Results 41 to 50 of about 38,044 (266)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

A Comparative Study on Processed Panax ginseng Products Using HR-MAS NMR-Based Metabolomics

Molecules, 2020
Panax ginseng is processed to diversify efficacy. Four processed ginsengs containing white ginseng (WG), tae-geuk ginseng (TG), red ginseng (RG), and black ginseng (BG) were analyzed using nuclear magnetic resonance (NMR) spectroscopy for screening ...
Dahye Yoon, Woo Cheol Shin, Young-Seob Lee, Suhkmann Kim, Nam-In Baek, Dae Young Lee   +5 more
doaj   +1 more source

OPLS-DA of serum metabolites obtained from cultured and wild female eels.

, 2019
(A) OPLS-DA of serum metabolites obtained from cultured and wild eels. (B) S-plot generated from OPLS-DA.
Miyuki Mekuchi (2503714), Takeshi Hano (2505832), Masato Higuchi (6686000), Hitoshi Imaizumi (4818915)   +3 more
core   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

OPLS-DA modeling associated S-Plot.

, 2017
S-plot of the cases with a positive blood culture versus blood culture negative controls: S–Plot obtained from OPLS-DA regression analysis is shown here.
Mayank Saraswat (124763), Sakari Joenväärä (3779917), Risto Renkonen (172507), Johanna Kaartinen (3779914), Asko Järvinen (156899), Pentti Kuusela (236093)   +5 more
core   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Prediction of Antimicrobial and Antioxidant Activities of Mexican Propolis by 1H-NMR Spectroscopy and Chemometrics Data Analysis

Molecules, 2017
A feasibility study to predict antimicrobial and antioxidant activity properties of propolis extracts using 700-MHz 1H-NMR spectra and multivariate regression data analysis is presented.
J. Fausto Rivero-Cruz, Eduardo Rodríguez de San Miguel, Sergio Robles-Obregón, Circe C. Hernández-Espino, Blanca E. Rivero-Cruz, José Pedraza-Chaverri, Nuria Esturau-Escofet   +6 more
doaj   +1 more source

Evaluating the physiological and biochemical responses of melon plants to NaCl salinity stress using supervised and unsupervised statistical analysis

Plant Stress, 2022
Salinity is a major environmental issue affecting plant production, particularly in the Middle East. Multivariate data analysis including principal component analysis (PCA), hierarchical clustering analysis (HCA), and orthogonal projections to latent ...
Behrooz Sarabi, Jaleh Ghashghaie
doaj   +1 more source

OPLS-DA plots of four data sets: Resistant Mock vs Susceptible Mock, Resistant Treated vs Susceptible Treated, Susceptible Mock vs Susceptible Treated, Resistant Treated vs Resistant Mock.

, 2020
OPLS-DA plots of four data sets: Resistant Mock vs Susceptible Mock, Resistant Treated vs Susceptible Treated, Susceptible Mock vs Susceptible Treated, Resistant Treated vs Resistant Mock.
Hassan Javed Chaudhary (6400664), Shafiq ur Rehman (8442807), Urooj Haroon (8442801), Umar Masood Quraishi (6322394), Maria Khizar (8442789), Sadia Saleem (8442792), Muhammad Ashraf (133265), Sadia Latif (8442798), Syed Waqas Hassan (8442804), Jianxin Shi (90453), Fiza Liaquat (8442795), Muhammad Farooq Hussain Munis (8442810)   +11 more
core   +1 more source

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source