Results 41 to 50 of about 40,625 (235)
Vision Research, 2006 Palmitylation is a widespread modification in G-protein-coupled receptors and often a dynamic process. In rhodopsins, palmitylation is static on C322/C323. Red/green (M/LWS) cone opsins have no cysteines at corresponding positions and no palmitylation.
Ablonczy, Zsolt +3 more
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Biochemical and Biophysical Research Communications, 2020 Optogenetics is a biological technique that combines the advantageous spatial-temporal resolution of optics and genetic cell targeting to control cellular activity with unprecedented precision. It has found vast applications both in neurosciences and therapy, particularly in view of its application to restore vision in blind patients.
Simon, Cardillia-Joe +4 more
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Red Light Optogenetics in Neuroscience
Frontiers in Cellular Neuroscience, 2022 Optogenetics, a field concentrating on controlling cellular functions by means of light-activated proteins, has shown tremendous potential in neuroscience.
Kimmo Lehtinen +3 more
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The two-photon reversible reaction of the bistable jumping spider rhodopsin-1 [PDF]
, 2019 Bistable opsins are photopigments expressed in both invertebrates and vertebrates. These light-sensitive G-protein-coupled receptors undergo a reversible reaction upon illumination.
Deupi, Xavier +7 more
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The Degeneration and Apoptosis Patterns of Cone Photoreceptors in rd11 Mice
Journal of Ophthalmology, 2017 The retinal degeneration 11 (rd11) mouse is a new animal model with rapid photoreceptor degeneration. The long-term efficacy of gene therapy has a direct relationship with the onset of photoreceptor degeneration or apoptosis, whereas the degeneration or ...
Hua Zhang +9 more
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Optogenetics: Tools for Controlling Brain Cells with Light [PDF]
Molecular Frontiers Journal, 2019 The brain is made out of an incredible diversity of cells called neurons, which have different shapes, are made of different molecules, and that change in different ways in diseases.
Edward S. Boyden
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Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish [PDF]
, 2016 Photoreceptors are highly specialized sensory neurons that possess a modified primary cilium called the outer segment. Photoreceptor outer segment formation and maintenance require highly active protein transport via a process known as intraflagellar ...
Akhtar +44 more
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Gene conversion and purifying selection shape nucleotide variation in gibbon L/M opsin genes
BMC Evolutionary Biology, 2011 Background Routine trichromatic color vision is a characteristic feature of catarrhines (humans, apes and Old World monkeys). This is enabled by L and M opsin genes arrayed on the X chromosome and an autosomal S opsin gene.
Siriaroonrat Boripat +9 more
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Retinal gene therapy with a large MYO7A cDNA using adeno-associated virus. [PDF]
, 2013 Usher 1 patients are born profoundly deaf and then develop retinal degeneration. Thus they are readily identified before the onset of retinal degeneration, making gene therapy a viable strategy to prevent their blindness.
Boye, S +8 more
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Palmitoylation stabilizes unliganded rod opsin [PDF]
Proceedings of the National Academy of Sciences, 2010 S-palmitoylation is a conserved feature in many G protein–coupled receptors (GPCRs) involved in a broad array of signaling processes. The prototypical GPCR, rhodopsin, is S-palmitoylated on two adjacent C-terminal Cys residues at its cytoplasmic surface.
Akiko, Maeda +6 more
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