Results 151 to 160 of about 2,447,948 (384)
Opioids increase potassium conductance in submucous neurones of guinea‐pig caecum by activating δ‐receptors [PDF]
, 1986 S. Mihara, R. Alan North
openalex +1 more source
Nonconventional Techniques in Plant Alkaloid Extraction: A Decade of Progress (2014–2023)
Chemistry &Biodiversity, EarlyView.This figure seeks to represent the evolution of the different unconventional approaches that were adopted for the extraction of plant‐derived alkaloids during the decade from 2014 to 2023. ABSTRACT Plant metabolism encompasses primary and secondary pathways, with secondary metabolism yielding diverse natural products crucial for plant adaptation and ...
Victor Menezes Sipoloni +5 more
wiley +1 more source
Speaking of Stigma: Piloting Language Training in Addiction Counseling Coursework
Counselor Education and Supervision, EarlyView.ABSTRACT This pilot study examined counselor‐in‐training (CIT) attitudes and awareness regarding stigma and stigmatizing language aimed at those with substance use disorders before and after an author‐developed educational intervention. Results indicated this intervention positively impacted CIT awareness and attitudes and their ability to identify and
Amy L. Grybush +2 more
wiley +1 more source
Large-scale Analysis of Opioid Poisoning Related Hospital Visits in New York State [PDF]
AMIA Annu Symp Proc. 2018;2017:545-554, 2017 Opioid related deaths are increasing dramatically in recent years, and opioid epidemic is worsening in the United States. Combating opioid epidemic becomes a high priority for both the U.S. government and local governments such as New York State. Analyzing patient level opioid related hospital visits provides a data driven approach to discover both ...
arxiv
ChemMedChem, EarlyView.The review focuses on relationships of oxadiazole derivative structures and their antimycobacterial activity including target structures in mycobacteria, in vitro or in vivo pharmacokinetic parameters, and toxicity. Apart from direct antimycobacterial activity, some 1,2,4‐oxadiazole derivatives can potentiate the antimycobacterial effect of ethionamide
Marta Kučerová‐Chlupáčová
wiley +1 more source
Detection of Opioid Users from Reddit Posts via an Attention-based Bidirectional Recurrent Neural Network [PDF]
The opioid epidemic, referring to the growing hospitalizations and deaths because of overdose of opioid usage and addiction, has become a severe health problem in the United States. Many strategies have been developed by the federal and local governments and health communities to combat this crisis.
arxiv +1 more source
Design and Synthesis of Tetrahydropyrrolo[3,4‐c]Pyrazole Sigma‐1 Receptor Ligands
ChemMedChem, EarlyView.This study highlights the tetrahydropyrrolo[3,4‐c]pyrazole scaffold as a promising platform for S1R ligands development. Key findings include compound 19’s high S1R affinity (Ki=75 nM), influenced by strategic nitrogen substitutions and reduced steric hindrance.
Giuseppe Cosentino +7 more
wiley +1 more source
ChemMedChem, Accepted Article.The work presented herein outlines the ongoing structure‐activity relationship (SAR) studies centered around a potent, efficacious, and selective activators of the GIRK1/2 channel. Optimization studies centered around the pyrazole privileged scaffold, the N‐1‐position of the pyrazole and the right‐hand ether.
Sumaiya Nahid +8 more
wiley +1 more source
ChemPlusChem, Accepted Article.Adapting high‐throughput (HT) synthetic methods to the modification of drugs and to testing of their bioactivity should expedite drug discovery. Here, we demonstrate the applicability of HT desorption electrospray ionization mass spectrometry (DESI MS) to achieve late‐stage functionalization (LSF) and so to rapidly generate a modified opioid library ...
R Graham Cooks +3 more
wiley +1 more source
Journal of Counseling &Development, Volume 101, Issue 1, Page 15-28, January 2023., 2023 Abstract Although advocacy is a priority for counseling professionals, little is known about counseling advocates’ participation in the legislative advocacy process. Recent legislation to address the opioid crisis allowed counseling advocates to provide public comments to advance counselor inclusion in the Medicare program.
Jordan B. Westcott +2 more
wiley +1 more source