Results 151 to 160 of about 315,380 (361)

Targeted Delivery of Lidocaine in Breast Cancer Cells via Zeolitic Imidazolate Framework‐8 Nanoparticles

ChemPhysChem, EarlyView.
Drug repositioning of lidocaine from local anesthetic to theranostic agent for breast cancer cells is enhanced by its encapsulation inside ZIF‐8 metal–organic framework. The aim of this article is to use zeolitic imidazolate framework‐8 (ZIF‐8) metal–organic frameworks (MOFs) as drug delivery system for lidocaine, a local anesthetic with recently ...
Nicola di Nicola, Luca Giacchi, Marco Vandone, Marcello Crucianelli, Leonardo Guidoni, Valentina Colombo, Nadia Rucci, Andrea Lazzarini   +7 more
wiley   +1 more source

Impact of First‐of‐Its‐Kind Patient‐Facing Pharmacogenetics Tool on Dosing Decisions and Treatment Outcomes

Clinical Pharmacology &Therapeutics, EarlyView.
Germline pharmacogenetics (PGx) is increasingly used to tailor medication selection/dosing. However, existing systems primarily communicate PGx results to providers, limiting direct patient engagement. To address this, we developed YourPGx Oncology, an innovative patient‐facing portal that delivers multi‐gene PGx results (CYP2D6, UGT1A1, DPYD) through ...
Youngwoo Cho, Sami Elahi, Matthew M. Jack, John Campbell, Emily Smith, Randall W. Knoebel, David George, Larry House, Kiang‐Teck J. Yeo, Theodore Karrison, Samuel L. Volchenboum, David O. Meltzer, Russell Z. Szmulewitz, Everett E. Vokes, Mark J. Ratain, Peter H. O'Donnell   +15 more
wiley   +1 more source

Opioid-mediated suppression of cultured peripheral blood mononuclear cell respiratory burst activity. [PDF]

, 1987
Phillip K. Peterson, Burt M. Sharp, Genya Gekker, Charles Brummitt, W. F. Keane   +4 more
openalex   +1 more source

Retrospective Evaluation of Novel Synthetic Opioids and Xylazine Chronic Intake by Post‐Mortem Hair Testing

Drug Testing and Analysis, EarlyView.
The study presents a validated UPLC‐MS/MS method applied for the detection of fentanyl, NPFs, xylazine, nitazenes in hair samples from 250 post‐mortem cases collected at the Jefferson County Coroner/Medical Examiner's Office (Birmingham, AL, USA). In 52% of the analyzed hair samples, fentanyl, its main metabolites, and related analogs were detected ...
Marco Ballotari, Nicola Pigaiani, Anna Bacci, Karen S. Scott, Gregory G. Davis, Rossella Gottardo, Federica Bortolotti   +6 more
wiley   +1 more source

Global Overview of Drug Demand and Supply: Latest Trends, Cross-cutting Issues [PDF]

, 2017
An estimated quarter of a billion people, or around 5 per cent of the global adult population, used drugs at least once in 2015. Even more worrisome is the fact that about 29.5 million of those drug users, or 0.6 per cent of the global adult population ...

core  

Opioid antagonist (naltrexone) modulation of cerebellar development: histological and morphometric studies [PDF]

, 1986
IS Zagon, McLaughlin Pj
openalex   +1 more source

Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo‐Pyridyl Synthetic Cannabinoid Receptor Agonist CH‐FUBBMPDORA

Drug Testing and Analysis, EarlyView.
Another Chinese generic ban‐evading SCRA, CH‐FUBBMPDORA, has emerged. This study reports its first identification in Europe, its analytical characterization (NMR, Raman, FTIR, GC–MS, and HRMS), its cannabinoid activation potential in a βarr2 recruitment assay, and its metabolization profile.
Marie H. Deventer, Maria Carmela Emanuele, Brianna N. Stang, Katleen Van Uytfanghe, Jessica Masson, Xavier Bouvot, Catherine Lamoureux, Alessandro Proposito, Fabiano Reniero, Margaret V. Holland, Alex J. Krotulski, Luisa Mannina, Christophe P. Stove, Claude Guillou   +13 more
wiley   +1 more source

High molecular weight opioid-containing proteins in striatum.

, 1978
Randolph V. Lewis, S Stein, Louise Gerber, Menachem Rubinstein, Sidney Udenfriend   +4 more
openalex   +1 more source

Evidence for a Dual Mechanism in the Anesthetic Action of an Opioid Peptide [PDF]

, 1985
Barbara A. Dodson, Keith W. Miller
openalex   +1 more source

Workplace Drug Testing—Prevalence of Positive Test Results, Most Common Substances, and Importance of Medical Review

Drug Testing and Analysis, EarlyView.
Among 23,900 urine and oral fluid drug tests from Swedish workplaces, 4.6% tested positive for controlled substances. Cannabis, amphetamine, cocaine and benzodiazepines were most common. Many samples containing opiates, amphetamine or benzodiazepines were MRO verified as being due to medical prescriptions, while cannabis or cocaine were almost entirely
Anders Helander, Fredrik Sparring
wiley   +1 more source