Results 31 to 40 of about 38,225 (233)
Opsin Is a Phospholipid Flippase [PDF]
Current Biology, 2011 Polar lipids must flip-flop rapidly across biological membranes to sustain cellular life [1, 2], but flipping is energetically costly [3] and its intrinsic rate is low. To overcome this problem, cells have membrane proteins that function as lipid transporters (flippases) to accelerate flipping to a physiologically relevant rate.
Sakmar, TP +9 more
openaire +4 more sources
The Effect of Cone Opsin Mutations on Retinal Structure and the Integrity of the Photoreceptor Mosaic [PDF]
, 2012 Purpose. To evaluate retinal structure and photoreceptor mosaic integrity in subjects with OPN1LW and OPN1MW mutations. Methods. Eleven subjects were recruited, eight of whom have been previously described.
Banin, Eyal +19 more
core +2 more sources
Ciliary Transport of Opsin [PDF]
, 2009 As part of the renewal of photoreceptor outer segment disk membranes, membrane proteins are transported along the region of the cilium, connecting the inner and outer segments. Genetics studies have indicated the role of motor proteins in this transport.
Deepti, Trivedi, David S, Williams
openaire +2 more sources
High-Level Inducible Expression of Visual Pigments in Transfected Cells
BioTechniques, 1996 A method for high-level expression of a functionally active, recombinant human red cone opsin was developed by adding the coding sequence for the C-terminal epitope of bovine rhodopsin onto the C terminus of the cone opsin and cloning the resulting ...
Manija A. Kazmi +3 more
doaj +1 more source
Vision Research, 2006 Palmitylation is a widespread modification in G-protein-coupled receptors and often a dynamic process. In rhodopsins, palmitylation is static on C322/C323. Red/green (M/LWS) cone opsins have no cysteines at corresponding positions and no palmitylation.
Ablonczy, Zsolt +3 more
openaire +2 more sources
Biochemical and Biophysical Research Communications, 2020 Optogenetics is a biological technique that combines the advantageous spatial-temporal resolution of optics and genetic cell targeting to control cellular activity with unprecedented precision. It has found vast applications both in neurosciences and therapy, particularly in view of its application to restore vision in blind patients.
Simon, Cardillia-Joe +4 more
openaire +3 more sources
Gene-based Therapy in a Mouse Model of Blue Cone Monochromacy
Scientific Reports, 2017 Cones are responsible for daylight, central, high acuity and color vision. Three proteins found in human cones, i.e. long-wavelength (L)-, middle-wavelength (M)-, and short-wavelength sensitive (S)-opsins, are responsible for red, green and blue color ...
Yuxin Zhang +12 more
doaj +1 more source
BioengineeringOptogenetic modulation employs light-sensitive proteins known as opsins to regulate cellular activity. A unique therapeutic application of this technique involves modulating pain perception by selectively targeting neural pathways within the spinal cord.
Darryl Narcisse +3 more
doaj +1 more source
Molecular evolution and expression of opsin genes in Hydra vulgaris
BMC Genomics, 2019 Background The evolution of opsin genes is of great interest because it can provide insight into the evolution of light detection and vision. An interesting group in which to study opsins is Cnidaria because it is a basal phylum sister to Bilateria with ...
Aide Macias-Muñoz +2 more
doaj +1 more source
Opsin Evolution in Flower-Visiting Beetles
Frontiers in Ecology and Evolution, 2021 Flowers have evolved signals that exploit the sensory systems of insect visitors. In the case of visual cues, color signals are thought to have been shaped in large part by the spectral sensitivity of key pollinators, such as hymenopterans.
Camilla R. Sharkey +2 more
doaj +1 more source