Results 71 to 80 of about 45,788 (261)

Anxiety-like behavior during protracted morphine withdrawal is driven by gut microbial dysbiosis and attenuated with probiotic treatment

Gut Microbes
The development of anxiety during protracted opioid withdrawal heightens the risk of relapse into the cycle of addiction. Understanding the mechanisms driving anxiety during opioid withdrawal could facilitate the development of therapeutics to prevent ...
Mark Oppenheimer, Junyi Tao, Shamsudheen Moidunny, Sabita Roy   +3 more
doaj   +1 more source

Sublingual Zolpidem for MRI in Claustrophobic Patients: A Prospective, Non‐Randomized Noninferiority Study

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Claustrophobia during MRI may lead to examination interruption, motion artifacts, prolonged acquisition time, and reduced diagnostic quality, frequently requiring intravenous sedation to ensure successful examination completion and adequate image acquisition.
Beatriz Birelli do Nascimento, Fernando de Sá Del Fiol, Marcus Vinicius Birelli do Nascimento, Lucas Bueno de Oliveira, Samanta Aparecida Alves, Lucas do Nascimento Bernardes   +5 more
wiley   +1 more source

Pain management and opioid use after caesarean section: a prospective observational cohort study

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background Effective pain management after caesarean section (CS) is vital. Standard fixed‐quantity discharge opioid prescribing may not align with individual clinical requirements. Aim To determine the adequacy of standard fixed‐quantity discharge supply of opioid analgesic after CS, evaluate post‐CS opioid consumption, and identify variables
Charis Lau, Andrew Vuong, Gihara Gallage, Jane Huang, Manpreet Singh Bhangu, Shahad Saleh, Rita Wardan, Tanita Botha, Vivek B. Nooney   +8 more
wiley   +1 more source

Challenges of Pain in Parkinson's Disease: Results from the OCEAN Study

Movement Disorders, EarlyView.
Abstract Background Pain is a common non‐motor symptom in Parkinson’s disease (PD) and is often associated to fluctuations. Objective The OpiCapone Effect on motor fluctuations and pAiN (OCEAN) study evaluated the effect of opicapone on fluctuation‐related pain when added to levodopa therapy in PD patients.
Kallol Ray Chaudhuri, Joaquim J. Ferreira, Angelo Antonini, Olivier Rascol, Monica M. Kurtis, Alexander Storch, José‐Francisco Rocha, Raquel Costa, Diogo Magalhães, Guillermo Castilla‐Fernández, Helena C. Brigas, Joerg Holenz, Per Odin, on behalf of the OCEAN study group   +13 more
wiley   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Government as orchestrator: Ecosystem transformation at scale and speed

Strategic Management Journal, EarlyView.
Abstract Research Summary Grand challenges are ecosystem challenges: success depends on aligning a multilateral set of public and private sector actors whose interdependent contributions determine whether a mission is achieved. This study examines how government can orchestrate ecosystem alignment by leveraging distinctive capabilities to deliver ...
Ron Adner
wiley   +1 more source

Effect of transcutaneous electrical nerve stimulation on physical activity and pain evaluation in osteoarthritic dogs

Veterinary Record, EarlyView.
Abstract Background Osteoarthritis (OA) causes chronic pain and reduces welfare in dogs. Standard treatments may be inadequate or associated with adverse effects, prompting investigation of alternative therapies. Transcutaneous electrical nerve stimulation (TENS) is a non‐pharmacological pain management method, but evidence for its efficacy in canine ...
Anja Pedersen, Johanna Penell, Emil Olsen, Heli Hyytiäinen, Franck Forterre, Anna Bergh   +5 more
wiley   +1 more source

Dysrhythmias with Loperamide Used for Opioid Withdrawal

The Journal of the American Board of Family Medicine, 2017
The antidiarrheal loperamide has had a recent, drastic increase in off-label use as an alternative treatment for symptoms of opioid withdrawal. The concept of this is easily discovered on the Internet and social media, where there are multiple blogs and forums promoting loperamide use at doses of 70 to 200 mg per day.
Nicki D, Vithalani, Christopher, Heron, Ravishankar E, Rao, Anthony F, Cardell, Mark B, Stephens   +4 more
openaire   +2 more sources

Single‐dose enflicoxib versus a 7‐day course of firocoxib for postoperative pain control in dogs undergoing orthopaedic surgery: A multicentre, randomised, masked, non‐inferiority study

Veterinary Record, EarlyView.
Abstract Background Perioperative analgesia is essential in dogs undergoing orthopaedic surgery, and enflicoxib's long duration makes single‐dose administration attractive. Methods A prospective, multicentre, randomised, masked trial compared enflicoxib (8 mg/kg) given 24 hours before surgery with firocoxib (5 mg/kg) given daily for 7 days. Two hundred
Marta Salichs, José I. Redondo, Anabel Blasco‐Moreno, Llorenç Badiella, Josep Homedes   +4 more
wiley   +1 more source

Cognitive function during early abstinence from opioid dependence: a comparison to age, gender, and verbal intelligence matched controls

BMC Psychiatry, 2006
Background Individuals with opioid dependence have cognitive deficits during abuse period in attention, working memory, episodic memory, and executive function.
Kähkönen Seppo, Autti Taina, Kivisaari Reetta, Rapeli Pekka, Puuskari Varpu, Jokela Olga, Kalska Hely   +6 more
doaj   +1 more source