Results 101 to 110 of about 28,309 (210)

Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation [PDF]

, 2020
Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive
Drovakova A., Giallongo S., Li Volti G., Lo Re O., Mazza T., Rappa F., Roskams T., Sanna P., Tsochatzis E., Van Haele M., Vinciguerra M., Vinh Luong T.   +11 more
core   +1 more source

1H NMR Fingerprinting of Medicinal Herbs Contain Chemical Drug Material Allopurinol

Majalah Obat Tradisional, 2018
A study to differentiate the pure medicinal herbs from the mix medicinal herbs with chemical drug material has been done. For this purpose, we conducted fingerprinting of commercial medicinal herbs and chemical drug material allopurinol using 1H-NMR ...
Adita Yuniati Puspitasari, Hanro Dwi Pranowo, Respati Tri Swasono, Tri Rini Nuringtyas   +3 more
doaj   +1 more source

PLS-based and regularization-based methods for the selection of relevant variables in non-targeted metabolomics data

Frontiers in Molecular Biosciences, 2016
Non-targeted metabolomics constitutes a part of systems biology and aims to determine many metabolites in complex biological samples. Datasets obtained in non-targeted metabolomics studies are multivariate and high-dimensional due to the sensitivity of ...
Renata Bujak, Emilia Daghir-Wojtkowiak, Roman Kaliszan, Michal Jan Markuszewski   +3 more
doaj   +1 more source

Metabolomics of dates (Phoenix dactylifera) reveals a highly dynamic ripening process accounting for major variation in fruit composition [PDF]

, 2015
BACKGROUND: Dates are tropical fruits with appreciable nutritional value. Previous attempts at global metabolic characterization of the date metabolome were constrained by small sample size and limited geographical sampling.
Anna Halama, Edward D. Karoly, Ilhame Diboun, Joel Malek, Karsten Suhre, Maria Torres, Maryam Al-Rayyashi, Michaël Méret, Mohamed Elrayess, Robert P. Mohney, Sweety Mathew   +10 more
core   +1 more source

Combined OPLS-DA and decision tree as a strategy to identify antimicrobial biomarkers of volatile oils analyzed by gas chromatography–mass spectrometry

Revista Brasileira de Farmacognosia, 2018
Abstract Bioguided isolation to discriminate antimicrobial compounds from volatile oils is a time- and money-consuming process. Considering the limitations of the classical methods, it would be a great improvement to use chemometric techniques to identify putative biomarkers from volatile oils.
Santos,Felipe A. dos, Sousa,Ingrid P., Furtado,Niege A.J.C., Costa,Fernando B. Da   +3 more
openaire   +2 more sources

Nanoflow-nanospray mass spectrometry metabolomics reveals disruption of the urinary metabolite profiles of HIV-positive patients on combination antiretroviral therapy [PDF]

, 2017
Background: The use of combination antiretroviral therapy (cART) has substantially improved the outlook for patients with HIV infection. However, lifelong exposure to cART is also associated with adverse metabolic changes and an enhanced risk of renal ...
Abdul-Sada, Alaa, Bremner, Stephen A, Chetwynd, Andrew J, Gilleece, Yvonne, Hill, Elizabeth M, Holt, Stephen G, Samarawickrama, Amanda, Vera, Jaime H   +7 more
core   +1 more source

¹H-¹³C NMR-based profiling of biotechnological starch utilization [PDF]

, 2016
Starch is used in food- and nonfood applications as a renewable and degradable source of carbon and energy. Insight into the chemical detail of starch degradation remains challenging as the starch constituents amylose and amylopectin are homopolymers. We
Meier, Sebastian, Sundekilde, Ulrik K.
core   +2 more sources

Quality evaluation of Polygonatum sibiricum slices from different regions based on appearance traits and multi-index metabolites combined with TOPSIS and gray relation analysis

Frontiers in Pharmacology
IntroductionTraditional Chinese medicine quality control faces challenges, lacking multidimensionality and reliable quantitative evidence. Comprehensive evaluation models based on external characteristics and multiple indicator metabolites are the future
Cheng Wang, Cheng Wang, Ju Ye, Sisi Jiang, Sisi Jiang, Xuguang He, Xuguang He, Min Ma, Min Ma, Li Yin   +9 more
doaj   +1 more source

基于气相色谱-离子迁移谱技术分析不同预处理 技术对压榨山茶油风味的影响Analysis of effect of different pretreatment technology on the flavor of pressed oil-tea camellia seed oil based on gas chromatography-ion mobility spectroscopy

Zhongguo youzhi
旨在提升山茶油风味品质，采用气相色谱-离子迁移谱（GC-IMS）技术分析微波、烘烤、蒸制3种预处理技术对压榨山茶油中挥发性成分的影响，并结合正交偏最小二乘判别分析（OPLS-DA）、相对气味活度值（ROAV）和聚类分析比较不同预处理压榨山茶油挥发性成分的差异。结果表明：不同预处理压榨山茶油中共鉴定出40种挥发性成分，其中醛类18种（40.02%~51.88%）、醇类9种（10.99%~19.85%）、酮类6种（19.37%~27.35%）、酯类3种（4.21%~11.44%）、吡嗪类2种（1.25%~6.
彭丝兰1,2，刘思思2，易有金1，刘汝宽2，李昌珠2，肖志红2,3 PENG Silan1,2，LIU Sisi2，YI Youjin1，LIU Rukuan2，LI Changzhu2，XIAO Zhihong2,3
doaj   +1 more source

A targeted proteomic multiplex CSF assay identifies increased malate dehydrogenase and other neurodegenerative biomarkers in individuals with Alzheimer's disease pathology [PDF]

, 2016
Alzheimer's disease (AD) is the most common cause of dementia. Biomarkers are required to identify individuals in the preclinical phase, explain phenotypic diversity, measure progression and estimate prognosis.
Andreasson, U, Bliss, E, Fox, NC, Heslegrave, AJ, Heywood, WE, Johansson, P, Magdalinou, NK, Mills, K, Paterson, RW, Schott, JM, Sirka, E, Slattery, CF, Svensson, J, Toombs, J, Zetterberg, H   +14 more
core   +1 more source