Results 121 to 130 of about 553,104 (200)

Plication of the Optic Nerve: A Mechanism for Rapid Vision Loss in Optic Nerve Glioma

, 2017
Optic nerve glioma (ONG) is the most common optic nerve tumor of childhood presenting with gradual proptosis, strabismus and visual loss. Rarely, such patients may develop acute loss of vision with worsening proptosis which has been associated with new ...
Nailyn Rasool; Ashley Campbell; Michael Kazim
core  

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

Histopathology of optic nerve pit-associated maculopathy

, 2012
John B Christoforidis, William Terrell, Frederick H DavidorfCollege of Medicine, The Ohio State University, Columbus, OH, USAPurpose: To describe the histopathologic findings of an eye bank specimen containing an optic nerve pit with associated serous ...
Terrell W, Christoforidis JB, Davidorf FH   +2 more
core  

Unveiling Functional‐Metabolic Synergy in the Healthy Brain: Multivariate Integration of Dynamic [18F]FDG‐PET and Resting‐State fMRI

Human Brain Mapping, Volume 47, Issue 14, October 1, 2026.
ABSTRACT Despite accounting for only 2% of body weight, the human brain requires significant amounts of glucose, even at rest, underscoring the importance of functional‐metabolic relationships. Previous studies revealed moderate associations between resting‐state fMRI functional connectivity (FC) and local metabolism via [18F]FDG‐PET, yet much remains ...
Claudia Tarricone, Giulia Vallini, Giorgia Baron, Massimiliano Facca, Erica Silvestri, Tommaso Volpi, Andrei G. Vlassenko, Manu S. Goyal, Alessandra Bertoldo   +8 more
wiley   +1 more source

Cancer Risk in Marfan Syndrome: A Swedish Population‐Based Cohort Study

International Journal of Cancer, Volume 159, Issue 7, Page 1707-1714, 1 October 2026.
The cancer risk in Marfan syndrome, an autosomal dominant connective tissue disorder, largely remains to be explored. In this population‐based matched cohort study of 1544 Swedish patients, the overall cancer risk in adults with Marfan syndrome showed no significant increase, except for the risk of endocrine tumours with a nearly threefold increase ...
Ida Nordgren, Anna Skarin Nordenvall, Alexandra Wachtmeister, Fulya Taylan, Yunxia Lu, Christina Norrby, Anna Lindstrand, Giedre Grigelioniene, Giorgio Tettamanti   +8 more
wiley   +1 more source

Harnessing Natural Killer Cells: From Neuroimmunology to Novel Therapies for Central Nervous System Diseases

MedComm, Volume 7, Issue 10, October 2026.
This review delineates the multifaceted roles of natural killer (NK) cells in the central nervous system, spanning direct cytolysis, immunoregulation, and crosstalk with the brain microenvironment. We evaluate the translational potential and challenges of NK cell immunotherapies for a spectrum of neurological conditions.
Kaihang Deng, Wai Po Chong
wiley   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

11‐year‐old girl presenting with blurred vision and progressive right arm weakness

Brain Pathology, Volume 36, Issue 6, November 2026.
Trung Toan Tran, Thi My Hanh Luong, Bérengère Dadone‐Montaudié, Hong Nhung Ta, Thai Hoc Nguyen, Fanny Burel‐Vandenbos, Gia Du Pham   +6 more
wiley   +1 more source

Digital health interventions for psychological and cognitive care in cancer patients and caregivers: A RE‐AIM‐based systematic review

Applied Psychology: Health and Well-Being, Volume 18, Issue 5, October 2026.
Abstract Beyond physical challenges, cancer can cause psychological and cognitive challenges for patients, caregivers, and family members. Digital health interventions show promise in addressing these issues. However, evidence on their applicability in daily cancer care is limited. The objective of this systematic review is to evaluate the internal and
Melissa Heifez, Laura Ciria‐Suarez, Sara Martín‐Parra, Ilaria Durosini, Dario Monzani, Veronica Coppini, Maria Vittoria Ferrari, Mareike Rutenkröger, Marie Lange, Nikolina Dodlek, Lotte van der Weijst, Andreas Charalambous, Marta Perez‐Campdepadrós, Derek Clougher, Miguel Angel Orrego, Gabriella Pravettoni, Cristian Ochoa‐Arnedo   +16 more
wiley   +1 more source