Multi-objective Molecular Optimization for Opioid Use Disorder Treatment Using Generative Network Complex [PDF]
arXiv, 2023 Opioid Use Disorder (OUD) has emerged as a significant global public health issue, with complex multifaceted conditions. Due to the lack of effective treatment options for various conditions, there is a pressing need for the discovery of new medications. In this study, we propose a deep generative model that combines a stochastic differential equation (
arxiv
Opioid-induced mitogen-activated protein kinase signaling in rat enteric neurons following chronic morphine treatment. [PDF]
PLoS ONE, 2014 Opioids, acting at μ opioid receptors, are commonly used for pain management. Chronic opioid treatment induces cellular adaptations, which trigger long-term side effects, including constipation mediated by enteric neurons.
Celine Duraffourd +4 more
doaj +1 more source
Specific down-regulation of spinal μ-opioid receptor and reduced analgesic effects of morphine in mice with postherpetic pain [PDF]
, 2006 The analgesic effects of opioid agonists and the expression of μ-and κ-opioid receptors were compared between mice with herpetic pain and those with postherpetic pain induced by herpetic virus inoculation.
Kuraishi Yasushi +3 more
core +2 more sources
Science Translational Medicine, 2018 The small-molecule AT-121 is an agonist of nociceptin and mu opioid peptide receptors and mediates analgesia without opioid-associated side effects in nonhuman primates.
H. Ding +9 more
semanticscholar +1 more source
Estradiol and Mu opioid-mediated reward: The role of estrogen receptors in opioid use
Addiction Neuroscience, 2023 Opioid use and opioid use disorder are characterized by sex and gender differences, and some of these differences may be mediated by differences in the hormonal milieu within and across individuals.
Sarah B. Ethridge, Mark A. Smith
doaj
Molecular Perspectives for mu/delta Opioid Receptor Heteromers as Distinct, Functional Receptors
Cells, 2014 Opioid receptors are the sites of action for morphine and the other opioid drugs. Abundant evidence now demonstrates that different opioid receptor types can physically associate to form heteromers.
Edmund W. Ong, Catherine M. Cahill
doaj +1 more source
Molecules, 2020 Achieving effective pain management is one of the major challenges associated with modern day medicine. Opioids, such as morphine, have been the reference treatment for moderate to severe acute pain not excluding chronic pain modalities.
Abdelfattah Faouzi +2 more
doaj +1 more source
Morphine activates neuroinflammation in a manner parallel to endotoxin [PDF]
, 2012 Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors.
A. A. Somogyi +42 more
core +2 more sources
Chronic neuropathic pain reduces opioid receptor availability with associated anhedonia in rat
Pain, 2018 The opioid system plays a critical role in both the experience and management of pain. Although acute activation of the opioid system can lead to pain relief, the effects of chronic pain on the opioid system remain opaque.
S. Thompson +8 more
semanticscholar +1 more source
Pharmacological Profiles of Oligomerized μ-Opioid Receptors
Cells, 2013 Opioids are widely prescribed pain relievers with multiple side effects and potential complications. They produce analgesia via G-protein-protein coupled receptors: μ-, δ-, κ-opioid and opioid receptor-like 1 receptors.
Ing-Kang Ho, Cynthia Wei-Sheng Lee
doaj +1 more source