Results 211 to 220 of about 72,097 (314)

Delta opioid receptors engage multiple signaling cascades to differentially modulate prefrontal GABA release with input and target specificity. [PDF]

Cell Rep
Alexander RPD, Bender KJ.
europepmc   +1 more source

Agonists and antagonists bind to different domains of the cloned kappa opioid receptor.

, 1994
Hyesik Kong, K Raynor, Hideaki Yano, Jun Takeda, Graeme I. Bell, Terry Reisine   +5 more
openalex   +1 more source

Dexmedetomidine as a Ropivacaine Adjuvant in a Thoracic Paravertebral Block Combined With an Erector Spinae Plane Block for Improving Early Quality of Recovery After Transapical Transcatheter Aortic Valve Implantation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The study aimed to investigate the effectiveness of dexmedetomidine (Dex) as an adjuvant for ropivacaine in a thoracic paravertebral block (TPVB) combined with an erector spinae plane block (ESPB) for improving early quality of recovery and postoperative pain after transapical transcatheter aortic valve implantation (TAVI).
Gui‐Ling Dong, Rong‐En Qiu, Chen‐Zhan Xu   +2 more
wiley   +1 more source

Cortical kappa opioid receptors integrate negative affect and sleep disturbance. [PDF]

Transl Psychiatry
Lillo Vizin RC, Ito H, Kopruszinski CM, Ikegami M, Ikegami D, Yue X, Navratilova E, Moutal A, Cowen SL, Porreca F.   +9 more
europepmc   +1 more source

Disentangling informing participants from obtaining their consent

Learning Health Systems, EarlyView.
Abstract Introduction Pragmatic clinical trials conducted in the context of routine care frequently satisfy the regulatory criteria for a waiver of research consent. When they do, investigators and Institutional Review Boards might assume that there is no reason to communicate any information regarding the study to participants.
Patricia Pearl O'Rourke, Joseph Ali, Judith Carrithers, David Magnus, Benjamin S. Wilfond, Sheana Bull, Laura M. Dember, Gail D'Onofrio, Julie Goldman, P. Michael Ho, Edward R. Melnick, Karen L. Staman, James A. Tulsky, Miguel A. Vazquez, Angelo Volandes, David Wendler   +15 more
wiley   +1 more source

Opioid receptors: single molecule studies shed light on mechanisms of efficacy. [PDF]

Signal Transduct Target Ther
Krasel C, Bünemann M.
europepmc   +1 more source

Complementarity of ? opioid ligand pharmacophore and receptor models [PDF]

, 1999
Henry I. Mosberg
openalex   +1 more source

A framework for health systems to assess and prioritize participation in pragmatic clinical trials

Learning Health Systems, EarlyView.
Abstract Introduction Pragmatic clinical trials (PCTs) are frequently embedded within settings in which patients receive their routine clinical care. The health care institutions that deliver routine clinical care must therefore decide how they prioritize PCTs in comparison to other institutional priorities. Yet no formal guidance yet exists to support
Stephanie R. Morain, Matthew W. Semler, Jonathan D. Casey   +2 more
wiley   +1 more source

Xylazine as an emerging new psychoactive substance; focuses on both 5-HT₇ and κ-opioid receptors' molecular interactions and isosteric replacement. [PDF]

Arch Pharm (Weinheim)
Floresta G, Granzotto A, Patamia V, Arillotta D, Papanti GD, Guirguis A, Corkery JM, Martinotti G, Sensi SL, Schifano F.   +9 more
europepmc   +1 more source

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, EarlyView.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source