Results 101 to 110 of about 45,788 (261)

Beyond abstinence: Redefining success in cannabis use disorder treatment

Addiction, EarlyView.
Abstract Background Over two decades of pharmacotherapy research has yet to yield a consistently effective medication for cannabis use disorder (CUD), in part because clinical trials have frequently prioritized abstinence as a primary or key endpoint.
Tobias B. Atkin, Frances R. Levin, John Mariani, Christina A. Brezing   +3 more
wiley   +1 more source

Reducing opioid use for chronic pain with a group‐based intervention: Economic evaluation using randomised controlled trial data

Addiction, EarlyView.
Abstract Background and aims Long‐term strong opioid use for chronic non‐malignant pain (CNMP) represents a significant public health challenge, associated with reduced health‐related quality of life (HRQoL) and increased mortality. The Improving the Wellbeing of people with Opioid Treated CHronic pain (I‐WOTCH) trial demonstrated that a multicomponent
Sheeja Manchira Krishnan, Vijay S. Gc, Tom Bromilow, Joe W. E. Moss, Katie Booth, Harbinder K. Sandhu, Andrea Manca, Cynthia Paola Iglesias Urrutia, on behalf of the I‐WOTCH team, Harbinder Kaur Sandhu, Sam Eldabe, Charles Abraham, Sharisse Alleyne, Shyam Balasubramanian, Lauren Betteley, Katie Booth, Dawn Carnes, Andrea Dompieri Furlan, Sam Eldabe, Kirstie Haywood, Maddy Hill, Ranjit Lall, Andrea Manca, Dipesh Mistry, Vivien Patricia Nichols, Jennifer Noyes, Anisur Rahman, Kate Seers, Jane Shaw, Nicole Kit Yee Tang, Stephanie Taylor, Colin Tysall, Martin Underwood, Emma Withers, Cynthia Paola Iglesias Urrutia   +34 more
wiley   +1 more source

Spontaneous oxycodone withdrawal disrupts sleep, diurnal, and electrophysiological dynamics in rats.

PLoS ONE
Opioid dependence is defined by an aversive withdrawal syndrome upon drug cessation that can motivate continued drug-taking, development of opioid use disorder, and precipitate relapse.
Michael Gulledge, William A Carlezon, R Kathryn McHugh, Elizabeth A Kinard, Michael J Prerau, Elena H Chartoff   +5 more
doaj   +1 more source

Cannabis use disorder in patients prescribed medical cannabis—Should we consider prescription cannabis use disorder as a new diagnostic condition?

Addiction, EarlyView.
Abstract Background and Aims The introduction of prescribed medical cannabis in many parts of the world raises issues regarding how we conceptualise Cannabis Use Disorders (CUD). The Diagnostic Statistical Manual Version 5 (DSM5) provides a framework for ‘Prescription Cannabis Use Disorder’ (Pr‐CUD) when a person is using medical cannabis only‐as ...
Nicholas Lintzeris, Llewellyn Mills
wiley   +1 more source

Low dose lofexidine for medically directed outpatient opioid tapering in adults with chronic pain: a prospective case series

Journal of Medical Case Reports
Background In adults with chronic pain, mild-to-moderate withdrawal symptoms during medically directed opioid tapering in the outpatient setting may not be accompanied by hypertension or tachycardia.
Megan M. Ellis, Nathan D. Eberhart, Nafisseh S. Warner, W. Michael Hooten   +3 more
doaj   +1 more source

People experiencing homelessness and their experiences with substance use services for alcohol treatment in England: Journey mapping based on semi‐structured interviews

Addiction, EarlyView.
Abstract Background and aims Alcohol consumption at high levels is common among people experiencing homelessness and contributes to inequalities. In relative terms these individuals are underrepresented in substance use services. This study captured common trajectories and identified barriers and facilitators to accessing treatment among a group of ...
Vera Helen Buss, Jamie Brown, Melissa Oldham, Sarah E. Jackson, Lion Shahab, Dimitra Kale, Sharon Cox   +6 more
wiley   +1 more source

Prescribed pharmaceutical alternatives initiative coinciding with reductions in unregulated street opioid use among young people who use drugs: An interrupted time series analysis

Addiction, EarlyView.
Abstract Background and aims In British Columbia, Canada, an initiative was implemented in 2020 to reduce overdose mortality by prescribing pharmaceutical opioids (primarily hydromorphone) as a substitute for the toxic unregulated drug supply. This study estimated changes in the level and trend of unregulated opioid use and non‐prescribed hydromorphone
Erica McAdam, Mohammad Karamouzian, Michael John Milloy, Carmen Verdicchio, Eric C. Sayre, Kanna Hayashi, Thomas Kerr, Kora DeBeck   +7 more
wiley   +1 more source

Prescribed alternative stimulants among people who use unregulated stimulants: Examining the association between maximum dose reached and medication discontinuation in the first 3 years of implementation in British Columbia, Canada

Addiction, EarlyView.
Abstract Background and aims In 2020, British Columbia (BC), Canada, introduced ‘Prescribed Alternatives’ (PA) as an approach to offering regulated substances to people accessing the unregulated supply. This study aimed to estimate and compare prescribing characteristics of dextroamphetamine and methylphenidate stimulant PAs in BC, to estimate ...
Bin Zhao, Kevin Hu, Roshni Desai, Shania Au, Kali‐olt Sedgemore, Vitor Tardelli, Addie Carter, Paxton Bach, Christian Schutz, Amanda Slaunwhite, Alexis Crabtree, Heather Palis   +11 more
wiley   +1 more source

Clinicians' and people who use drugs' perspectives on artificial intelligence in addiction medicine

Addiction, EarlyView.
Abstract Background and aims Artificial intelligence (AI) may improve addiction medicine workflows and health outcomes but raises questions about data privacy and unintended harms for people who use drugs (PWUD). This qualitative study aimed to understand the perspectives of clinicians and PWUD regarding perceived benefits and concerns about clinical ...
Patrick J. A. Kelly, Elizabeth Chen, Amelia Bailey, Katie Biello, Brandon D. L. Marshall, Josiah D. Rich, Jaclyn M. W. Hughto   +6 more
wiley   +1 more source

A decade of cannabis‐related hospital admissions in Victoria, Australia: A retrospective observational study

Addiction, EarlyView.
Abstract Background and aims Over the past decade, there has been increased lifetime use of illicit and medical cannabis, underscoring the need to examine public health impacts. This includes reports of increased cannabis‐related psychosis. In this context, this study aimed to determine all cannabis‐related hospital admissions in Victoria, Australia ...
Myfanwy Graham, Janneke Berecki‐Gisolf, Jane Hayman, Adrian Carter, Shalini Arunogiri, Suzanne Nielsen   +5 more
wiley   +1 more source