Results 101 to 110 of about 2,382,231 (215)

Influence of the hypothalamic arcuate nucleus on intraocular pressure and the role of opioid peptides.

open access: yesPLoS ONE, 2014
BackgroundAn opioid peptide neuron/humoral feedback regulation might be involved in changes of intraocular pressure (IOP). The aims of this study are to investigate the effects of arcuate nucleus (ARC) and opioid peptides on intraocular pressure (IOP ...
Ji Jin, Guo-xu Xu, Zhi-lan Yuan
doaj   +1 more source

Trends in gabapentinoid prescribing: A nationwide Danish drug utilization study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Pregabalin and gabapentin are increasingly used for pain and other conditions. Concerns exist about overuse as well as potential misuse and abuse. To guide rational prescribing practices, we provide detailed nationwide data on the use of gabapentinoids in Denmark.
Anton Pottegård   +7 more
wiley   +1 more source

Endogenous opioids regulate moment-to-moment neuronal communication and excitability

open access: yesNature Communications, 2017
The endogenous opioid system regulates fear and anxiety, but the underlying cellular mechanism is unclear. Winterset al. shows that in the intercalated cells (ITC) of the amygdala, endogenous opioids suppress glutamatergic inputs via the δ-opioid ...
Bryony L. Winters   +9 more
doaj   +1 more source

EudraVigilance insights: Suspected adverse drug reactions in infants through breastfeeding

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims We aimed to describe suspected adverse drug reactions (ADRs) in infants resulting from medications transmitted through mothers' milk, as reported to the European ADR database, EudraVigilance. The research sought to understand the frequency, seriousness and nature of these ADRs to assess potential risks associated with maternal medication use ...
Ida M. Heerfordt   +7 more
wiley   +1 more source

Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase

open access: yesNature Communications, 2017
Opioid receptors are important modulators of nociceptive pain. Here the authors show that opioid receptor activation recruits peroxiredoxin 6 (PRDX6) to the receptor-Gαi complex by c-Jun N-terminal kinase, resulting in Gαi depalmitoylation and enhanced ...
Selena S. Schattauer   +8 more
doaj   +1 more source

A mu–delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks

open access: yesBrain Structure and Function, 2014
Opioid receptors are G protein-coupled receptors (GPCRs) that modulate brain function at all levels of neural integration, including autonomic, sensory, emotional and cognitive processing.
E. Erbs   +14 more
semanticscholar   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

open access: yesBMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah   +9 more
wiley   +1 more source

Deletion of arrestin-3 does not reduce drug-seeking behavior in a longitudinal paradigm of oral morphine self-administration

open access: yesFrontiers in Pharmacology
IntroductionOpioid drugs are potent analgesics that mimic the endogenous opioid peptides, endorphins and enkephalins, by activating the µ-opioid receptor.
Sarah Warren Gooding   +12 more
doaj   +1 more source

Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia.

open access: yesJournal of Clinical Investigation, 2014
The development of opioid-induced analgesic tolerance and hyperalgesia is a clinical challenge for managing chronic pain. Adaptive changes in protein translation in the nervous system are thought to promote opioid tolerance and hyperalgesia; however, how
Ji-Tian Xu   +12 more
semanticscholar   +1 more source

Variation in the infant health effects of the women, infants, and children program by predicted risk using novel machine learning methods

open access: yesHealth Economics, Volume 32, Issue 1, Page 194-217, January 2023., 2023
Abstract The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) has an extensive literature documenting positive effects on infant health outcomes, specifically preterm birth, low birthweight, small size for gestational age, and infant mortality.
Evan D. Peet   +3 more
wiley   +1 more source

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