Hayashida M.   +12 more
europepmc   +1 more source

Comorbidity Mechanism and Management of Chronic Low Back Pain and Major Depressive Disorder: From Neural Circuit Remodeling to Precision Medicine

Brain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Objective This review systematically elaborates multi‐system interactive mechanisms underlying comorbid chronic low back pain (CLBP) and major depressive disorder (MDD), synthesizes recent advances in diagnosis, treatment, and management, and proposes precision medicine directions to address clinical challenges, including missed diagnosis ...
Lin Faqu, Lin Chenjuan, Xiang Xiangyin, Li Xin   +3 more
wiley   +1 more source