Results 31 to 40 of about 40,625 (235)

Number and distribution of mouse retinal cone photoreceptors: differences between an albino (Swiss) and a pigmented (C57/BL6) strain. [PDF]

PLoS ONE, 2014
We purpose here to analyze and compare the population and topography of cone photoreceptors in two mouse strains using automated routines, and to design a method of retinal sampling for their accurate manual quantification.
Arturo Ortín-Martínez, Francisco M Nadal-Nicolás, Manuel Jiménez-López, Juan J Alburquerque-Béjar, Leticia Nieto-López, Diego García-Ayuso, Maria P Villegas-Pérez, Manuel Vidal-Sanz, Marta Agudo-Barriuso   +8 more
doaj   +1 more source

The Effect of Cone Opsin Mutations on Retinal Structure and the Integrity of the Photoreceptor Mosaic [PDF]

, 2012
Purpose. To evaluate retinal structure and photoreceptor mosaic integrity in subjects with OPN1LW and OPN1MW mutations. Methods. Eleven subjects were recruited, eight of whom have been previously described.
Banin, Eyal, Carroll, Joseph, Connor, Thomas B., Jr., Cooper, Robert F., Dubis, Adam M., Dubra, Alfredo, Fishman, Gerald, Gardner, Jessica C., Genead, Mohamed, Hardcastle, Alison J., Hunt, David M., Michaelides, Michel, Mizrahi-Meissonnier, Liliana, Moore, Anthony T., Neitz, Jay, Neitz, Maureen, Nordgren, Rick, Sharon, Dror, Stepien, Kimberly E., Williams, David R.   +19 more
core   +2 more sources

Opsins: Evolution in Waiting [PDF]

Current Biology, 2005
Complete vertebrate genome sequencing has revealed a remarkable stability and uniformity in the protein-coding gene set, which at first glance might suggest that gene duplication events are relatively rare. This may be a red herring, or at least a red cichlid, as the Lake Malawi cichlid fishes show rapid and extensive duplication and diversification of
Trezise, A. E. O., Collin, S. P.
openaire   +3 more sources

S-opsin knockout mice with the endogenous M-opsin gene replaced by an L-opsin variant [PDF]

Visual Neuroscience, 2013
AbstractSpecific variants of human long-wavelength (L) and middle-wavelength (M) cone opsin genes have recently been associated with a variety of vision disorders caused by cone malfunction, including red-green color vision deficiency, blue cone monochromacy, myopia, and cone dystrophy. Strikingly, unlike disease-causing mutations in rhodopsin, most of
Scott H, Greenwald, James A, Kuchenbecker, Daniel K, Roberson, Maureen, Neitz, Jay, Neitz   +4 more
openaire   +2 more sources

Gene-based Therapy in a Mouse Model of Blue Cone Monochromacy

Scientific Reports, 2017
Cones are responsible for daylight, central, high acuity and color vision. Three proteins found in human cones, i.e. long-wavelength (L)-, middle-wavelength (M)-, and short-wavelength sensitive (S)-opsins, are responsible for red, green and blue color ...
Yuxin Zhang, Wen-Tao Deng, Wei Du, Ping Zhu, Jie Li, Fan Xu, Jingfen Sun, Cecilia D. Gerstner, Wolfgang Baehr, Sanford L. Boye, Chen Zhao, William W. Hauswirth, Ji-jing Pang   +12 more
doaj   +1 more source

High-Level Inducible Expression of Visual Pigments in Transfected Cells

BioTechniques, 1996
A method for high-level expression of a functionally active, recombinant human red cone opsin was developed by adding the coding sequence for the C-terminal epitope of bovine rhodopsin onto the C terminus of the cone opsin and cloning the resulting ...
Manija A. Kazmi, Robert A. Dubin, Carole Oddoux, Harry Ostrer   +3 more
doaj   +1 more source

Opsin Is a Phospholipid Flippase [PDF]

Current Biology, 2011
Polar lipids must flip-flop rapidly across biological membranes to sustain cellular life [1, 2], but flipping is energetically costly [3] and its intrinsic rate is low. To overcome this problem, cells have membrane proteins that function as lipid transporters (flippases) to accelerate flipping to a physiologically relevant rate.
Sakmar, TP, Menon, I, Huber, T, Sanyal, S, Banerjee, S, Barré, P, Canis, S, Warren, JD, Hwa, J, Menon, AK   +9 more
openaire   +4 more sources

Opsin Evolution in Flower-Visiting Beetles

Frontiers in Ecology and Evolution, 2021
Flowers have evolved signals that exploit the sensory systems of insect visitors. In the case of visual cues, color signals are thought to have been shaped in large part by the spectral sensitivity of key pollinators, such as hymenopterans.
Camilla R. Sharkey, Gareth S. Powell, Seth M. Bybee   +2 more
doaj   +1 more source

Ciliary Transport of Opsin [PDF]

, 2009
As part of the renewal of photoreceptor outer segment disk membranes, membrane proteins are transported along the region of the cilium, connecting the inner and outer segments. Genetics studies have indicated the role of motor proteins in this transport.
Deepti, Trivedi, David S, Williams
openaire   +2 more sources

Age-related deterioration of rod vision in mice [PDF]

, 2010
Even in healthy individuals, aging leads to deterioration in visual acuity, contrast sensitivity, visual field, and dark adaptation. Little is known about the neural mechanisms that drive the age-related changes of the retina and, more specifically ...
Crouch, Rosalie K, Fan, Jie, Kefalov, Vladimir J, Kolesnikov, Alexander V   +3 more
core   +2 more sources