Results 61 to 70 of about 2,447,948 (384)
Regulation of µ-Opioid Receptors: Desensitization, Phosphorylation, Internalization, and Tolerance
Pharmacological Reviews, 2013 Morphine and related µ-opioid receptor (MOR) agonists remain among the most effective drugs known for acute relief of severe pain. A major problem in treating painful conditions is that tolerance limits the long-term utility of opioid agonists ...
John T. Williams +8 more
semanticscholar +1 more source
Frontiers in Physiology, 2023 Opioid medications are the mainstay of pain management but present substantial side-effects such as respiratory depression which can be lethal with overdose.
Jamil Danaf +3 more
doaj +1 more source
Molecular Physiology of Enteric Opioid Receptors
The American Journal of Gastroenterology Supplements, 2014 Opioid drugs have powerful antidiarrheal effects and many patients taking these drugs for chronic pain relief experience chronic constipation that can progress to opioid-induced bowel dysfunction.
J. Galligan, H. Akbarali
semanticscholar +1 more source
Arthritis Care &Research, Accepted Article.As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Co‐morbid depression is prevalent in adults with IA, affecting 15 to 39% of people. Whilst pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox +3 more
wiley +1 more source
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials, EarlyView.Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
wiley +1 more source
Journal of Experimental & Clinical Cancer Research, 2009 Background opioid and somatostatin receptors (SSTRs) that can assemble as heterodimer were individually reported to modulate malignant cell proliferation and to favour apoptosis.
Allouche Stéphane +4 more
doaj +1 more source
Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice. [PDF]
PLoS ONE, 2014 Neuropeptide FF (NPFF) is known to be an endogenous opioid-modulating peptide. Nevertheless, very few researches focused on the interaction between NPFF and endogenous opioid peptides. In the present study, we have investigated the effects of NPFF system
Zi-long Wang +10 more
doaj +1 more source
Opioid and cannabinoid receptors
Current Opinion in Neurobiology, 1994 Opioids and cannabinoids are two major classes of drugs with important clinical uses as well as significant side effects. Recently, the three major subtypes of opioid receptors, delta, kappa and mu, have been cloned. Both the endogenous cannabinoids and their receptors have also recently been cloned.
Terry Reisine, Michael J. Brownstein
openaire +3 more sources
Binding Pathway of Opiates to $μ$ Opioid Receptors Revealed by Unsupervised Machine Learning [PDF]
, 2018 Many important analgesics relieve pain by binding to the $\mu$-Opioid Receptor ($\mu$OR), which makes the $\mu$OR among the most clinically relevant proteins of the G Protein Coupled Receptor (GPCR) family. Despite previous studies on the activation pathways of the GPCRs, the mechanism of opiate binding and the selectivity of $\mu$OR are largely ...
arxiv +1 more source
Frontiers in Pharmacology, 2014 Opioids selective for the G protein-coupled mu opioid receptor (MOR) produce potent analgesia and euphoria. Heroin, a synthetic opioid, is considered one of the most addictive substances, and the recent exponential rise in opioid addiction and overdose ...
E. Chartoff, H. Connery
semanticscholar +1 more source