Results 131 to 140 of about 2,542,870 (405)

The synergistic effect of anticholinergic burden and depression on fall risk in older persons

British Journal of Clinical Pharmacology, EarlyView.
Aims Both anticholinergic burden (ACB) and depression are known to increase fall risk in older persons, next to increasing morbidity and mortality. However, the effect of depression on fall risk associated with ACB is unclear. This is relevant because several antidepressants have anticholinergic effects to some extent.
Raymond Salet, Nathalie van der Velde, Didi Rhebergen, Bob van de Loo, Lotta Seppala, Natasja M. van Schoor, Bruno Stricker, Marieke Henstra   +7 more
wiley   +1 more source

Deletion of arrestin-3 does not reduce drug-seeking behavior in a longitudinal paradigm of oral morphine self-administration

Frontiers in Pharmacology
IntroductionOpioid drugs are potent analgesics that mimic the endogenous opioid peptides, endorphins and enkephalins, by activating the µ-opioid receptor.
Sarah Warren Gooding, Lindsey Felth, Randi Foxall, Zachary Rosa, Kyle Ireton, Izabella Sall, Joshua Gipoor, Anirudh Gaur, Madeline King, Noah Dirks, Cheryl Allyne Whistler, Jennifer Lynne Whistler, Jennifer Lynne Whistler   +12 more
doaj   +1 more source

Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates [PDF]

, 2016
Fentanyl is a powerful opiate analgesic typically used for the treatment of severe and chronic pain, but its prescription is strongly limited by the well-documented side-effects.
Benyhe, Sa ́ndor, CARRADORI, Simone, Csaba To ̈mbo ̈ly, Erdei, Anna I., Ferenc O. ̈tvos, Ferenc Za ́dor, Fidanza, Lorenzo, Marzoli, Francesca, Mirzaie, Sako, MOLLICA, Adriano, MONTI, LUDOVICA, Moriello, Aniello Schiano, Novellino, Ettore, Petrocellis, Luciano De, PIERETTI, stefano, Samavati, Reza, STEFANUCCI, AZZURRA, Szabolcs Dvora ́csko, Szucs, Edina   +18 more
core   +1 more source

The Mu Opioid Receptor Promotes Opioid and Growth Factor-Induced Proliferation, Migration and Epithelial Mesenchymal Transition (EMT) in Human Lung Cancer

PLoS ONE, 2014
Recent epidemiologic studies implying differences in cancer recurrence based on anesthetic regimens raise the possibility that the mu opioid receptor (MOR) can influence cancer progression. Based on our previous observations that overexpression of MOR in
Frances E. Lennon, T. Mirzapoiazova, Bolot Mambetsariev, V. Poroyko, R. Salgia, J. Moss, P. Singleton   +6 more
semanticscholar   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase

Nature Communications, 2017
Opioid receptors are important modulators of nociceptive pain. Here the authors show that opioid receptor activation recruits peroxiredoxin 6 (PRDX6) to the receptor-Gαi complex by c-Jun N-terminal kinase, resulting in Gαi depalmitoylation and enhanced ...
Selena S. Schattauer, Benjamin B. Land, Kathryn L. Reichard, Antony D. Abraham, Lauren M. Burgeno, Jamie R. Kuhar, Paul E. M. Phillips, Shao En Ong, Charles Chavkin   +8 more
doaj   +1 more source

The Kappa Opioid Receptor: From Addiction to Depression, and Back

Frontiers in Psychiatry, 2014
Comorbidity is a major issue in psychiatry that notably associates with more severe symptoms, longer illness duration, and higher service utilization.
L. Lalanne, Gülebru Ayranci, B. Kieffer, Pierre-Eric Lutz   +3 more
semanticscholar   +1 more source

Optimizing Peripheral Nerve Block Placement in Hip Surgery: A Cadaveric Study Mapping the Posterior Cutaneous Innervation

Clinical Anatomy, EarlyView.
ABSTRACT Optimizing analgesia after hip surgery enables more rapid recovery. However, peripheral nerve blocks (PNBs) often fail to provide adequate pain relief in the posterolateral hip as they typically target the lateral cutaneous nerve of the thigh (LCNT).
Ziki Gurney, Kenneth Saw Kai Wei, Leia Boote, Daniel Gareth Stolady, Benjamin Fox, Alan R. Norrish   +5 more
wiley   +1 more source

Chemical Components of the Dried Latex of Euphorbia resinifera Berg and Its Medicinal Features

Chemistry &Biodiversity, EarlyView.
ABSTRACT A great deal of research has been carried out on the latex of Euphorbia resinifera Berg, which is an important source of several compounds of therapeutic and medicinal interest. Extraction, synthesis, and hemi synthesis pathways continue to reveal the existence of other new products with anticancer, antioxidant, antidiuretic, and antimalarial ...
Doaa Hammad, El‐Mahdi Ourhzif, Salha Hamri, Hafid Abderrafia, Mostafa Khouili, Maria Dolors Pujol   +5 more
wiley   +1 more source

Central Injection of Endomorphin-2, but not Endomorphin-1, Increases Food Intake in Chicks via μ1-opioid Receptors

The Journal of Poultry Science, 2007
The endogenous tetrapeptides endomorphin-1 and -2 are potent, selective μ-opioid receptor agonists in mammals. The present study was done to elucidate whether central injection of endomorphins enhances feeding behavior in chicks, and to investigate ...
Takashi Bungo, Koh-Ichi Dodo, Tomofumi Izumi   +2 more
doaj   +1 more source