Results 151 to 160 of about 4,457,338 (303)

The relationship of alcohol to blood pressure: The INTERMAP Study

, 2012
Adverse blood pressure (BP) is a major risk factor for cardiovascular disease. The World Health Organisation Global Burden of Disease Comparative Risk Analysis study (2000) reported that regular consumption of alcohol elevated BP and attributed 16% of ...
Chan, Queenie, Chan, Queenie
core   +1 more source

Alterations in brain metabolites in rats with experimental periodontitis: A metabolomic approach

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis (PD) is a chronic inflammatory disease with systemic effects. Emerging evidence suggests a link between periodontal inflammation and neurological changes, but the biochemical mechanisms in key brain regions, such as the hippocampus and amygdala, remain unclear.
Ramona Ramalho de Souza Pereira, Caíque Olegário Diniz e Magalhães, Elizabeth Luciana Marinho Miguel, Larissa Vieira Toledo, Débora Ribeiro Orlando, Alan Rodrigues Teixeira Machado, Bruno Del Bianco Borges, Luciano José Pereira, Marco Fabrício Dias‐Peixoto, Eric Francelino Andrade   +9 more
wiley   +1 more source

Unravelling the metabolomic diversity of pigmented and non-pigmented traditional rice from Tamil Nadu, India

BMC Plant Biology
Rice metabolomics is widely used for biomarker research in the fields of pharmacology. As a consequence, characterization of the variations of the pigmented and non-pigmented traditional rice varieties of Tamil Nadu is crucial.
Venkatesan Subramanian, Udhaya Nandhini Dhandayuthapani, Senthilraja Kandasamy, Jidhu Vaishnavi Sivaprakasam, Prabha Balasubramaniam, Mohan Kumar Shanmugam, Sriram Nagappan, Subramanian Elangovan, Umesh Kanna Subramani, Kumaresan Palaniyappan, Geethalakshmi Vellingiri, Raveendran Muthurajan   +11 more
doaj   +1 more source

Peripheral versus Marrow Lipidomics in Patients with Severe Aplastic Anemia: Potential Indicators for Early Immunosuppressive Treatment Response

Lipids, EarlyView.
ABSTRACT This study aimed to explore the differences of peripheral blood (PB) and bone marrow serum lipidomic profiles in severe aplastic anemia (SAA) patients and their significance in predicting earlier immunosuppressive therapy (IST) response. A cohort of 11 newly diagnosed SAA patients and 15 healthy controls were enrolled between June 2020 and ...
Zexing Sun, Yilei Hong, Yaonan Hong, Chuanao Xin, Qi Liu, Huijin Hu, Yingying Shen, Ying Chen, Shan Liu, Yiping Shen, Yuhong Zhou, Dijiong Wu   +11 more
wiley   +1 more source

Plasma deoxysphingolipids: a novel class of biomarkers for the metabolic syndrome? [PDF]

, 2018
Aims/hypothesis: Sphingolipid synthesis is typically initiated by the conjugation of l-serine and palmitoyl-CoA, a reaction catalysed by serine palmitoyltransferase (SPT). SPT can also metabolise other acyl-CoAs (C12 to C18) and other amino acids such as
Bianchi, R., Drexel, H., Ernst, D., Hornemann, T., Lauria, G., Othman, A., Porretta-Serapiglia, C., Rein, P., Rütti, M., Saely, C., von Eckardstein, A.   +10 more
core  

Computational Evaluation of Statin Analogs Targeting HMG‐CoA Reductase for Coronary Artery Disease Treatment

ChemistryOpen, EarlyView.
Molecular dynamics analysis of novel statin analogs shows that binding induces superior stabilization of HMG‐CoA reductase. As shown by the solvent‐accessible surface area profile, ligand‐induced rigidity offers a new, effective strategy for drug design. Cardiovascular diseases remain a leading cause of global mortality.
Yoshua B. Mtulo, Geradius Deogratias, James E. Mgaya, Andrew S. Paluch, Lucas Paul   +4 more
wiley   +1 more source

Impact of harvest periods of Sichuan pepper on Sichuan pepper-flavoured chicken using electronic nose, electronic tongue, and chromatography

Food Chemistry: X
This study compared Sichuan pepper harvested at five stages (July–September) for preparing Sichuan pepper-flavoured chicken. Electronic nose and tongue analyses separated the control from peppered samples and further distinguished early (July–august ...
Lian He, Zongyuan Lu, Xuemei Cai, Kaixian Zhu, Chengjian Xu, Dan Lin, Zhiyong Hou, Sze Ying Leong, Nallammai Singaram, Cui Yang, Sook Wah Chan, Hua Peng, Minglu Lan   +12 more
doaj   +1 more source

Alterations in Metabolites Associated With Umbilical Cord Blood in Monozygotic Twins Discordant for Congenital Heart Disease

Pediatric Discovery, EarlyView.
This study found that the metabolomic signature of umbilical venous cord blood in congenital heart disease (CHD) differs from that of healthy monozygotic (MZ) co‐twins. Dysregulation of metabolic pathways like glucose, lipid, and amino acid metabolism, along with altered metabolites, helps understand CHD predisposition.
Fang Xiang, Xiao Yuan, Yi Yang, Philip N. Baker, Mark D. Kilby, Chao Tong, Xi Yuan   +6 more
wiley   +1 more source

Integrative Modeling in the Age of Machine Learning: A Summary of HADDOCK Strategies in CAPRI Rounds 47–55

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The HADDOCK team participated in CAPRI rounds 47–55 as server, manual predictor, and scorers. Throughout these CAPRI rounds, we used a plethora of computational strategies to predict the structure of protein complexes. Of the 10 targets comprising 24 interfaces, we achieved acceptable or better models for 3 targets in the human category and 1 ...
Victor Reys, Marco Giulini, Vlad Cojocaru, Anna Engel, Xiaotong Xu, Jorge Roel‐Touris, Cunliang Geng, Francesco Ambrosetti, Brian Jiménez‐García, Zuzana Jandova, Panagiotis I. Koukos, Charlotte van Noort, João M. C. Teixeira, Siri C. van Keulen, Manon Réau, Rodrigo V. Honorato, Alexandre M. J. J. Bonvin   +16 more
wiley   +1 more source

Weakly Polar Organic Additive Inducing Capacity‐Dependent Zinc Growth Transition via Indirect Solvation and Adsorption Engineering in Aqueous Electrolytes

Small Methods, EarlyView.
Dimethyl isosorbide (DMI) regulates Zn solvation and stabilizes the Zn/electrolyte interface, suppressing corrosion, ZBS, and dendrites, enabling uniform plating and long‐life, high‐rate aqueous zinc batteries. ABSTRACT Aqueous zinc batteries have emerged as promising candidates for safe and sustainable energy storage.
Sung‐Ho Huh, Beom‐Keun Cho, Yao‐Peng Chen, So Hee Kim, Jong‐Seong Bae, Xiang Chen, Seung‐Ho Yu   +6 more
wiley   +1 more source