Results 221 to 230 of about 1,054,479 (288)

Opioid Peptides and their Receptors

1982
The three agonists, methionine-enkephalin, leucine-enkephalin and beta-endorphin have different pharmacological patterns. It may be of particular importance that they vary in their relative affinities to the enkephalin and naltrexone binding sites in the brain; the former are probably related to delta-receptors prevalent in the mouse vas deferens and ...
H.W. Kosterlitz, S.J. Paterson, L.E. Robson   +2 more
openaire   +3 more sources

Non-opioid actions of opioid peptides

Life Sciences, 2004
Beside the well known actions of opioid peptides on mu-, delta- and kappa-opioid receptors, increasing amount of pharmacological and biochemical evidence has recently been published about non-opioid actions of various opioid peptides. These effects are not abolished by naloxone treatments.
Maria Wollemann, Sándor Benyhe
openaire   +3 more sources

Evaluation of fritless solid‐phase extraction coupled on‐line with capillary electrophoresis‐mass spectrometry for the analysis of opioid peptides in cerebrospinal fluid

Electrophoresis, 2014
Fritless SPE on‐line coupled to CE with UV and MS detection (SPE‐CE‐UV and SPE‐CE‐MS) was evaluated for the analysis of opioid peptides. A microcartridge of 150 μm id was packed with a C18 sorbent (particle size > 50 μm), which was retained between a ...
Silvia Medina-Casanellas, Y. H. Tak, F. Benavente, V. Sanz-Nebot, J. S. Toraño, G. Somsen, G. D. de Jong   +6 more
semanticscholar   +1 more source

Immunomodulatory effects of endogenous and synthetic peptides activating opioid receptors.

Mini-Reviews in Medical Chemistry, 2014
The main role of endogenous opioid peptides is the modulation of pain. Opioid peptides exert their analgesic activity by binding to the opioid receptors distributed widely in the central nervous system (CNS).
D. Pomorska, K. Gach, A. Janecka
semanticscholar   +1 more source

Biosynthesis and distribution of opioid peptides [PDF]

Journal of Endocrinological Investigation, 1983
Group III opioid peptides are derived from proenkephalin B. The processing of this precursor peptide is still only partly understood and we still do not know how many final products come from proenkephalin B and whether Leu-enkephalin is produced from Group III peptides.
I. Tanaka, Yoshikatsu Nakai, Hiroo Imura, Takaaki Yoshimasa, Toshihiko Tsukada, Michio Suda, Hisato Jingami, Kazuwa Nakao, Shogo Oki, Makoto Sakamoto, Yoshio Ikeda   +10 more
openaire   +2 more sources

Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons.

Science, 1979
The atypical excitation by opiates and opioid peptides of hippocampal pyramidal cells can be antagonized by iontophoresis of naloxone, the gamma-aminobutyric acid antagonists bicuculline, or magnesium ion.
W. Zieglgänsberger, W. Zieglgänsberger, E. French, G. Siggins, F. Bloom   +4 more
semanticscholar   +1 more source

Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity.

Science, 1984
The cytotoxic activity of natural killer cells was investigated in rats subjected to one of two inescapable footshock stress paradigms, both of which induce analgesia, but only one via activation of opioid mechanisms. Splenic natural killer cell activity
Y. Shavit, J. Lewis, G. Terman, R. Gale, J. Liebeskind   +4 more
semanticscholar   +1 more source

Separation of opioid peptides utilizing high performance liquid chromatography.

International journal of peptide & protein research, 2009
Chromatographic procedures have been developed for resolving all of the known enkephalins and endorphins on a single column. The effect of eluant pH on the retention times and separation of the enkephalins and beta-endorphin was determined.
R. Lewis, S. Stein, S. Udenfriend
semanticscholar   +1 more source

Expression of Opioid Peptides in Tumors

New England Journal of Medicine, 1987
We looked for opioid peptides and their precursors in 108 tumors of both neuroendocrine and nonneuroendocrine origin, using a monoclonal "pan-opioid" antibody, 3-E7, which recognizes the tetrapeptide Tyr-Gly-Gly-Phe (the sequence responsible for pharmacologic activity in all known opioid peptides), in conjunction with polyclonal antibodies directed ...
Klaus G. Bensch, David G. Bostwick, Eckard Weber, David R. Holmes, Jack D. Barchas, William E. Null   +5 more
openaire   +3 more sources

Effect of acute ethanol administration on the release of opioid peptides from the midbrain including the ventral tegmental area.

Alcoholism: Clinical and Experimental Research, 2009
BACKGROUND Experimental evidence suggests that ethanol alters the activity of the endogenous opioid peptide systems in a dose and brain-region dependent manner. These alterations may influence the processes of ethanol reward and reinforcement.
Samuel Jarjour, Li Bai, C. Gianoulakis
semanticscholar   +1 more source