Results 161 to 170 of about 2,513,925 (427)

A mu–delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks

Brain Structure and Function, 2014
Opioid receptors are G protein-coupled receptors (GPCRs) that modulate brain function at all levels of neural integration, including autonomic, sensory, emotional and cognitive processing.
E. Erbs, L. Faget, G. Scherrer, A. Matifas, D. Filliol, J. Vonesch, M. Koch, P. Kessler, D. Hentsch, M. Birling, M. Koutsourakis, Laurent Vasseur, P. Veinante, B. Kieffer, D. Massotte   +14 more
semanticscholar   +1 more source

Changes in Descending Pain Modulation During Anti–Tumor Necrosis Factor Therapy: A Prospective Study in Rheumatoid Arthritis and Spondyloarthritis

Arthritis &Rheumatology, EarlyView.
Objective In rheumatoid arthritis (RA) and spondyloarthritis (SpA), managing persistent pain remains challenging. Little is known regarding impaired pain pathways in these patients and the impact of biologic disease‐modifying antirheumatic drugs (bDMARDs).
Anne‐Priscille Trouvin, Arielle Simunek, Joël Coste, Terkia Medkour, Alice Combier, Lucile Poiroux, François Vidal, Sandrine Carvès, Didier Bouhassira, Serge Perrot   +9 more
wiley   +1 more source

Discovering heterogeneous subpopulations for fine-grained analysis of opioid use and opioid use disorders [PDF]

arXiv, 2018
The opioid epidemic in the United States claims over 40,000 lives per year, and it is estimated that well over two million Americans have an opioid use disorder. Over-prescription and misuse of prescription opioids play an important role in the epidemic.
arxiv  

DNA methylation at the mu-1 opioid receptor gene (OPRM1) promoter predicts preoperative, acute, and chronic postsurgical pain after spine fusion. [PDF]

, 2017
INTRODUCTION:The perioperative pain experience shows great interindividual variability and is difficult to predict. The mu-1 opioid receptor gene (OPRM1) is known to play an important role in opioid-pain pathways.
Chidambaran, Vidya, Ding, Lili, Geisler, Kristie, Ji, Hong, Martin, Lisa J, Sadhasivam, Senthilkumar, Stubbeman, Bobbie L, Weirauch, Matthew T, Zhang, Xue   +8 more
core   +1 more source

Cebranopadol: A Novel Potent Analgesic Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist

Journal of Pharmacology and Experimental Therapeutics, 2014
Cebranopadol (trans-6′-fluoro-4′,9′-dihydro-N,N-dimethyl-4-phenyl-spiro[cyclohexane-1,1′(3′H)-pyrano[3,4-b]indol]-4-amine) is a novel analgesic nociceptin/orphanin FQ peptide (NOP) and opioid receptor agonist [Ki (nM)/EC50 (nM)/relative efficacy ...
K. Linz, T. Christoph, T. Tzschentke, T. Koch, K. Schiene, M. Gautrois, W. Schröder, B. Kögel, H. Beier, W. Englberger, S. Schunk, J. de Vry, U. Jahnel, S. Frosch   +13 more
semanticscholar   +1 more source

Acute cardiovascular effects associated with the use of prescription medications: A Danish nationwide screening study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim This study aims to conduct a hypothesis‐generating screening for acute cardiovascular effects of prescription medications. Methods This Danish nationwide screening study was conducted among incident cases of cardiovascular diseases, including myocardial infarction (MI), ischemic stroke (IS), heart failure (HF), venous thromboembolism (VTE),
Saad Hanif Abbasi, Lars Christian Lund, Jesper Hallas, Martin Thomsen Ernst, Anton Pottegård   +4 more
wiley   +1 more source

Variation in the infant health effects of the women, infants, and children program by predicted risk using novel machine learning methods

Health Economics, Volume 32, Issue 1, Page 194-217, January 2023., 2023
Abstract The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) has an extensive literature documenting positive effects on infant health outcomes, specifically preterm birth, low birthweight, small size for gestational age, and infant mortality.
Evan D. Peet, Dana Schultz, Susan Lovejoy, Fuchiang (Rich) Tsui   +3 more
wiley   +1 more source

Endogenous opioids regulate moment-to-moment neuronal communication and excitability

Nature Communications, 2017
The endogenous opioid system regulates fear and anxiety, but the underlying cellular mechanism is unclear. Winterset al. shows that in the intercalated cells (ITC) of the amygdala, endogenous opioids suppress glutamatergic inputs via the δ-opioid ...
Bryony L. Winters, Gabrielle C. Gregoriou, Sarah A. Kissiwaa, Oliver A. Wells, Danashi I. Medagoda, Sam M. Hermes, Neil T. Burford, Andrew Alt, Sue A. Aicher, Elena E. Bagley   +9 more
doaj   +1 more source

Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia.

Journal of Clinical Investigation, 2014
The development of opioid-induced analgesic tolerance and hyperalgesia is a clinical challenge for managing chronic pain. Adaptive changes in protein translation in the nervous system are thought to promote opioid tolerance and hyperalgesia; however, how
Ji-Tian Xu, Jian-Yuan Zhao, Xiuli Zhao, Davinna L. Ligons, V. Tiwari, Fidelis E. Atianjoh, Chun-Yi Lee, Lingli Liang, Weidong Zang, D. Njoku, S. Raja, M. Yaster, Y. Tao   +12 more
semanticscholar   +1 more source

Trends in gabapentinoid prescribing: A nationwide Danish drug utilization study

British Journal of Clinical Pharmacology, EarlyView.
Aims Pregabalin and gabapentin are increasingly used for pain and other conditions. Concerns exist about overuse as well as potential misuse and abuse. To guide rational prescribing practices, we provide detailed nationwide data on the use of gabapentinoids in Denmark.
Anton Pottegård, Lotte Rasmussen, Morten Olesen, Anne Mette Skov Sørensen, Zandra Nymand Ennis, Joseph Kane, Sarah Baxter, Blánaid Hicks   +7 more
wiley   +1 more source