Results 111 to 120 of about 40,625 (235)

Discovery of non-retinoid compounds that suppress the pathogenic effects of misfolded rhodopsin in a mouse model of retinitis pigmentosa.

PLoS Biology
Pathogenic mutations that cause rhodopsin misfolding lead to a spectrum of currently untreatable blinding diseases collectively termed retinitis pigmentosa. Small molecules to correct rhodopsin misfolding are therefore urgently needed.
Joseph T Ortega, Jacklyn M Gallagher, Andrew G McKee, Yidan Tang, Miguel Carmena-Bargueňo, Maria Azam, Zaiddodine Pashandi, Marcin Golczak, Jens Meiler, Horacio Pérez-Sánchez, Jonathan P Schlebach, Beata Jastrzebska   +11 more
doaj   +1 more source

Innovative Optogenetic Strategies for Vision Restoration

Frontiers in Cellular Neuroscience, 2018
The advent of optogenetics has ushered in a new era in neuroscience where spatiotemporal control of neurons is possible through light application. These tools used to study neural circuits can also be used therapeutically to restore vision.
Cameron K. Baker, John G. Flannery
doaj   +1 more source

Expression of the excitatory opsin ChRERα can be traced longitudinally in rat and nonhuman primate brains with PET imaging [PDF]

, 2023
Jordi Bonaventura, Matthew A. Boehm, Hank P. Jedema, Óscar Solís, Marco Pignatelli, Xiaowei Song, Hanbing Lu, Christopher T. Richie, Shiliang Zhang, Juan L. Gomez, Sherry Lam, Marisela Morales, Omar A. Gharbawie, Martin G. Pomper, Elliot A. Stein, Charles W. Bradberry, Michael Michaelides   +16 more
openalex   +1 more source

The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation [PDF]

, 2002
Mutations in the photopigment rhodopsin are the major cause of autosomal dominant retinitis pigmentosa. The majority of mutations in rhodopsin lead to misfolding of the protein.
Cheetham, ME, Luthert, PJ, Munro, PMG, Saliba, RS   +3 more
core  

Multiple Pathways of Visual Adaptations for Water Column Usage in an Antarctic Adaptive Radiation

Ecology and Evolution
Evolutionary transitions in water column usage have played a major role in shaping ray‐finned fish diversity. However, the extent to which vision‐associated trait complexity and water column usage is coupled remains unclear.
Ella B. Yoder, Elyse Parker, Bruno Frédérich, Alexandra Tew, Christopher D. Jones, Alex Dornburg   +5 more
doaj   +1 more source

Expression of opsin and visual cycle-related enzymes in fetal rat skin keratinocytes and cellular response to blue light

Biochemistry and Biophysics Reports
The mechanism by which the skin, a non-visual tissue, responds to light remains unknown. To date, opsin expression has been demonstrated in keratinocytes, melanocytes, and fibroblasts, all of which are skin-derived cells.
Hiroyuki Yamamoto, Momo Okada, Yoshikazu Sawaguchi, Toshiyuki Yamada   +3 more
doaj   +1 more source

Visual opsin expression and morphological characterisation of retinal photoreceptors in the pouched lamprey (Geotria australis, Gray).

, 2021
Warrington, Rachael E, Davies, Wayne, Hemmi, Jan M, Hart, Nathan S, Potter, Ian C, Collin, Shaun, Hunt, David M   +6 more
openalex   +1 more source

Seeing again through ancient eyes: microbial opsins and the promise of restoring vision [PDF]

, 2011
Anthony Vugler, Ma’ayan Semo, Peter Coffey   +2 more
openalex   +1 more source

Light-Driven Regeneration of Cone Visual Pigments through a Mechanism Involving RGR Opsin in Müller Glial Cells [PDF]

, 2019
Ala Morshedian, Joanna J. Kaylor, Sze Yin Ng, Avian Tsan, Rikard Frederiksen, Tongzhou Xu, Lily Yuan, Alapakkam P. Sampath, Roxana A. Radu, Gordon Fain, Gabriel H. Travis   +10 more
openalex   +1 more source

Molecular advances to study the function, evolution and spectral tuning of arthropod visual opsins

, 2022
Marjorie A. Liénard, Wendy A. Valencia‐Montoya, Naomi E. Pierce   +2 more
openalex   +1 more source