Results 171 to 180 of about 2,447,948 (384)

Identifying Spatiotemporal Patterns in Opioid Vulnerability: Investigating the Links Between Disability, Prescription Opioids and Opioid-Related Mortality [PDF]

arXiv
The opioid crisis remains one of the most daunting and complex public health problems in the United States. This study investigates the national epidemic by analyzing vulnerability profiles of three key factors: opioid-related mortality rates, opioid prescription dispensing rates, and disability rank ordered rates. This study utilizes county level data,
arxiv  

Waxy‐ or Putty‐Like Materials as a Novel Drug Preparation for Synthetic Cannabinoid Receptor Agonists: Detection in Prisons and In Vitro Cannabinoid Receptor Activity

Drug Testing and Analysis, EarlyView.
Waxy‐ or putty‐like materials has emerged as a novel drug preparation for synthetic cannabinoids and other drugs in UK prisons. An in vitro CB1 bioassay was used to evaluate the CB1 activating potential of MDMB‐INACA and extracts from eight seized samples. MDMB‐INACA had moderate efficacy but low potency at CB1.
Axelle Timmerman, Marie H. Deventer, Rachael Andrews, Robert Reid, Victoria Marland, Darren Edwards, Christopher R. Pudney, Niamh Nic Daéid, Christophe P. Stove, Caitlyn Norman   +9 more
wiley   +1 more source

Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo‐Pyridyl Synthetic Cannabinoid Receptor Agonist CH‐FUBBMPDORA

Drug Testing and Analysis, EarlyView.
Another Chinese generic ban‐evading SCRA, CH‐FUBBMPDORA, has emerged. This study reports its first identification in Europe, its analytical characterization (NMR, Raman, FTIR, GC–MS, and HRMS), its cannabinoid activation potential in a βarr2 recruitment assay, and its metabolization profile.
Marie H. Deventer, Maria Carmela Emanuele, Brianna N. Stang, Katleen Van Uytfanghe, Jessica Masson, Xavier Bouvot, Catherine Lamoureux, Alessandro Proposito, Fabiano Reniero, Margaret V. Holland, Alex J. Krotulski, Luisa Mannina, Christophe P. Stove, Claude Guillou   +13 more
wiley   +1 more source

The Downregulation of Opioid Receptors and Neuropathic Pain. [PDF]

Int J Mol Sci, 2023
Li L, Chen J, Li YQ.
europepmc   +1 more source

Screening and Quantification of the Synthetic Cannabinoid Receptor Agonist 5F‐MDMB‐PINACA From Seized Prison Paper Using Ultraperformance Liquid Chromatography–Mass Spectrometry Approaches

Drug Testing and Analysis, EarlyView.
Synthetic cannabinoid receptor agonists are being infused on paper and illicitly introduced into prisons through mail correspondence. An approach to quantify and map the synthetic cannabinoid 5F‐ADB on a seized paper sample from a UK prison was determined using ultraperformance liquid chromatography–quadrupole Dalton–mass spectrometry.
Giorgia Vaccaro, Jacqueline L. Stair, Stewart B. Kirton, Daniel Baker, Amira Guirguis   +4 more
wiley   +1 more source

Targeting Opioid Receptors in Addiction and Drug Withdrawal: Where Are We Going? [PDF]

Int J Mol Sci, 2023
Tabanelli R, Brogi S, Calderone V.
europepmc   +1 more source

Effects of Dimenhydrinate on Motor Behavior and Vascular Function: Possible Implications for the Field of Sports

Drug Testing and Analysis, EarlyView.
Regarding cardiovascular effects, DMH decreased vascular reactivity to phenylephrine and acetylcholine. We observed that the combination of DPH and 8‐Cl‐T was identified as the responsible for increasing blood pressure and heart rate in the biological model used.
Jazmín Flores‐Monroy, Diana Ramírez‐Hernández, Diego Lezama‐Martínez, Benjamín Velasco‐Bejarano   +3 more
wiley   +1 more source

Correction: Kappa opioid receptors as modulators of novelty processing. [PDF]

Neuropsychopharmacology, 2023
Braden K, Castro DC.
europepmc   +1 more source

Cross‐Cultural Validation of the Binge Eating Disorder Screener‐7 (BEDS‐7) Across 42 Countries

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective This study aimed to evaluate the reliability and validity of the Binge Eating Disorder Screener‐7 (BEDS‐7) across 42 countries and 26 languages, assessing its reliability and validity as a screening tool for binge‐eating disorder (BED) in diverse cultural contexts.
Ateret Gewirtz‐Meydan, Zohar Spivak‐Lavi, Shane W. Kraus, Léna Nagy, Mónika Koós, Zsolt Demetrovics, Marc N. Potenza, Rafael Ballester‐Arnal, Dominik Batthyány, Sophie Bergeron, Joël Billieux, Peer Briken, Julius Burkauskas, Georgina Cárdenas‐López, Joana Carvalho, Jesús Castro‐Calvo, Lijun Chen, Giacomo Ciocca, Ornella Corazza, Rita I. Csako, David P. Fernandez, Elaine F. Fernandez, Hironobu Fujiwara, Johannes Fuss, Roman Gabrhelík, Biljana Gjoneska, Mateusz Gola, Joshua B. Grubbs, Hashim T. Hashim, Md. Saiful Islam, Mustafa Ismail, Martha C. Jiménez‐Martínez, Tanja Jurin, Ondrej Kalina, Verena Klein, András Költő, Chih‐Ting Lee, Sang‐Kyu Lee, Karol Lewczuk, Chung‐Ying Lin, Christine Lochner, Silvia López‐Alvarado, Kateřina Lukavská, Percy Mayta‐Tristán, Dan J. Miller, Oľga Orosová, Gábor Orosz, Sungkyunkwan University's Research Team, Hyein Chang, Kyeongwoo Park, Fernando P. Ponce, Gonzalo R. Quintana, Gabriel C. Quintero Garzola, Jano Ramos‐Diaz, Kévin Rigaud, Ann Rousseau, Marco De Tubino Scanavino, Marion K. Schulmeyer, Pratap Sharan, Mami Shibata, Sheikh Shoib, Vera Sigre‐Leirós, Luke Sniewski, Ognen Spasovski, Vesta Steibliene, Dan J. Stein, Julian Strizek, Berk C. Ünsal, Marie‐Pier Vaillancourt‐Morel, Marie Claire Van Hout, Beáta Bőthe   +70 more
wiley   +1 more source

Differential interaction patterns of opioid analgesics with µ opioid receptors correlate with ligand-specific voltage sensitivity. [PDF]

Elife, 2023
Kirchhofer SB, Lim VJY, Ernst S, Karsai N, Ruland JG, Canals M, Kolb P, Bünemann M.   +7 more
europepmc   +1 more source