Results 161 to 170 of about 512,940 (405)
Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives
BioEssays, EarlyView.Breathing is typically automatic, ensuring homeostasis, but it is also shaped by emotion, behavior, and volition. This review synthesizes our current understanding of the flexible neural mechanisms that enable multimodal control of breathing, emphasizing the role of pontomedullary circuits.
Nathan A. Baertsch +4 more
wiley +1 more source
The Allosteric Mechanism of G‐Protein‐Coupled Receptors is Induced Fit, Not Conformational Selection
BioEssays, EarlyView.Allosteric signaling of G‐protein‐coupled receptors (GPCRs) involves a population shift from inactive to active receptor conformations upon binding of ligand agonists. Kinetic and structural data indicate that this population shift is induced by ligand binding to inactive receptor conformations prior to the conformational change from inactive to active.
Kazem Asadollahi +2 more
wiley +1 more source
Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application
BMEMat, EarlyView.The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah +9 more
wiley +1 more source
Editorial: Opioids and opioid-use disorders
Frontiers in Pharmacology, 2023 Giordano de Guglielmo +5 more
openaire +4 more sources
Clinical Anatomy, EarlyView.ABSTRACT The aim of this study was to identify branches of the trigeminal and facial nerves (FNs) relevant to surgical incisions and injections and the scalp block techniques in the frontotemporal region, and to determine their relationships with superficial vascular structures and bony landmarks.
Hannah L. Grimes +5 more
wiley +1 more source
Fashioning Appropriate Regulation of Opioids for Palliative Care [PDF]
, 2018 Palliative care specialists, who care for patients with serious, life-limiting illnesses such as cancer, are experts in evaluating and managing acute pain.
Albrecht, Tara +4 more
core +1 more source
Antinociceptive and Anti‐inflammatory Effect of Nicandrin B Isolated From Datura ferox in Zebrafish
Chemistry &Biodiversity, EarlyView.ABSTRACT Nicandrin B (Nic B), a withanolide isolated from Datura ferox leaves, was investigated for its antinociceptive and anti‐inflammatory effects in adult zebrafish (Danio rerio). Animals treated with Nic B (4, 20, and 40 mg/kg) showed no toxicity and maintained normal locomotor activity.
Jéssica Bezerra Maciel +15 more
wiley +1 more source
Use patterns of classic, novel, and herbal opioids
Emerging Trends in Drugs, Addictions, and HealthBackground: Data on use patterns and psychological and physical effects of novel synthetic opioids (NSOs) and herbal opioids like kratom (Mitragyna speciosa) lags behind that of classic opioids.
Elisabeth Prevete +6 more
doaj +1 more source
Baseline Assessment: Alaska's Capacity and Infrastructure for Prescription Opioid Misuse Prevention [PDF]
, 2017 The State of Alaska Department of Health and Social Services (DHSS), Division of Behavioral Health (DBH) was awarded the Partnerships for Success (PFS) grant by the Substance Abuse and Mental Health Services Administration (SAHMSA) in 2015.
Barnett, Jodi +3 more
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