Results 131 to 140 of about 1,408,984 (372)

Cross-Cultural Collaborations for Addressing Opioid Use Disorder in Utah [PDF]

, 2023
Cross-cultural collaboration allows for more effective interventions for opioid use disorder among tribal communities. Practicing cultural humility, incorporating Indigenous knowledge, and amplifying Indigenous voices are crucial to the cross-cultural ...
Chapoose, Michelle Q., Fanning Madden, Erin, Manning, Cassandra, Prevedel, Suzanne M., Sulzer, Sandra H., Warnick, Claire, Zaman, Katie   +6 more
core   +1 more source

A Randomized Phase 1 Study Evaluating Pharmacokinetics, Safety, and Tolerability of a High‐Concentration, Long‐Acting Cabotegravir Formulation in Adults Without HIV

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Long‐acting (LA) cabotegravir 200‐mg/mL (CAB200) injections are approved for HIV‐1 prevention and as a complete LA HIV‐1 treatment regimen with rilpivirine. A high‐concentration suspension formulation, cabotegravir 400 mg/mL (CAB400‐D), was developed to enable less frequent dosing and self‐administration. This phase 1, double‐blind, randomized
Kelong Han, Paul Benn, Jörg Sievers, David Dorey, Michael Warwick‐Sanders, Randa Hareedy, Louise Harkness, Claudia Leemereise, Kjersten Offenbecker, Christina Donatti, Darin B. Brimhall, Christian Schwabe, Craig Boyle, Michael A. Hassman, Steve Knowles, Ronald D'Amico, William R. Spreen   +16 more
wiley   +1 more source

Analysis of the Genetic and Neurological Components of Opioid Addiction, with Public Health Perspectives of the Opioid Epidemic in the United States of America [PDF]

, 2019
Opioid addiction has reached epidemic levels around the world, with over-prescription of opioid pain relievers being an often-cited reason for the epidemic in the USA. This project looks at opioid addiction from three perspectives: a review of literature
Dubhashi, Janhavi A
core   +1 more source

Treatment of Inpatient Opioid Withdrawal with Short-Acting Full Agonist Opioids at a Safety-Net Hospital [PDF]

Fentanyl use leads to increased opioid tolerance in people with opioid use disorder, complicating management of opioid withdrawal syndrome. While accepted as gold standard, methadone and buprenorphine may be insufficient to treat acute opioid withdrawal.
Crouch, Pierre, Logan, Alexander, Martin, Marlene, Nguyen, Oanh K, Skinner, Sasha, Slown, Kristin, Steiner, Gabriela, Suen, Leslie W   +7 more
core   +1 more source

Uncovering New Therapeutic Targets for Amyotrophic Lateral Sclerosis and Neurological Diseases Using Real‐World Data

Clinical Pharmacology &Therapeutics, EarlyView.
Although attractive for relevance to real‐world scenarios, real‐world data (RWD) is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in neurological diseases such as the rare disease, amyotrophic lateral sclerosis (ALS), which has no disease‐modifying treatments ...
Mohammadali Alidoost, Jeremy Y. Huang, Georgia Dermentzaki, Anna S. Blazier, Giorgio Gaglia, Timothy R. Hammond, Francesca Frau, Mary Clare McCorry, Dimitry Ofengeim, Jennifer L. Wilson   +9 more
wiley   +1 more source

Low-dose overlap initiation with split tablets of buprenorphine in intubated intensive care unit patients with opioid use disorder

Harm Reduction Journal
Background As the opioid public health crisis evolves to include fentanyl and other potent synthetic opioids, more patients are admitted to the hospital with serious complications of drug use and frequently require higher levels of care, including ...
Laura Szczesniak, Sarah Britton, Theresa Baxter RN, Ross Sullivan   +3 more
doaj   +1 more source

The Criminal Justice Response to the Opioid Crisis in East Baton Rouge Parish [PDF]

, 2020
This report describes: 1) the history and current state of the opioid crisis in East Baton Rouge Parish; 2) the current and planned efforts of the Innovative Prosecution Solutions for Combating Violent Crime and Illegal Opioids (IPS) grant to respond to ...
Little, Kristina, Reling, Timothy T, Rhodes, Judith F, Richardson, Gabriele, Winchester, Elizabeth   +4 more
core   +1 more source

Incident and long-term opioid therapy among patients with psychiatric conditions and medications: a national study of commercial health care claims [PDF]

, 2017
There is growing evidence that opioid prescribing in the United States follows a pattern in which patients who are at the highest risk of adverse outcomes from opioids are more likely to receive long-term opioid therapy.
Bair, Matthew J., Chang, Zheng, D’Onofrio, Brian M., Gibbons, Robert D., Hur, Kwan, Krebs, Erin E., Kroenke, Kurt, Quinn, Patrick D., Rickert, Martin E., Scott, Eric L.   +9 more
core   +1 more source

Aerobic Exercise: An Adjunctive Therapy for Buprenorphine/Naloxone Retention in Opioid Use Disorder [PDF]

, 2020
Opioid agonist treatment has been shown to reduce mortality, comorbid infections, and opioid cravings in patients with opioid use disorder. However, patient long-term retention on opioid agonist treatment is low and hindered by neurobiological and ...
Fong, Timothy
core   +1 more source

Effects of Dimenhydrinate on Motor Behavior and Vascular Function: Possible Implications for the Field of Sports

Drug Testing and Analysis, EarlyView.
Regarding cardiovascular effects, DMH decreased vascular reactivity to phenylephrine and acetylcholine. We observed that the combination of DPH and 8‐Cl‐T was identified as the responsible for increasing blood pressure and heart rate in the biological model used.
Jazmín Flores‐Monroy, Diana Ramírez‐Hernández, Diego Lezama‐Martínez, Benjamín Velasco‐Bejarano   +3 more
wiley   +1 more source