Results 131 to 140 of about 2,382,231 (215)

High‐Throughput Drug Derivatization and Bioassay by Desorption Electrospray Ionization Mass Spectrometry

ChemPlusChem, EarlyView.
Accelerated drug derivatization in microdroplets combined with high‐throughput desorption electrospray ionization mass spectrometry provides rapid reaction screening and label‐free bioassay results, which can expedite drug discovery. Adapting high‐throughput (HT) synthetic methods to the modification of drugs and to testing of their bioactivity should ...
Jyotirmoy Ghosh, Nicolás M. Morato, Yunfei Feng, R. Graham Cooks   +3 more
wiley   +1 more source

Dose Determinations at Drug Approval Reviews: FDA‐Approved Drugs in Past 5 Years

Clinical Pharmacology &Therapeutics, EarlyView.
Drug dose appropriateness is one of the most discussed issues in regulatory reviews. We analyzed dose determinations during Food and Drug Administration (FDA) drug reviews to determine whether there were changes between the proposed and approved doses of new molecular entities (NMEs), including cases where postmarketing dose‐finding studies were ...
Sachiko Mita, Shunsuke Ono
wiley   +1 more source

Advancing access to Medicare‐funded mental health treatment during the opioid epidemic: A counselor advocacy analysis

Journal of Counseling &Development, Volume 101, Issue 1, Page 15-28, January 2023., 2023
Abstract Although advocacy is a priority for counseling professionals, little is known about counseling advocates’ participation in the legislative advocacy process. Recent legislation to address the opioid crisis allowed counseling advocates to provide public comments to advance counselor inclusion in the Medicare program.
Jordan B. Westcott, Matthew C. Fullen, Justin Jordan   +2 more
wiley   +1 more source

Drug‐Event Pairs as Indicators for the Detection of Adverse Drug Reactions during Hospitalization in Routinely Collected Electronic Data Sources

Clinical Pharmacology &Therapeutics, EarlyView.
Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification of ADRs in clinical practice, surveillance and research is essential to prevent further harm. The aim of this study was to assess the likelihood of drugs contributing to clinically important inpatient adverse events, in order to provide ...
Anna Maria Wermund, Annette Haerdtlein, Wolfgang Fehrmann, Clara Weglage, Tobias Dreischulte, Ulrich Jaehde   +5 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Treatment barriers and gender‐based perceptions: Establishing gender‐based treatment specialty facilities as a strategy to motivate South African young women to seek treatment for substance use disorders

Journal of Community Psychology, Volume 51, Issue 1, Page 182-200, January 2023., 2023
Abstract South Africa alongside other low‐middle‐income countries have been some of the hardest hit by the substance use scourge. The study sought to identify and measure treatment barriers among young adults (18–29 years) living with substance use disorders, and then examine the role of gender in the perception of treatment barriers, with a view to ...
Tichaenzana Nyashanu, Herbert Zirima
wiley   +1 more source

Uncovering New Therapeutic Targets for Amyotrophic Lateral Sclerosis and Neurological Diseases Using Real‐World Data

Clinical Pharmacology &Therapeutics, EarlyView.
Although attractive for relevance to real‐world scenarios, real‐world data (RWD) is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in neurological diseases such as the rare disease, amyotrophic lateral sclerosis (ALS), which has no disease‐modifying treatments ...
Mohammadali Alidoost, Jeremy Y. Huang, Georgia Dermentzaki, Anna S. Blazier, Giorgio Gaglia, Timothy R. Hammond, Francesca Frau, Mary Clare McCorry, Dimitry Ofengeim, Jennifer L. Wilson   +9 more
wiley   +1 more source

Insights into the interaction between hemorphins and δ-opioid receptor from molecular modeling

Frontiers in Molecular Biosciences
Hemorphins are short atypical opioid peptide fragments embedded in the β-chain of hemoglobin. They have received considerable attention recently due to their interaction with opioid receptors.
Priya Antony, Bincy Baby, Ranjit Vijayan, Ranjit Vijayan, Ranjit Vijayan   +4 more
doaj   +1 more source

Multianalyte Approach—Including Automated Preparation of Calibrators—for Validated Quantification of 82 Drugs in Whole Blood by Liquid Chromatography–Tandem Mass Spectrometry

Drug Testing and Analysis, EarlyView.
In forensic bioanalysis, often multianalyte approaches are used given their increased effectiveness but can be difficult to develop and maintain in the laboratory, for example, in terms of calibrator solution preparation. A fast, simple, and robust liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the quantification of 82 classic ...
Andrea E. Steuer, Maja Keller, Thomas Kraemer, Sandra N. Poetzsch   +3 more
wiley   +1 more source

Waxy‐ or Putty‐Like Materials as a Novel Drug Preparation for Synthetic Cannabinoid Receptor Agonists: Detection in Prisons and In Vitro Cannabinoid Receptor Activity

Drug Testing and Analysis, EarlyView.
Waxy‐ or putty‐like materials has emerged as a novel drug preparation for synthetic cannabinoids and other drugs in UK prisons. An in vitro CB1 bioassay was used to evaluate the CB1 activating potential of MDMB‐INACA and extracts from eight seized samples. MDMB‐INACA had moderate efficacy but low potency at CB1.
Axelle Timmerman, Marie H. Deventer, Rachael Andrews, Robert Reid, Victoria Marland, Darren Edwards, Christopher R. Pudney, Niamh Nic Daéid, Christophe P. Stove, Caitlyn Norman   +9 more
wiley   +1 more source