Results 61 to 70 of about 3,087 (193)

The rs10191329 Risk Allele Is Associated With Pronounced Retinal Layer Atrophy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, Volume 12, Issue 11, Page 2226-2234, November 2025.
ABSTRACT Objective To investigate whether the rs10191329 risk allele in the DYSF–ZNF638 locus, which is implicated in central nervous system resilience rather than immune‐mediated pathology, is associated with retinal layer thinning, a biomarker of neuroaxonal damage in relapsing multiple sclerosis (RMS). Methods From a prospective observational study,
Gabriel Bsteh, Ruchi Tanavade, Nik Krajnc, Fabian Föttinger, Theresa König, Martin Krenn, Lukas Haider, Barbara Kornek, Fritz Leutmezer, Kerstin U. Ludwig, Stefan Macher, Tobias Monschein, Markus Ponleitner, Paulus Rommer, Christiane Schmied, Karin Zebenholzer, Tobias Zrzavy, Gudrun Zulehner, Franziska Di Pauli, Axel Schmidt, Harald Hegen, Berthold Pemp, Thomas Berger   +22 more
wiley   +1 more source

Stimuli‐responsive systems: A focus on controlled drug delivery for posterior segment ocular disease

Responsive Materials, Volume 3, Issue 4, November 2025.
This review highlights recent advances in stimuli‐responsive drug delivery for posterior segment diseases, focusing on mechanisms and potential. It also explores mechanically interlocked molecules and bioorthogonal reactions as novel approaches. Challenges and future perspectives are discussed, aiming to bridge the gap between research and clinical ...
Chengzhi Zhang, Jiayi Hou, Yameng Zhao, Yiwen Wang, Kexin Wang, Siyu Li, Yange Wang, Jiehao Zhang, Shenao Ding, Chenxu Zhang, Zongming Song, Ye Tao   +11 more
wiley   +1 more source

Retinal biomarkers in cognitive impairment and dementia: Structural, functional, and molecular insights

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract Cognitive impairment and dementia, including Alzheimer's disease (AD), pose a global health crisis, necessitating non‐invasive biomarkers for early detection. This review highlights the retina, an accessible extension of the central nervous system (CNS), as a window to cerebral pathology through structural, functional, and molecular ...
Yan Min, Hongyu Zhou, Zixiao Li, Yongjun Wang   +3 more
wiley   +1 more source

Coexistence of Optic Nerve Head Drusen and Combined Hamartoma of the Retina and Retinal Pigment Epithelium in a Taiwanese Male

Kaohsiung Journal of Medical Sciences, 2009
We report the case of a 38-year-old male patient with a 1-year history of progressively blurred vision in his left eye. He visited our clinic and underwent a series of ophthalmologic examinations including computed tomography, fluorescein angiography and
Yo-Chen Chang, Rong-Kung Tsai
doaj   +1 more source

Semaglutide and non‐arteritic anterior ischaemic optic neuropathy: Review and interpretation of reported association

Acta Ophthalmologica, Volume 103, Issue 6, Page 615-621, September 2025.
Abstract This review covers a seminal study of the relation between exposure to the glucagon‐like peptide 1 (GLP‐1) agonist semaglutide and incident non‐arteritic anterior ischaemic optic neuropathy (NAION) in a neuro‐ophthalmology clinic setting, subsequent studies in unselected populations, a meta‐analysis of clinical trials and pathophysiology ...
Abdullah Amini, Steffen Hamann, Michael Larsen   +2 more
wiley   +1 more source

Optic Disc Drusen Prevalence in Patients with Retinitis Pigmentosa

, 2023
Optic disc drusen (ODD) are acellular deposits in the optic nerve head prevalent in 2% of the general population. The prevalence is increased in patients with the rare inherited disease retinitis pigmentosa (RP) but in previous studies great variation (3.
Alvilda Steensberg; Lasse Malmqvist; Line Kessel; Mette Bertelsen; Karen Grønskov; Steffen Hamann
core  

Diagnostic Ability of Transverse Axial Images Obtained by Optical Coherence Tomography for Detecting Anterior Displacement of Peripapillary Tissues in Papilledema

Clinical &Experimental Ophthalmology, Volume 53, Issue 7, Page 825-833, September/October 2025.
ABSTRACT Background To evaluate the diagnostic ability of optical coherence tomography (OCT) images to detect posterior pole deformation and anterior displacement of the optic disc (ADOD) in papilledema before and after intracranial pressure reduction with medical treatment.
Gabriel Castilho S. Barbosa, Rodrigo S. Pegado, Fernanda N. Susanna, Kenzo Hokazono, Mário Luiz R. Monteiro, Leonardo Provetti Cunha   +5 more
wiley   +1 more source

Frequency of retinal findings after 8 years in the Bifocal Lenses in Nearsighted Kids (BLINK) Study

Ophthalmic and Physiological Optics, Volume 45, Issue 6, Page 1475-1484, September 2025.
Abstract Purpose The purpose of the study is to report the frequency of retinal findings in myopic children and determine the association with the amount of myopia or axial length. Design The BLINK study was a myopia control, multi‐centre randomised clinical trial following myopic children with multifocal soft contact lenses. Participants Children aged
Krystal L. Schulle, Loraine T. Sinnott, Danielle J. Orr, Rachel L. Fenton, Lisa A. Jones‐Jordan, David A. Berntsen, Donald O. Mutti, Jeffrey J. Walline, Bifocal Lenses in Nearsighted Kids (BLINK) Study Group, Kimberly J. Shaw, Jenny Huang Jones, Bradley E. Dougherty, Mora E. Boatman, Loraine T. Sinnott, Matthew L. Robich, G. Lynn Mitchell, Pamela S. Wessel, Laura Cardenas, Krystal L. Schulle, Dashaini V. Retnasothie, Amber Gaume Giannoni, Anita Tićak, Maria K. Walker, Moriah A. Chandler, Mylan T. Nguyen, Lea A. Hair, Augustine N. Nti, Justina R. Assaad, Erin S. Tomiyama, Jill A. Myers, Alex D. Nixon, Katherine M. Bickle, Gilbert E. Pierce, Kathleen S. Reuter, Dustin J. Gardner, Matthew Kowalski, Ann Morrison, Danielle J. Orr, Elizabeth Day, Rachel L. Fenton, Janet T. Holbrook, Jane Gwiazda, Timothy B. Edrington, John Mark Jackson, Charlotte E. Joslin   +44 more
wiley   +1 more source

Trends and Clinical Characteristics of Pediatric Patients Presenting to an Ophthalmology Emergency Department with an Initial Diagnosis of Optic Nerve Head Elevation

Clinical Ophthalmology, 2022
Kara M Cavuoto, Zahra Markatia, Annika Patel, Carla J Osigian Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USACorrespondence: Kara M Cavuoto, Department of Ophthalmology, Bascom ...
Cavuoto KM, Markatia Z, Patel A, Osigian CJ   +3 more
doaj  

In-vivo high resolution imaging of optic nerve head drusen using spectral-domain Optical Coherence Tomography

BMC Medical Imaging, 2010
Background Optic nerve head drusen (ONHD) are white calcareous deposits, seen either superficially on the optic nerve head or buried within it. Diagnosis of ONHD is made by one or more ways: clinical exam, autofluorescence, ultrasound of the optic nerve,
Brar Vikram S, Grover Sandeep, Storm Laura, Murthy Ravi K, Chalam Kakarla V   +4 more
doaj   +1 more source