Results 41 to 50 of about 29,975,358 (298)

The clinical profile of childhood optic neuritis [PDF]

Arquivos de Neuro-Psiquiatria, 2001
PURPOSE: To report the clinical features and outcome of a series of children with optic neuritis. METHODS: We reviewed the medical records of patients up to 16 years old with optic neuritis. Group 1 comprised children seen up to two weeks after the onset
Marco Aurélio Lana-Peixoto, Gustavo Cardoso de Andrade   +1 more
doaj   +1 more source

Gray matter atrophy rate as a marker of disease progression in AD [PDF]

, 2010
Global gray matter (GM) atrophy rates were quantified from magnetic resonance imaging (MRI) over 6- and 12-month intervals in 37 patients with Alzheimer's disease (AD) and 19 controls using: (1) nonlinear registration and integration of Jacobian values ...
Miller, David H., Nick C. Fox, Kelvin K. Leung, David H. Miller, Anderson, V.M., Anderson, Valerie M, Jonathan W. Bartlett, Leung, Kelvin K, Bartlett, J.W., Bartlett, Jonathan W., Leung, Kelvin K., Fox, Nick C, Schott, Jonathan M, Leung, K.K., Fox, Nick C., Schott, Jonathan M., Valerie M. Anderson, Fox, N.C., Anderson, Valerie M., Schott, J.M., Bartlett, Jonathan W, Jonathan M. Schott, Miller, David H, Miller, D. H., Schott, JM, Fox, NC, Leung, KK, Miller, DH, Anderson, Valerie, Bartlett, JW   +29 more
core   +1 more source

Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control [PDF]

Cell Reports, 2016
The mitochondrial contact site and cristae organizing system (MICOS) and Optic atrophy 1 (OPA1) control cristae shape, thus affecting mitochondrial function and apoptosis. Whether and how they physically and functionally interact is unclear. Here, we provide evidence that OPA1 is epistatic to MICOS in the regulation of cristae shape. Proteomic analysis
GLYTSOU, CHRISTINA, Calvo, Enrique, COGLIATI, SARA, MEHROTRA, ARPIT, ANASTASIA, IRENE, RIGONI, GIOVANNI, Raimondi, Andrea, Shintani, Norihito, Loureiro, Marta, Vazquez, Jesùs, PELLEGRINI, LUCA, Enriquez, Jose Antonio, SCORRANO, LUCA, SORIANO GARCIA - CUERVA, MARIA EUGENIA   +13 more
openaire   +3 more sources

Relationship Between Peripapillary Atrophy and Optic Disc Parameters in Eyes with Primary Open-Angle Glaucoma

, 2011
Pur po se: To evaluate the relationship between peripapillary atrophy and optic disc parameters measured by Heidelberg Retina Tomography (HRT) and visual field findings in eyes with primary open-angle glaucoma.
Gülizar Soyugelen, İzzet Can, Hale Çelik, Tamer Takmaz   +3 more
core   +1 more source

A case of a young patient with progressive vision loss: An atypical presentation of the rare Wolfram Syndrome in a Middle Eastern individual

American Journal of Ophthalmology Case Reports
Purpose: To describe an atypical presentation of a rare disease in a young middle eastern woman with a relatively adult-onset type 1 diabetes mellitus, bilateral optic atrophy and progressive decreased vision diagnosed as the Wolfram disease. Observation:
Meishar Meisel, Eran Berkowitz, Dana Irge, Beatrice Tiosano, Anat Kesler   +4 more
doaj   +1 more source

Establishing induced pluripotent stem cell lines from two dominant optic atrophy patients with distinct OPA1 mutations and clinical pathologies

Frontiers in Genetics, 2023
Dominant optic atrophy (DOA) is an inherited disease that leads to the loss of retinal ganglion cells (RGCs), the projection neurons that relay visual information from the retina to the brain through the optic nerve.
Katherine A. Pohl, Katherine A. Pohl, Xiangmei Zhang, Anh H. Pham, Jane W. Chan, Alfredo A. Sadun, Xian-Jie Yang, Xian-Jie Yang   +7 more
doaj   +1 more source

Pseudoexfoliative Glaucoma in a Patient with Toxic Optic Atrophy and Cupping

, 2011
A 57-year-old man, who had developed bilateral symmetric optic atrophy and cupping due to methanol intoxication nine years ago, noticed slowly progressive visual impairment in the left eye (OS). In ophthalmic examination, visual acuity was 20/60 in the
Dilaver Erşanlı, Ali Aydın, Ali Ayd›n, Akın Çakır, Ak›n Çak›r, Taner Kar, Ümit Aykan   +6 more
core   +1 more source

Generation and characterization of the hiPSC line CSSi023-A (16154) from a patient with ADOA caused by an OPA1 variant

Stem Cell Research
Autosomal Dominant Optic Atrophy plus syndrome (ADOA, OMIM #125250) is a mitochondrial optic neuropathy characterized by progressive degeneration of retinal ganglion cells (RGCs), leading to worsening visual impairment.
Angela Maria Giada Giovenale, Ilaria Ferrone, Silvia Tomaselli, Elisa Maria Turco, Martina Mazzoni, Barbara Torres, Paola Zanfardino, Edvige Vulcano, Daniela Ferrari, Devid Damiani, Filippo M. Santorelli, Alessandro De Luca, Maria Pennuto, Angelo Luigi Vescovi, Vittoria Petruzzella, Jessica Diana Rosati   +15 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Aetiological Profile of Optic Atrophy: A hospital based prospective study [PDF]

, 2020
Objectives: This study was to evaluateclinical presentations and aetiological profiles of patients with optic atrophy.Methods:The patients had undergone complete ophthalmological examination, i.e.
Agrawal, Shilpi, Singh, Rajiv Kumar, Kumar, Sunil, Kumar, Ashish, Kumar, Abhishek, Narnoli, Prasansha   +5 more
core   +1 more source