Results 121 to 130 of about 166,726 (313)

Impact of parameter settings on the estimation of drug exposure with the individualized dispensing patterns method

British Journal of Clinical Pharmacology, EarlyView.
Aim To assess the impact of parameter settings when using the individualized dispensing patterns (IDP) method to estimate exposure duration from dispensing data. Methods We conducted a cohort study using a 2% representative sample of the French healthcare insurance database from 2013 to 2022.
Laëtitia Gosselin, Clara Lévy, Noémie Sève, Thierry Blanchon, Marianne Sarazin, Louise Rossignol, Maryse Lapeyre‐Mestre, Nathanaël Lapidus, Olivier Steichen   +8 more
wiley   +1 more source

Opioids for chronic pain: a knowledge assessment of nonpain specialty providers [PDF]

, 2016
Amy CS Pearson, Jason S Eldrige, Susan M Moeschler, W Michael Hooten Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA Introduction: Although the majority of opioids in the US are prescribed by nonpain specialists, these providers often ...
Pearson ACS, Hooten WM, Eldrige JS, Moeschler SM   +3 more
core  

Exploring profile, effects and toxicity of novel synthetic opioids and classical opioids via Twitter: A qualitative study

Emerging Trends in Drugs, Addictions, and Health
Background and aims: Novel synthetic opioids’ use has been increasing over the last decade and the opioid epidemic has attributed to 70 % of drug-related deaths worldwide.
Abdullah Al-Hamid, Carys Tudor, Sulaf Assi   +2 more
doaj   +1 more source

Spray‐Dried Engineered Escherichia coli Whole‐Cell Biocatalysts Enable Cell Recycling and In Vivo α‐Ketoglutarate and NADPH Regeneration for Efficient Codeine Manufacture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian, Carlos Horacio Luna‐Flores, Xu Li, Sally L. Gras, Robert E. Speight   +4 more
wiley   +1 more source

Opioids, opioids and more opioids [PDF]

British Journal of Pain, 2019
openaire   +2 more sources

Glycosylated dendrimer nanoamplifiers hijack DNA damage‐immune crosstalk for enhanced dual‐track therapy of orthotopic glioblastoma

BMEMat, EarlyView.
A glycosylated dendrimer nanoamplifier hijacks DNA damage‐immune crosstalk for enhanced radio‐immunotherapy of glioblastoma. The responsive release of demethylcantharidin simultaneously blocks repair‐mediated resistance by inhibiting DNA repair and overcomes adaptive immune resistance.
Cong Song, Binghan Liu, Junjie Liu, Ce Li, Wenqing Man, Xurui Sun, Chang Yuan, Yanjun Wang, Hong Pan, Shuanglian Wang, Zhiming Zheng   +10 more
wiley   +1 more source

Evidence on opioids [PDF]

, 2004
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF caption (viewed on May 31, 2012)"Updated 12 ...

core  

VER-01 Shows Enhanced Gastrointestinal Tolerability, Superior Pain Relief, and Improved Sleep Quality Compared to Opioids in Treating Chronic Low Back Pain: A Randomized Phase 3 Clinical Trial

Pain and Therapy
Introduction Chronic low back pain (CLBP) affects over half a billion people worldwide. Current pharmacologic treatments, comprising mainly non-steroidal anti-inflammatory drugs and opioids, offer limited efficacy and pose significant risks, warranting ...
Winfried Meissner, Charles Argoff, Sabine Sator, Volker Schoder, Matthias Karst   +4 more
doaj   +1 more source

Variations in Human Trigeminal and Facial Nerve Branches and Foramina Identified by Dissection and Microcomputed Tomography

Clinical Anatomy, EarlyView.
ABSTRACT The aim of this study was to identify branches of the trigeminal and facial nerves (FNs) relevant to surgical incisions and injections and the scalp block techniques in the frontotemporal region, and to determine their relationships with superficial vascular structures and bony landmarks.
Hannah L. Grimes, Valentina Pizzuti, Maria A. Wright, Kane P. J. Colston, Thomas Santarius, Susan Jones   +5 more
wiley   +1 more source

Designing a primary care pharmacist-led review for people treated with opioids for persistent pain: a multi-method qualitative study. [PDF]

Opioids are frequently prescribed for persistent non-cancer pain despite limited evidence of long-term effectiveness and risk of harm. Evidence-based interventions to address inappropriate opioid prescribing are lacking. To explore perspectives of people
Cornwall, Nicola, Harrisson, Sarah A, Ashworth, Julie, Jinks, Clare, Dikomitis, Lisa, White, Simon, Mallen, Christian, Woodcock, C., Knaggs, Roger, Santer, M., Pincus, Tamar, PROMPPT research team, Hodgson, Eleanor, Helliwell, Toby   +13 more
core   +1 more source