Results 41 to 50 of about 179,043 (317)

Transcriptomic Differences Between Human Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells Reveal Specific Biomarker Profiles

Current Issues in Molecular Biology
Glaucoma is a leading cause of irreversible blindness, normally associated with dysfunction and degeneration of the trabecular meshwork (TM) as the primary cause.
Rong Du, Ajay Kumar, Enzhi Yang, Jingxue Zhang, Ningli Wang, Yiqin Du   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Accurate and reliable segmentation of the optic disc in digital fundus images [PDF]

, 2014
We describe a complete pipeline for the detection and accurate automatic segmentation of the optic disc in digital fundus images. This procedure provides separation of vascular information and accurate inpainting of vessel-removed images, symmetry-based ...
Giachetti, Andrea, Emanuele Trucco, Trucco, Emanuele; id_orcid, Lucia Ballerini, Ballerini, Lucia   +4 more
core   +1 more source

Correlation of optic nerve and optic nerve sheath diameter with intracranial pressure in pigs. [PDF]

, 2020
OBJECTIVE Several studies have shown an association between intracranial pressure and the diameter of the optic nerve sheath measured by transbulbar ultrasonography. To understand the pathophysiology of this phenomenon, we aimed to measure the changes
J. Beck (8399460), C. Fung (8399454), I. Zubak (8399445), S. M. Jakob (8399457), W. J. Z’Graggen (8399463), J Beck, Jakob, S. M., Zubak, I., A. Schuetz (8399448), R Mija, I Zubak, S M Jakob, Schuetz, A., Z'Graggen, W. J., C Fung, M Glas, A Schuetz, R. Mija (8399442), Fung, C., Beck, J., Glas, M., Andreas Bloch, Bloch, Andreas, Mija, R., Andreas Bloch (5489834), M. Glas (8399451), W J Z'Graggen   +26 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Lipid profiling dataset of the Wnt3a-induced optic nerve regeneration

Data in Brief, 2019
We present lipid profiling data from mouse retina and optic nerve after optic nerve crush and during Wnt3a-induced axonal regeneration at 7 and 15 days post-crush. This data is available at the Metabolomics Workbench, http://www.metabolomicsworkbench.org
Anna Trzeciecka, Tal Carmy, Abigail S. Hackam, Sanjoy K. Bhattacharya   +3 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Can automated imaging for optic disc and retinal nerve fiber layer analysis aid glaucoma detection? [PDF]

, 2016
Open Access funded by Department of Health UKPurpose: To compare the diagnostic performance of automated imaging for glaucoma. Design: Prospective, direct comparison study.
Banister, K, Burr, JM, McMeekin, P, Gray, J, Jonathan Cook (3435386), Rupert R. A. Bourne (3232398), Cook, Jonathan, Charles Boachie (725223), Garway-Heath, David, Joanne Gray (468122), Pete McMeekin (16670856), Hernández, Rodolfo, Ramsay, C, Gray, Joanne, Cook, J, McMeekin, Peter, Jennifer M. Burr (16657107), Ramsay, Craig, Burr, Jennifer, Katie Banister (8982902), Craig R. Ramsay (9096188), Hernández, R, David F. Garway-Heath (8770919), Boachie, Charles, Bourne, Rupert, Burr, Jennifer M., Azuara-Blanco, A, Banister, Katie, Garway-Heath, D, Azuara-Blanco, Augusto, Bourne, R, Augusto Azuara-Blanco (6328919), Rodolfo Hernández (16670859), Boachie, C   +33 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Macular ganglion cell complex layer thickness measured with spectral-domain OCT in a large population-based cohort study

BMC Ophthalmology
Purpose To establish the normal GCC thickness profile in the general population using SD-OCT in different macular sectors. Determining the systemic and ophthalmic factors associated with GCC thickness and further identifying the potential risk factors ...
Caixia Lin, Lixia Ma, Aiguo Lv, Hongyi Liu, Qing Pan, Kai Cao, Xu Jia, Sujie Fan, Jian Wu, Ningli Wang   +9 more
doaj   +1 more source