Results 51 to 60 of about 62,463 (295)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Overexpression of optic atrophy 1 protein increases cisplatin resistance via inactivation of caspase-dependent apoptosis in lung adenocarcinoma cells

, 2014
Optic atrophy 1 protein, a 112-kd guanosine triphosphatase, is involved in the mitochondrial inner membrane fusion and anticancer drug-mediated cytotoxicity, which implicate an association with disease progression of the cancer.
Fang, Hsin-Yuan, Lin, Tze-Yi, Chiou, Shiow-Her, Wang, Yu-Ting, Chen, Chih-Yi, Chiang, I-Ping, Chiang, I.P., Chow, Kuan-Chih, Chiou, S.H., Chang, Hui-Wen, Lan, K.J., Chow, K.C., Lan, Kuo-Jung, Chang, H.W., Fang, H.Y., Lin, T.Y., Wang, Y.T., Chen, C.Y.   +17 more
core   +1 more source

OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes [PDF]

Brain, 2008
Mutations in OPA1, a dynamin-related GTPase involved in mitochondrial fusion, cristae organization and control of apoptosis, have been linked to non-syndromic optic neuropathy transmitted as an autosomal-dominant trait (DOA). We here report on eight patients from six independent families showing that mutations in the OPA1 gene can also be responsible ...
Amati-Bonneau, Patrizia, Valentino, Maria Lucia, Reynier, Pascal, Gallardo, Maria Esther, Bornstein, Belén, Boissière, Anne, Campos, Yolanda, Rivera, Henry, de La Aleja, Jesús González, Carroccia, Rosanna, Iommarini, Luisa, Labauge, Pierre, Figarella-Branger, Dominique, Marcorelles, Pascale, Furby, Alain, Beauvais, Katell, Letournel, Franck, Liguori, Rocco, La Morgia, Chiara, Montagna, Pasquale, Liguori, Maria, Zanna, Claudia, Rugolo, Michela, Cossarizza, Andrea, Wissinger, Bernd, Verny, Christophe, Schwarzenbacher, Robert, Martín, Miguel Angel, Arenas, Joaquín, Ayuso, Carmen, Garesse, Rafael, Lenaers, Guy, Bonneau, Dominique, Carelli, Valerio   +33 more
openaire   +6 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic testing confirmed osteopetrosis with initial presentation of nystagmus

Taiwan Journal of Ophthalmology, 2023
Osteopetrosis (OS) is a rare heritable disorder characterized by osteoclast dysfunction and increased bone density on radiography. Optic nerve osseous compression is the most frequent ocular complication of OS, with nystagmus, strabismus, ptosis ...
Kai-Yen Chiu, Yu-Yang Lin, Yao-Lin Liu, Ni-Chung Lee, Tzu-Hsun Tsai   +4 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Morphological and functional characteristics of an eye in vibration disease patients

Oftalʹmologiâ, 2015
Aim: To analyze ocular fundus photos and visual field test findings in vibration disease patients depending on highfrequencyexposition.Methods: 62 vibration disease patients aged 40‑65 (55.69±0.7 years on average) were examined. The patients were divided
S. S. Malysheva, S. A. Petrov
doaj   +3 more sources

A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects

Disease Models & Mechanisms, 2019
Mitochondria continually move, fuse and divide, and these dynamics are essential for the proper function of the organelles. Indeed, the dynamic balance of fusion and fission of mitochondria determines their morphology and allows their immediate ...
Thomas Delerue, Déborah Tribouillard-Tanvier, Marlène Daloyau, Farnoosh Khosrobakhsh, Laurent Jean Emorine, Gaëlle Friocourt, Pascale Belenguer, Marc Blondel, Laetitia Arnauné-Pelloquin   +8 more
doaj   +1 more source

Fundus changes in high myopic Kashmiri population

Asian Journal of Medical Sciences, 2021
Background: High myopia (defined as myopia of -6D or more) is one of the main causes of visual impairment worldwide. High myopia is always accompanied by pathological structural changes such as axial elongation, posterior staphyloma, lacquer crack ...
Nazia Anjum , Numrah Muqsit , Junaid S Wani   +2 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source