Results 51 to 60 of about 2,508,905 (426)
Small-molecule nociceptin receptor agonist ameliorates mast cell activation and pain in sickle mice
Haematologica, 2015 Treatment of pain with morphine and its congeners in sickle cell anemia is suboptimal, warranting the need for analgesics devoid of side effects, addiction and tolerance liability. Small-molecule nociceptin opioid receptor ligands show analgesic efficacy
Derek Vang +7 more
doaj +1 more source
Cell death sensitization of leukemia cells by opioid receptor activation [PDF]
, 2013 Cyclic AMP (cAMP) regulates a number of cellular processes and modulates cell death induction. cAMP levels are altered upon stimulation of specific G-protein-coupled receptors inhibiting or activating adenylyl cyclases.
Alt, A. +7 more
core +2 more sources
Science Signaling, 2018 High-efficacy opioids enhance receptor desensitization due to rapid and sustained GRK2/β-arrestin interactions. Controlling opioid receptor desensitization Chronic opioid use leads to tolerance and the need for increasing doses to achieve pain relief ...
E. Miess +13 more
semanticscholar +1 more source
Life, 2021 Cross-talk between opioid and adrenergic receptors is well-characterized and involves second messenger systems, the formation of receptor heterodimers, and the presence of extracellular allosteric binding regions for the complementary ligand; however ...
Robert Root-Bernstein, Beth Churchill
doaj +1 more source
Rubsicolins are naturally occurring G-protein-biased delta opioid receptor peptides
bioRxiv, 2018 The impact that β-arrestin proteins have on G-protein-coupled receptor trafficking, signaling and physiological behavior has gained much appreciation over the past decade.
Robert J. Cassell +6 more
semanticscholar +1 more source
Pharmacology Research & Perspectives, 2022 Morphine is frequently applied in cancer patients for pain management. However, its effects on cancer are not well understood but observed to be specific to certain cancer types. We previously revealed the stimulatory properties of morphine in esophageal
Zhengwen Yu +3 more
doaj +1 more source
Structural insights into μ-opioid receptor activation
Nature, 2015 Activation of the μ-opioid receptor (μOR) is responsible for the efficacy of the most effective analgesics. To shed light on the structural basis for μOR activation, here we report a 2.1 Å X-ray crystal structure of the murine μOR bound to the morphinan ...
Weijiao Huang +17 more
semanticscholar +1 more source
Machine-learning Repurposing of DrugBank Compounds for Opioid Use Disorder [PDF]
arXiv, 2023 Opioid use disorder (OUD) is a chronic and relapsing condition that involves the continued and compulsive use of opioids despite harmful consequences. The development of medications with improved efficacy and safety profiles for OUD treatment is urgently needed.
arxiv
Chronic morphine treatment attenuates cell growth of human BT474 breast cancer cells by rearrangement of the ErbB signalling network. [PDF]
, 2013 There is increasing evidence that opioid analgesics may interfere with tumour growth. It is currently thought that these effects are mediated by transactivation of receptor tyrosine kinase (RTK)-controlled ERK1/2 and Akt signalling.
Ammer, Hermann +2 more
core +2 more sources
μ opioid receptor, social behaviour and autism spectrum disorder: reward matters
British Journal of Pharmacology, 2018 The endogenous opioid system is well known to relieve pain and underpin the rewarding properties of most drugs of abuse. Among opioid receptors, the μ receptor mediates most of the analgesic and rewarding properties of opioids.
L. Pellissier +4 more
semanticscholar +1 more source