Results 81 to 90 of about 1,261,152 (360)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Development of a novel SupraChoroidal-to-Optic-NervE (SCONE) drug delivery system

Drug Delivery
Purpose Targeted drug delivery to the optic nerve head may be useful in the preclinical study and later clinical management of optic neuropathies, however, there are no FDA-approved drug delivery systems to achieve this.
Bryce Chiang, Kathleen Heng, Kyeongwoo Jang, Roopa Dalal, Yaping Joyce Liao, David Myung, Jeffrey L Goldberg   +6 more
doaj   +1 more source

Echographic Optic Nerve Evaluation: A Novel Diagnostic Modality in Glaucoma [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Primary Open-Angle Glaucoma (POAG) is considered a leading cause of blindness among all others. Different technologies such as Scanning Laser Polarimetry (SLP) and Optical Coherence Tomography (OCT) closely correlate in measuring structural
Avik Dey Sarkar, Sanchari Sarkar
doaj   +1 more source

Magnetic resonance imaging of optic nerve

Indian Journal of Radiology and Imaging, 2015
Optic nerves are the second pair of cranial nerves and are unique as they represent an extension of the central nervous system. Apart from clinical and ophthalmoscopic evaluation, imaging, especially magnetic resonance imaging (MRI), plays an important ...
F. Gala
semanticscholar   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Histopathology of optic nerve pit-associated maculopathy [PDF]

, 2012
John B Christoforidis, William Terrell, Frederick H DavidorfCollege of Medicine, The Ohio State University, Columbus, OH, USAPurpose: To describe the histopathologic findings of an eye bank specimen containing an optic nerve pit with associated serous ...
Terrell W, Christoforidis JB, Davidorf FH   +2 more
core  

Comparison of cross sectional optical coherence tomography images of elevated optic nerve heads across acquisition devices and scan protocols

Eye and Vision, 2018
Background Optic nerve head measurements extracted from optical coherence tomography (OCT) show promise for monitoring clinical conditions with elevated optic nerve heads.
Megh D. Patel, Fareshta Khushzad, Heather E. Moss   +2 more
doaj   +1 more source

Optic Nerve Regeneration [PDF]

Archives of Ophthalmology, 2010
Retinal ganglion cells are usually not able to regenerate their axons after optic nerve injury or degenerative disorders, resulting in lifelong visual loss. This situation can be partially reversed by activating the intrinsic growth state of retinal ganglion cells, maintaining their viability, and counteracting inhibitory signals in the extracellular ...
Larry I, Benowitz, Yuqin, Yin
openaire   +2 more sources

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Development of a novel model of optic neuritis to assess neuroprotective and repair strategies in multiple sclerosis [PDF]

, 2012
PhDMultiple sclerosis (MS) is a putative autoimmune disease of the central nervous system (CNS), which often affects the optic nerve pathway. Optic neuritis (ON) is a clinical feature of MS that can cause loss of vision due to conduction block and ...
Lidster, Katie
core