Results 61 to 70 of about 130,157 (357)

Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice. [PDF]

PLoS ONE, 2014
Neuropeptide FF (NPFF) is known to be an endogenous opioid-modulating peptide. Nevertheless, very few researches focused on the interaction between NPFF and endogenous opioid peptides. In the present study, we have investigated the effects of NPFF system
Zi-long Wang, Quan Fang, Zheng-lan Han, Jia-xin Pan, Xu-hui Li, Ning Li, Hong-hai Tang, Pei Wang, Ting Zheng, Xue-mei Chang, Rui Wang   +10 more
doaj   +1 more source

Physician Referral Patterns to Physical Therapists for Managing Knee Osteoarthritis: A Retrospective Analysis of Electronic Health Records from an Integrated Health System

Arthritis Care &Research, Accepted Article.
Objectives This study aims to describe the frequency and timing of physician referrals to physical therapists (PT) and other treatments prescribed over 12 months in patients with recent onset of knee osteoarthritis (KOA). The study also aims to identify determinants of early PT referrals.
Samannaaz S. Khoja, Joel M. Stevans, Gustavo J. Almeida, Clair Smith, Janet K. Freburger   +4 more
wiley   +1 more source

The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components [PDF]

, 2014
G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner.
Agnati, Luigi F, Borroto-Escuela, Dasiel O, Brito, Ismel, Di Palma, Michael, Duchou, Jolien, Fuxe, Kjell, Guidolin, Diego, Oflijan, Julia, Rivera, Alicia, Romero-Fernandez, Wilber, Skieterska, Kamila, Suárez-Boomgaard, Diana, Van Craenenbroeck, Kathleen   +12 more
core   +4 more sources

Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry

eLife, 2019
Identifying neurons that have functional opioid receptors is fundamental for the understanding of the cellular, synaptic and systems actions of opioids. Current techniques are limited to post hoc analyses of fixed tissues. Here we developed a fluorescent
Seksiri Arttamangkul, Andrew Plazek, Emily J Platt, Haihong Jin, Thomas F Murray, William T Birdsong, Kenner C Rice, David L Farrens, John T Williams   +8 more
doaj   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Battery‐Free Dual‐Channel Wireless Neurostimulator Using Passive Circuitry for Neuropathic Pain Modulation

Advanced Healthcare Materials, EarlyView.
A compact, wireless neural stimulator featuring a novel tapping inductor enables selective and independent stimulation of the motor cortex in rats via a single receiver coil. This minimally invasive system effectively reduces neuropathic pain through targeted cortical activation, offering a new avenue for bioelectronic pain therapies and advancing ...
Jeongju Moon, Kyungmo Seong, Hyeon Gyu Kim, Wonki Mun, Seung Hyun Min, Sung‐Yun Park, Joonsoo Jeong, Chin Su Koh, Hyun Ho Jung, Kyungsik Eom   +9 more
wiley   +1 more source

Neuropeptides in the Extracellular Space of the Mouse Cortex Measured In Vivo by Nanodialysis Probe Coupled with LC‐MS

Angewandte Chemie, EarlyView.
This study reveals a complex peptidomic landscape in the mouse somatosensory cortex, identifying locally released and potentially transported neuropeptides using a membrane‐free nanodialysis sampling probe coupled with nanoLC‐timsTOF mass spectrometry.
Keyin Li, Weihua Shi, Yanqi Tan, Yu Ding, Alex G. Armstrong, Yurii Vlasov, Jonathan V. Sweedler   +6 more
wiley   +2 more sources

A Theory of Natural Addiction [PDF]

, 2007
Economic theories of rational addiction aim to describe consumer behavior in the presence of habit-forming goods. We provide a biological foundation for this body of work by formally specifying conditions under which it is optimal to form a habit.
Ainslie, Atkinson, Attila Tasnádi, Baldwin, Baron-Cohen, Becker, Becker, Bergstrom, Blass, Blass, Blass, Bodnar, Booth, Brick, Camerer, Camerer, Campbell, Carson-DeWitt, Chiara, Cohen, Colantuoni, Cooper, Cooper, Cummings, Deth, Drewnowski, Dudley, Dum, Fantino, Fehr, Foster, Gilbertson, Gillberg, Gosnell, Griffiths, Grossman, Gruber, Gul, Harrigan, Headlee, Hirshleifer, Hirshleifer, Holtzman, Jaffe, Kahneman, Kalat, Kavaliers, Kavaliers, Killian, Laibson, Laibson, Leboyer, Leboyer, Loewenstein, Martin, McKim, Mello, Mercer, Morley, Mucha, Mucha, Nelson, Nesse, Nesse, Orphanides, Orphanides, Ostrowski, Parfitt, Pert, Pomerleau, Raiten, Raven, Robson, Rogers, Rudski, Samuelson, Sanger, Savage, Schuckit, Si, Simon, Simpkins, Smith, Sozou, Spanagel, Sullivan, Sullivan, ter Riet, Terenius, Trenton G. Smith, van Ree, van Ree, van Ree, Waeltl, Weeks, Weeks, Weiss, Williams, Yamamoto, Yeomans, Yeomans, Yeomans, Zigmond   +102 more
core   +1 more source

Calcitonin Gene‐Related Peptide (CGRP)‐Expressing Neurons in the External Lateral Parabrachial Area Regulate Pain‐Induced Sleep Disturbances

Advanced Science, EarlyView.
Lynch et al., identified novel targets on the wake‐promoting pathways that can effectively treat pain‐induced sleep disturbances. The authors demonstrated that Calcitonin gene‐related peptide‐expressing neurons (CGRP) in the external lateral parabrachial nucleus (PBelCGRP) serve as the primary relay node for pain stimuli that cause sleep disruption ...
Nicole Lynch, Roberto De Luca, Richard L Spinieli, Enrico Rillosi, Renner C Thomas, Samuel Sailesh, Nishta Gangeddula, Janayna D Lima, Sathyajit S Bandaru, Elda Arrigoni, Agustin Melo‐Carrillo, Rami Burstein, Stephen Thankachan, Satvinder Kaur   +13 more
wiley   +1 more source

Opioid and GABAB receptors differentially couple to an adenylyl cyclase/protein kinase A downstream effector after chronic morphine treatment.

Frontiers in Pharmacology, 2014
Opioids are intensely addictive, and cessation of their chronic use is associated with a highly aversive withdrawal syndrome. A cellular hallmark of withdrawal is an opioid sensitive protein kinase A-dependent increase in GABA transporter-1 (GAT-1 ...
Elena Elizabeth Bagley
doaj   +1 more source