Results 131 to 140 of about 2,447,948 (384)
Trends in gabapentinoid prescribing: A nationwide Danish drug utilization study
British Journal of Clinical Pharmacology, EarlyView.Aims Pregabalin and gabapentin are increasingly used for pain and other conditions. Concerns exist about overuse as well as potential misuse and abuse. To guide rational prescribing practices, we provide detailed nationwide data on the use of gabapentinoids in Denmark.
Anton Pottegård +7 more
wiley +1 more source
A functional approach to deconvolve dynamic neuroimaging data [PDF]
arXiv, 2014 Positron Emission Tomography (PET) is an imaging technique which can be used to investigate chemical changes in human biological processes such as cancer development or neurochemical reactions. Most dynamic PET scans are currently analyzed based on the assumption that linear first order kinetics can be used to adequately describe the system under ...
arxiv
Science Signaling, 2011 Partial and full agonists of opioid receptors produce distinct responses by enriching distinct populations of phosphorylated receptors. Decoding the Response to Morphine Although the drug morphine shares with the endogenous opioid peptide enkephalin the ...
E. Lau +6 more
semanticscholar +1 more source
EudraVigilance insights: Suspected adverse drug reactions in infants through breastfeeding
British Journal of Clinical Pharmacology, EarlyView.Aims We aimed to describe suspected adverse drug reactions (ADRs) in infants resulting from medications transmitted through mothers' milk, as reported to the European ADR database, EudraVigilance. The research sought to understand the frequency, seriousness and nature of these ADRs to assess potential risks associated with maternal medication use ...
Ida M. Heerfordt +7 more
wiley +1 more source
Insights into the interaction between hemorphins and δ-opioid receptor from molecular modeling
Frontiers in Molecular BiosciencesHemorphins are short atypical opioid peptide fragments embedded in the β-chain of hemoglobin. They have received considerable attention recently due to their interaction with opioid receptors.
Priya Antony +4 more
doaj +1 more source
Frontiers in Pediatrics, 2018 The endogenous opioid system, comprised of multiple opioid neuropeptide and receptor gene families, is highly expressed by developing neural cells and can significantly influence neuronal and glial maturation. In many central nervous system (CNS) regions,
Kurt F. Hauser +5 more
doaj +1 more source
A Knowledge Graph-based Approach for Exploring the U.S. Opioid Epidemic [PDF]
arXiv, 2019 The United States is in the midst of an opioid epidemic with recent estimates indicating that more than 130 people die every day due to drug overdose. The over-prescription and addiction to opioid painkillers, heroin, and synthetic opioids, has led to a public health crisis and created a huge social and economic burden.
arxiv
Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application
BMEMat, EarlyView.The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah +9 more
wiley +1 more source
Differential ontogeny of multiple opioid receptors (mu, delta, and kappa) [PDF]
, 1985 J W Spain, BL Roth, CJ Coscia
openalex +1 more source
Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source