NRF2 Deficiency Disrupts Mitochondrial Homeostasis via NDUFS7 in Trabecular Meshwork
ResearchThe trabecular meshwork (TM) plays a pivotal role in maintaining intraocular pressure (IOP) by regulating aqueous humor outflow. Nuclear factor erythroid 2-related factor 2 (NRF2) was identified as a key transcriptional controller of TM redox balance and
Xuejing Yan +6 more
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Retinal ganglion cell survival and axon regeneration in WldS transgenic rats after optic nerve crush and lens injury. [PDF]
, 2012 BACKGROUND: We have previously shown that the slow Wallerian degeneration mutation, whilst delaying axonal degeneration after optic nerve crush, does not protect retinal ganglion cell (RGC) bodies in adult rats.
Bull, Natalie D +4 more
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Mechanical activation of PIEZO1 drives AP-1–dependent PTGS2/PGE2 signaling and corneal inflammation
iScienceSummary: Abnormal mechanical stimulation, such as eye rubbing, is a critical risk factor for corneal diseases, yet the molecular mechanisms linking mechanical stimulation to inflammation remain unclear.
Zongzheng Zou +10 more
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Low-Field Magnetic Resonance Imaging Findings in 18 Dogs With Presumed Optic Neuritis
Frontiers in Veterinary Science, 2021 Canine optic neuritis has been attributed to a focal or disseminated form of granulomatous meningoencephalitis (GME) amongst other etiologies. Magnetic resonance imaging (MRI) has been proven to help differentiate the structures within the optic nerve ...
Laura Muñiz Moris +2 more
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The cell of origin dictates the temporal course of neurofibromatosis-1 (Nf1) low-grade glioma formation. [PDF]
, 2017 Low-grade gliomas are one of the most common brain tumors in children, where they frequently form within the optic pathway (optic pathway gliomas; OPGs).
Castillon, Guillaume A +9 more
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Molecular Therapy: Methods & Clinical DevelopmentAdeno-associated viral (AAV) vectors are being used increasingly in developing treatments for age-related ocular diseases, including those impacting retinal ganglion cells (RGCs), the output neurons of the eye.
Delaney CM. Henderson +1 more
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Multidimensional scaling of D15 caps: Color-vision defects among tobacco smokers? [PDF]
, 2004 Tobacco smoke contains a range of toxins including carbon monoxide and cyanide. With specialized cells and high metabolic demands, the optic nerve and retina are vulnerable to toxic exposure.
Bimler, David L, Kirkland, John
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The thickness of the retrobulbar portion of the optic nerve in Graves ophthalmopathy measured by ultrasound [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2009 Introduction. The clinical diagnostic of Graves ophthalmopathy is based on the association of ocular signs and the disease of the thyroid gland. The evolution of the disease involves the development of eye globe protrusion, extraocular muscle thickening ...
Stefanović Ivan +3 more
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Magnetic Resonance Imaging of Optic Nerve Traction During Adduction in Primary Open-Angle Glaucoma With Normal Intraocular Pressure. [PDF]
, 2017 PurposeWe used magnetic resonance imaging (MRI) to ascertain effects of optic nerve (ON) traction in adduction, a phenomenon proposed as neuropathic in primary open-angle glaucoma (POAG).MethodsSeventeen patients with POAG and maximal IOP ≤ 20 mm Hg, and
Bonelli, Laura +8 more
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Current Issues in Molecular BiologyGlaucoma is a leading cause of irreversible blindness, normally associated with dysfunction and degeneration of the trabecular meshwork (TM) as the primary cause.
Rong Du +5 more
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