Results 61 to 70 of about 1,261,152 (360)

Macular ganglion cell complex layer thickness measured with spectral-domain OCT in a large population-based cohort study

BMC Ophthalmology
Purpose To establish the normal GCC thickness profile in the general population using SD-OCT in different macular sectors. Determining the systemic and ophthalmic factors associated with GCC thickness and further identifying the potential risk factors ...
Caixia Lin, Lixia Ma, Aiguo Lv, Hongyi Liu, Qing Pan, Kai Cao, Xu Jia, Sujie Fan, Jian Wu, Ningli Wang   +9 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The contribution of brain reorganisation to recovery in patients with optic neuritis [PDF]

, 2010
In this thesis, the mechanisms of damage and repair in clinically isolated optic neuritis (ON) were investigated in vivo, by combining magnetic resonance imaging (MRI), electrophysiology and optical coherence tomography (OCT).
Jenkins, T.M.
core  

Lipid profiling dataset of the Wnt3a-induced optic nerve regeneration

Data in Brief, 2019
We present lipid profiling data from mouse retina and optic nerve after optic nerve crush and during Wnt3a-induced axonal regeneration at 7 and 15 days post-crush. This data is available at the Metabolomics Workbench, http://www.metabolomicsworkbench.org
Anna Trzeciecka, Tal Carmy, Abigail S. Hackam, Sanjoy K. Bhattacharya   +3 more
doaj   +1 more source

NF1 mutation drives neuronal activity-dependent initiation of optic glioma

Nature, 2021
Neurons have recently emerged as essential cellular constituents of the tumour microenvironment, and their activity has been shown to increase the growth of a diverse number of solid tumours1.
Yuan Pan, Jared Hysinger, Tara Barron, Nicki Schindler, Olivia M Cobb, Xiaofan Guo, Belgin Yalçın, C. Anastasaki, Sara B. Mulinyawe, Anitha Ponnuswami, S. Scheaffer, Yu Ma, Kun-Che Chang, Xin Xia, J. Toonen, J. Lennon, Erin M. Gibson, J. Huguenard, L. Liau, J. Goldberg, Michelle Monje, D. Gutmann   +21 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Molecular mechanisms separating two axonal pathways during embryonic development of the avian optic tectum [PDF]

, 1991
During embryonic development of the avian optic tectum, retinal and tectobulbar axons form an orthogonal array of nerve processes. Growing axons of both tracts are transiently very closely apposed to each other. Despite this spatial proximity, axons from
Kröger, Stephan, Walter, Jochen, Kröger, S. ; https://orcid.org/, Walter, J.   +3 more
core   +1 more source

Topical administration of a Rock/Net inhibitor promotes retinal ganglion cell survival and axon regeneration after optic nerve injury

Experimental Eye Research, 2016
Intraocular pressure (IOP)‐lowering ophthalmic solutions that inhibit Rho‐associated protein kinases (Rock) and norepinephrine transporters (Net) are currently under clinical evaluation.
P. Shaw, Alan Sang, Yan Wang, Daisy Ho, Christopher Douglas, Lara Dia, J. Goldberg   +6 more
semanticscholar   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

ATF3 upregulation in glia during Wallerian degeneration: differential expression in peripheral nerves and CNS white matter [PDF]

, 2004
Background: Many changes in gene expression occur in distal stumps of injured nerves but the transcriptional control of these events is poorly understood.
Coffin, RS, Hossain-Ibrahim Kismet, Mason, MRJ, Lieberman AR, Lieberman, AR, Mason Matthew RJ, Hossain-Ibrahim, K, David Hunt, Winterbottom, J, Anderson, PN, Hunt David, AR Lieberman, Kismet Hossain-Ibrahim, Anderson PN, Coffin Robert S, Hunt, D, PN Anderson, Matthew RJ Mason, Robert S Coffin, Winterbottom Julia, Julia Winterbottom   +20 more
core   +1 more source