[Research progress of optic atrophy 1-mediated mitochondrial dynamics in skeletal system diseases]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2023 To review the research progress of mitochondrial dynamics mediated by optic atrophy 1 (OPA1) in skeletal system diseases.The literatures about OPA1-mediated mitochondrial dynamics in recent years were reviewed, and the bioactive ingredients and drugs for the treatment of skeletal system diseases were summarized, which provided a new idea for the ...
Sun K, Wu Y, Zeng Y, Li M, Wu L, Shen B.
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Optic Atrophy 1-Dependent Mitochondrial Remodeling Controls Steroidogenesis in Trophoblasts [PDF]
Current Biology, 2012 During human pregnancy, placental trophoblasts differentiate and syncytialize into syncytiotrophoblasts that sustain progesterone production [1]. This process is accompanied by mitochondrial fragmentation and cristae remodeling [2], two facets of mitochondrial apoptosis, whose molecular mechanisms and functional consequences on steroidogenesis are ...
Wasilewski M +5 more
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Frontiers in Endocrinology, 2023 IntroductionDiabetic neuropathy and diabetic eye disease are well known complications of type 1 diabetes. We hypothesized that chronic hyperglycemia also damages the optic tract, which can be measured using routine magnetic resonance imaging. Our aim was to compare morphological differences in the optic tract between individuals with type 1 diabetes ...
Aleksi Tarkkonen +25 more
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Solving a 50 year mystery of a missing OPA1 mutation: more insights from the first family diagnosed with autosomal dominant optic atrophy [PDF]
, 2010 Background: Up to the 1950s, there was an ongoing debate about the diversity of hereditary optic neuropathies, in particular as to whether all inherited optic atrophies can be ascribed to Leber's hereditary optic neuropathy (LHON) or represent different ...
Alexander Christiane +35 more
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A clinical study of optic atrophy [PDF]
, 2022 Methods and materials:50 patients of optic atrophy attended to ophthalmology outpatient department from November 2019 to May 2021 were enquired about history of present illness, ingestion of toxic substances, Tobacco, alcohol, and examined for visual ...
Kola Vijaya Sekhar +3 more
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The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function. [PDF]
Nat Commun, 2018 AbstractIt is unclear how the mitochondrial fusion protein Optic atrophy 1 (OPA1), which inhibits cristae remodeling, protects from mitochondrial dysfunction. Here we identify the mitochondrial F1Fo-ATP synthase as the effector of OPA1 in mitochondrial protection.
Quintana-Cabrera R +12 more
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Nogo receptor 1 is expressed by nearly all retinal ganglion cells. [PDF]
PLoS ONE, 2018 A variety of conditions ranging from glaucoma to blunt force trauma lead to optic nerve atrophy. Identifying signaling pathways for stimulating axon growth in the optic nerve may lead to treatments for these pathologies.
Alexander M Solomon +3 more
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Optical Coherence Tomography Findings of Nonarteritic Ischemic Optic Neuropathy
Sakarya Tıp Dergisi, 2022 : Objective: To evaluate the optical coherence tomography (OCT) parameters in patients with nonartheritic ischemic optic neuropathy (NAION) and glaucomatous optic atrophy.
Sedat Özmen +4 more
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Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency [PDF]
Cell Death & Differentiation, 2012 Mitochondrial complex I dysfunction has long been associated with Parkinson's disease (PD). Recent evidence suggests that mitochondrial involvement in PD may extend beyond a sole respiratory deficit and also include perturbations in mitochondrial fusion/fission or ultrastructure.
Ramonet, D +7 more
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Optic atrophy 1 is an A‐kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis [PDF]
The EMBO Journal, 2011 Adrenergic stimulation of adipocytes yields a cAMP signal that activates protein kinase A (PKA). PKA phosphorylates perilipin, a protein localized on the surface of lipid droplets that serves as a gatekeeper to regulate access of lipases converting stored triglycerides to free fatty acids and glycerol in a phosphorylation-dependent manner.
Pidoux, Guillaume +7 more
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